Estimating the effect of endogenous dopamine on baseline [11C]‐(+)‐PHNO binding in the human brain

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We estimate the sensitivity of the agonist radioligand [11C]‐(+)‐PHNO for quantifying endogenous dopamine levels at D2/3 receptors in the living human brain. As proof of concept, we use [11C]‐(+)‐PHNO to estimate the in vivo dissociation constant (Kd) for dopamine at D2/3. These results are in accordance with in vitro findings.

Source: Synapse - June 25, 2016 Category: Neurology Authors: Fernando Caravaggio, Lawrence S. Kegeles, Alan A. Wilson, Gary Remington, Carol Borlido, David C. Mamo, Ariel Graff‐Guerrero Tags: Research Article Source Type: research