Investigation of the role of alpha ‐2 adrenergic receptors on prepulse inhibition of acoustic startle reflex in rats

Conclusion: Because idazoxan and clonidine also act through imidazoline receptors, our results suggest that alpha‐2 and/or imidazoline receptors are associated with PPI of acoustic startle reflex in rats. Stimulation of these receptors may cause sensorimotor gating disturbances. This article is protected by copyright. All rights reserved. GRAPHICAL ABSTRACT Clonidine, an alpha‐2 agonist, produced significant disruptions in PPI of rats. This effect was reversed by specific antagonist idazoxan (figure). Thus, alpha‐2 adrenergic receptor stimulation may cause sensorimotor gating disturbances.
Source: Synapse - Category: Neurology Authors: Tags: Research Article Source Type: research