Prediction of striatal D2 receptor binding by DRD2/ANKK1 TaqIA allele status

This article is protected by copyright. All rights reserved. We investigated the difference in striatal dopamine D2 receptor binding, as measured by PET with (N‐[11C]methyl)benperidol ([11C]NMB), between A1 allele carriers (A1+) and individuals homozygous for the A2 allele (A1‐) of the DRD2/ANKK1 TaqIA single nucleotide polymorphism. In Study 1, A1+ had 5‐12% less striatal [11C]NMB binding than A1‐.

http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1002%2Fsyn.21916

Source: Synapse - May 31, 2016 Category: Neurology Authors: Sarah A. Eisenstein, Ryan Bogdan, Latisha Love‐Gregory, Nadia S. Corral‐Frías, Jonathan M. Koller, Kevin J. Black, Stephen M. Moerlein, Joel S. Perlmutter, Deanna M. Barch, Tamara Hershey Tags: Research Article Source Type: research