A Large Healthcare-Associated Outbreak of Hepatitis C Virus Genotype 1a in a Clinic in Korea
Globally, hepatitis C virus (HCV) affects more than 180 million people, with 3 –4 million new infections per year. HCV infection, one of the leading causes of chronic liver disease, is associated with end-stage cirrhosis and hepatocellular carcinoma [1]. In Korea, the prevalence of HCV is reportedly 0.41% to 2.1%, and it differs depending on target group, age, and region [1, 2]. HCV, a member of the Flaviviridae family, is an enveloped, positive sense single-stranded RNA virus; its genome size is approximately 9.4 kb. (Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - July 22, 2018 Category: Virology Authors: Yoon-Seok Chung, Ju-yeon Choi, Myung Guk Han, Kye Ryeong Park, Su-Jin Park, Hyerim Lee, Youngmee Jee, Chun Kang Source Type: research
Diagnostic utility of hepatitis E virus antigen-specific ELISA versus PCR testing in a cohort of post liver transplant patients in a large university hospital
Hepatitis E virus (HEV) was first isolated by Mikhail Balayan in 1983 and is a positive sense single-stranded non-enveloped RNA virus of the Hepeviridae family [1]. It is recognised as a leading cause of acute infectious hepatitis worldwide affecting around 20 million people a year and responsible for over 50,000 deaths [2]. It is currently the most common cause of enteric acute hepatitis in the UK [3]. (Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - July 20, 2018 Category: Virology Authors: G. Soothill, S. Hessey, M. Erotocritou, P. Griffiths, S. Ijaz, D. Thorburn, M. Ankcorn, D. Irish Source Type: research
Human papillomavirus (HPV) shedding in breast milk from African women living with HIV
Little is known about human papillomavirus (HPV) shedding in breast milk. Only few studies have reported this shedding, with conflicting conclusions. HPV was not detected in breast milk by Mammas et al. [1], whereas cutaneous HPV types were identified by Cazzaniga et al. [2] in ductal lavages or breast milk, with a strong reduction of HPV positivity after removal of the superficial layers of the nipple epidermis, suggesting that most of the cutaneous HPV DNA detected in lavage fluids resulted from a contamination by epidermal HPVs. (Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - July 18, 2018 Category: Virology Authors: Sophie Diaz, Nathalie Boulle, Jean-Pierre Mol ès, Marianne Peries, David Rutagwera, Chipepo Kankasa, James K. Tumwine, Philippe Van de Perre, Michel Segondy Tags: Short communication Source Type: research
Editorial Board
(Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - July 17, 2018 Category: Virology Source Type: research
ESCV Membership
(Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - July 17, 2018 Category: Virology Source Type: research
PASCV Membership
(Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - July 17, 2018 Category: Virology Source Type: research
Re: Lack of Zika virus antibody response in confirmed patients in non-endemic countries
With interest we read the paper 'Lack of Zika virus antibody response in confirmed patients in non-endemic countries ’ [1]. Lustig et al. present results of the largest series to date of ZIKV-specific antibody detection in sera by an NS1-based ELISA (Euroimmun, Lübeck, Germany) for 401 returning travelers with RT-PCR confirmed Zika virus (ZIKV) infection. (Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - July 16, 2018 Category: Virology Authors: Ralph Huits, Dorien Van Den Bossche, Emmanuel Bottieau, Marjan Van Esbroeck Tags: Letter to the Editor Source Type: research
Diagnostic accuracy of digital RNA quantification versus real-time PCR for the detection of respiratory syncytial virus in nasopharyngeal aspirates from children with acute respiratory infection
Respiratory syncytial virus (RSV) is one of the most common etiological agents of acute respiratory infections (ARI) among children such as bronchiolitis and pneumonia [1,2]. RSV can be divided into two subgroups (A and B) that commonly produce annual epidemics characterized by the circulation of several genotypic strains [3]. The seasonality of RSV-A and RSV-B can be markedly different [4]. Virus-specific molecular assays such as real-time polymerase chain reaction (RT-PCR) are now considered the gold standard in the diagnosis of viral respiratory tract infections. (Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - July 15, 2018 Category: Virology Authors: Maiara L. Bouzas, Juliana R. Oliveira, Artur Queiroz, Kiyoshi F. Fukutani, Aldina Barral, Annabel Rector, Elke Wollants, Els Keyaerts, Winke Van der Gucht, Marc Van Ranst, Kurt Beuselinck, Camila I. de Oliveira, Johan Van Weyenbergh, Cristiana M. Nascimen Source Type: research
Evaluation of the virtues and pitfalls in an HIV screening algorithm based on two fourth generation assays – a step towards an improved national algorithm
HIV screening is of great importance to identify all HIV infected persons to facilitate their linkage to care [1,2]. Early detection of HIV infection and prompt initiation of antiretroviral therapy improves life expectancy and life quality and prevents onward viral transmission. [3 –12]. Screening and detection of 90% of all HIV infected people by year 2020 was recently declared as a major goal by UNAIDS [13]. (Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - July 9, 2018 Category: Virology Authors: Boaz Avidor, Daniel Chemtob, Dan Turner, Irene Zeldis, Shirley Girshengorn, Natalia Matus, Svetlana Achsanov, Simona Gielman, Inbal Schweizer, Lilya Baskin, Licita Schreiber, Zipi Kra-oz Source Type: research
Combination random isothermal amplification and nanopore sequencing for rapid identification of the causative agent of an outbreak
Identifying the causative agent implicated in an outbreak is crucial for selecting the suitable treatment and/or control measures [1]. For example, around 25 pathogens can cause influenza like symptoms in the acute phase [2] and up to 20 pathogens have to be considered for diarrhoea [3]. (Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - July 6, 2018 Category: Virology Authors: S ören Hansen, Oumar Faye, Sabri S. Sanabani, Martin Faye, Susanne Böhlken-Fascher, Ousmane Faye, Amadou A. Sall, Michaël Bekaert, Manfred Weidmann, Claus-Peter Czerny, Ahmed Abd El Wahed Source Type: research
Comparison of the Biofire FilmArray Respiratory Panel, Seegene AnyplexII RV16, and Argene for the detection of respiratory viruses
Respiratory infections are one of the most common reasons for hospital admission [1,2]. Identification of the causative agent is often omitted or limited to a few pathogens easily detectable by direct antigen tests [2]. However, the reliable diagnosis of respiratory infection is important for therapy [3], implementation of isolation measures [4], and better use of antimicrobial therapy [5]. Epidemiological data from the laboratory can be used for prescribing prophylactic treatments for at risk patients [6,7], or for alerting to new or seasonal spread of pathogens [2]. (Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - July 6, 2018 Category: Virology Authors: Maurice Chan, Seok Hwee Koo, Boran Jiang, Pei Qi Lim, Thean Yen Tan Source Type: research
Evaluation of a rapid point-of-care HIV screening program in an emergency department setting in Detroit, Michigan
In October 2013, Detroit ’s only sexually transmitted disease (STD) clinic, at the Herman Kiefer Health Complex, was closed, which decreased access to HIV testing for many persons at substantial risk for acquiring infection [1]. Emergency departments (EDs), like STD clinics, often serve as a safety net for underinsured in dividuals but integrating additional services can be difficult given time and space constraints. This journal previously published an evaluation of a rapid point-of-care (POC) HIV antigen/antibody (Ag/Ab) test using stored specimens [2] and here we present an evaluation of this test to identify undi agn...
Source: Journal of Clinical Virology - June 27, 2018 Category: Virology Authors: Weiming Zhu, Kimberly Mumby, Doreen Dankerlui, Jake Manteuffel, Cal Ham, Ya-lin A. Huang, Philip J. Peters, Yetunde F. Fakile, Norman Markowitz, Karen W. Hoover Source Type: research
Unrecognized prolonged viral replication in the pathogenesis of human RSV Infection
RSV is a major cause of lung disease in adults and children accounting for as many as one million pediatric deaths annually.[1] RSV is a leading cause of infant hospitalizations in the US accounting for nearly 50% of all pneumonia and up to 90% of reported cases of bronchiolitis in infancy with mortality rates approximately ten times higher than those for influenza in infants. [2,3,4] RSV mortality rates in adults approach those for influenza and the disease causes significant morbidity and mortality in immunocompromised and frail, elderly adult patient populations. (Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - June 26, 2018 Category: Virology Authors: Bindiya Bagga, L Harrison, P Roddam, JP DeVincenzo Source Type: research
Evaluating the Aptima HIV-1 Quant Dx, HCV Quant Dx and HBV Quant assays against the Abbott HIV-1, HCV and HBV RealTime assays
Viral load measurements with quantitative nucleic acid amplification tests (NAATs) are part of the clinical management of patients infected with HIV, HCV or HBV [1 –6]. Automated platforms that perform a wide array of assays, such as the Hologic Panther platform are increasingly becoming a practical solution for busy diagnostic Virology laboratories. Therefore it is important to perform verifications of multiple assays simultaneously before introducing new p latforms into the laboratory. However, platforms are not all equivalent in terms of turnaround time, random access capability and operator hands on time [7–8]. (So...
Source: Journal of Clinical Virology - June 25, 2018 Category: Virology Authors: Shoshanna May, Ewelina Adamska, J.W. Tang Tags: Short communication Source Type: research
A fully automated system using transcription-mediated amplification for the molecular diagnosis of hepatitis E virus in human blood and faeces
The past 10 years have seen the recognition of the hepatitis E virus (HEV) as a pathogen of global significance. HEV strains that infect humans belong to 4 major genotypes and are subdivided in several subtypes [1]. Genotypes 1 and 2 infect only humans in developing countries [2]. Genotypes 3 and 4 are transmitted zoonotically in industrialized countries [2]; HEV genotype 7, which infects camels can be transmitted to humans [3]. Symptoms of HEV infection can vary from asymptomatic to fulminant hepatitis. (Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - June 22, 2018 Category: Virology Authors: Florence Abravanel, S ébastien Lhomme, Sabine Chapuy-Regaud, Jean-Michel Mansuy, Jérôme Boineau, Karine Sauné, Jacques Izopet Source Type: research
