Dolutegravir (DTG)-containing regimens after receiving raltegravir (RAL) or elvitegravir (EVG): durability and virological response in a large Italian HIV drug resistance network (ARCA)
Dolutegravir (DTG) is a next generation HIV-1 and HIV-2 integrase inhibitor (INI) with potent activity against wild-type and first-generation INI-resistant virus and a high genetic barrier to the development of resistance [1]. The activity of DTG has been demonstrated in several clinical trials, both in drug-naive [2 –4] and experienced subjects [6–8], as well as in subjects who were drug-experienced but INI-naive [9]. (Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - June 21, 2018 Category: Virology Authors: S. Rusconi, F. Adorni, P. Tau, V. Borghi, M. Pecorari, R. Maserati, D. Francisci, L. Monno, G. Punzi, P. Meraviglia, S. Paolucci, A. Di Biagio, B. Bruzzone, A. Mancon, V. Micheli, M. Zazzi, on behalf of ARCA (Antiviral Response Cohort Analysis) Source Type: research
Professor Peter J. F. Snijders, PhD (5 August 1961 –27 May 2018 †)
It is with great sadness I must inform you that Professor Peter J. F. Snijders, PhD has passed away after a long struggle against oesophageal cancer. (Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - June 15, 2018 Category: Virology Authors: Mario Poljak Tags: Obituary Source Type: research
Inconsistent detection of an evolving HIV-1 infection by a popular high-throughput screening assay
A 27 year old female patient presented with a 2-week history of sore throat, tender cervical adenopathy, fever and vomiting, following unprotected sex with a new partner. She had also recently developed painful mouth ulcers and a rash. Investigations revealed generalised lymphadenopathy, splenomegaly, an atypical lymphocytosis, transient hepatitis (alanine transferase 86 IU/ml) and thrombocytopaenia (119 × 109/L). Her clinical presentation was consistent with a differential diagnosis of glandular fever, as well as possible HIV seroconversion illness, and an acute viral hepatitis. (Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - June 12, 2018 Category: Virology Authors: James B. Veater, Judi Gardener, Benedict Rogers, Iain Stephenson, Julian W. Tang Tags: Letter to the editor Source Type: research
Change in viral bronchiolitis management in hospitals in the UK after the publication of NICE guideline
Viral bronchiolitis results in up to 25,000 hospital admissions per year in England with a 15-fold variation in hospital admission rates between different NHS Trusts across England [1]. Individual differences in hospital management have been suggested as a contributory factor to this variation [2]. The National Institute for Health and Care Excellence (NICE) published the first national (English) bronchiolitis guideline in June 2015 [3] to try to reduce this variation in management. We have previously shown that many Trusts were not compliant with the NICE guideline prior to its ’ publication [4], despite similar guidanc...
Source: Journal of Clinical Virology - June 12, 2018 Category: Virology Authors: Rachael Barr, Elliott J. Carande, Andrew J. Pollard, Simon B. Drysdale Source Type: research
T-Track-CMV and QuantiFERON-CMV assays for prediction of protection from CMV reactivation in kidney transplant recipients
Primary or reactivation of latent human cytomegalovirus (CMV) infection is a common complication within the first six months after solid-organ transplantation (SOT). SOT patients with a serological mismatch between the donor and the recipient (CMV donor (D) IgG +/recipient (R) -) are at high-risk for the development of CMV infection. In addition, CMV seropositive patients (D+/R + and D-/R+) are considered intermediate risk, whilst the CMV D-/R- constellation is considered low risk. [1,2] (Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - June 11, 2018 Category: Virology Authors: Smaranda Gliga, Johannes Korth, Adalbert Krawczyk, Benjamin Wilde, Peter A. Horn, Oliver Witzke, Monika Lindemann, Melanie Fiedler Source Type: research
Development of a standardized real time PCR for Torque Teno Viruses (TTV) viral load detection and quantification: a new tool for immune monitoring
TTV replication is closely linked to immune status modifications and viral load is now considered as a potential tool for the follow-up of immune status in post transplantation patients. TTV potential as an immunosuppression biomarker has been recently underlined by several publications in various clinical settings [1 –5]. TTV are small DNA viruses discovered in 1997 that represent the most abundant component of the human virome [5]. TTV is ubiquitous and highly prevalent in the general population worldwide [6], with 90% of the human population infected and so far, not associated with a pathology or clinical di sease [7,...
Source: Journal of Clinical Virology - June 11, 2018 Category: Virology Authors: Dorian Kulifaj, B énédicte Durgueil-Lariviere, Faustine Meynier, Eliza Munteanu, Nicolas Pichon, Manon Dube, Martine Joannes, Marie Essig, Sébastien Hantz, Côme Barranger, Sophie Alain Source Type: research
Evaluation of In Vitro Screening and Diagnostic Kits for Hepatitis C Virus Infection
Currently, many in vitro diagnostic kits to screen and detect HCV infection are available in Japan and other countries. Although these kits are inspected by the National Regulatory Authority in each country to verify their qualities before release to the market, post-marketing surveillance is important to ensure the continued performance of these kits because predominant genotypes or strains may change over time. For this purpose, assessment using International Standards and a regional reference panel (RRP) are desirable. (Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - June 11, 2018 Category: Virology Authors: Haruka Momose, Sahoko Matsuoka, Asako Murayama, Norie Yamada, Kazu Okuma, Emi Ikebe, Yuji Hoshi, Masamichi Muramatsu, Takaji Wakita, Kuro Toyota, Takanobu Kato, Isao Hamaguchi Source Type: research
Novel score predicts risk for cytomegalovirus infection in ulcerative colitis
Inflammatory bowel diseases (IBD) such as ulcerative colitis (UC) are affecting increasing numbers of patients in the industrialized world with current prevalence rates UC exceeding 200 – 250/100.000 [1]. Cytomegalovirus (CMV) infections, are associated with UC aggravation complicating disease management or as a complication of the treatment itself [2,3]. The prevalence of CMV colitis in UC patients has been estimated to range from 21% to 36% [4,5]. (Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - June 9, 2018 Category: Virology Authors: Tobias M. Nowacki, Dominik Bettenworth, Tobias Meister, Jan Heidemann, Frank Lenze, Hartmut H. Schmidt, Hauke S. Heinzow Source Type: research
Detection of Norovirus by BD MAX ™, Xpert® Norovirus, and xTAG® Gastrointestinal Pathogen Panel in Stool and Vomit Samples
Norovirus is a small, non-enveloped, positive stranded RNA virus in the Caliciviridae family. Infection results in diarrhoea, vomiting, abdominal pain and fever lasting 1-3 days, although only 10-12% of individuals seek medical attention [1]. Norovirus is the most common cause of acute gastroenteritis worldwide and causes outbreaks in hospitals, nursing homes, cruise ships, and other closed settings [2 –5]. There are an estimated 19-21 million norovirus cases in the United States every year [6]. Outbreaks of norovirus not only confer significant morbidity but have also been shown to increase all-cause mortality, particul...
Source: Journal of Clinical Virology - June 8, 2018 Category: Virology Authors: Martin P. McHugh, Daniel Guerendiain, Alison Hardie, Juliet Kenicer, Laura MacKenzie, Kate E. Templeton Source Type: research
Respiratory viruses among children with non-severe community-acquired pneumonia: a prospective cohort study
Community-acquired pneumonia (CAP) among children under-5 years old causes a major burden to health care systems worldwide [1], where it is estimated the occurrence of 156 million new CAP cases annually in this age range [2]. Therefore, effective measures to control this condition are demanded [3]. (Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - June 6, 2018 Category: Virology Authors: Amanda C. Nascimento-Carvalho, Ana-Luisa Vilas-Boas, Maria-Socorro H. Fontoura, Tytti Vuorinen, Cristiana M. Nascimento-Carvalho, the PNEUMOPAC-Efficacy Study Group Source Type: research
An unusual outbreak of rotavirus G8P[8] gastroenteritis in adults in an urban community, Singapore, 2016
Rotavirus was first discovered by Bishop et al in 1973 [1], who described the unique viral particles isolated from the duodenal mucosa of children. Of the seven distinct groups of rotavirus (named A to G), groups A, B, and C have been reported to cause human infections [2]. Rotaviruses, especially those from group A, were considered to be the main cause of viral gastroenteritis (GE) in infants and young children around the world, causing approximately 111 million episodes of GE per year in children under 5 years of age [3]. (Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - June 6, 2018 Category: Virology Authors: Gabriel Chia, Hanley Ho, Ching-Ging Ng, Freddy Jun-Xian Neo, Mar-Kyaw Win, Lin Cui, Yee-Sin Leo, Angela Chow Source Type: research
Editorial Board
(Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - June 5, 2018 Category: Virology Source Type: research
ESCV Membership
(Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - June 5, 2018 Category: Virology Source Type: research
PASCV Membership
(Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - June 5, 2018 Category: Virology Source Type: research
Genome-wide linear B-cell epitopes of enterovirus 71 in a hand, foot and mouth disease (HFMD) population
Enteroviruses, such as enterovirus 71 (EV71), coxasckievirus A6 (CAV6) [1], coxasckievirus A16 (CAV16) and coxasckievirus A10 (CAV10) [2] cause Hand, foot and mouth disease (HFMD) that is associated with herpangina, severe neurological complications and even fatalities in infants and young children worldwide [3 –9]. EV71 is one of the major agents and can cause severe complications and death in children [3]. (Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - June 3, 2018 Category: Virology Authors: Huiying Zhang, Zhigang Song, Huiju Yu, Xiaoling Zhang, Shanshan Xu, Zhong Li, Jingzhi Li, Hongke Xu, Zhenghong Yuan, Hongwei Ma, Zhigang Yi, Yunwen Hu Source Type: research
