Editorial Board
(Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - August 22, 2018 Category: Virology Source Type: research
ESCV Membership
(Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - August 22, 2018 Category: Virology Source Type: research
PASCV Membership
(Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - August 22, 2018 Category: Virology Source Type: research
Ongoing and emerging arbovirus threats in Europe
During the last decades, arboviruses that are endemic in Europe have expanded their geographic range and caused an increasing number of human outbreaks. These viruses include West Nile virus, which is expanding its area of circulation in central and southern Europe; Usutu virus, with increasing evidence of a role in human disease; tick-borne encephalitis virus, which is being detected in northern areas and at higher altitudes as a consequence of climate warming; Crimean-Congo hemorrhagic fever virus, which is endemic in Eastern Europe and the Middle East, but has been recently detected in Spain; other viruses, such as Cali...
Source: Journal of Clinical Virology - August 22, 2018 Category: Virology Authors: Luisa Barzon Source Type: research
VALHUDES: a protocol for validation of human papillomavirus assays and collection devices for HPV testing on self-samples and urine samples
Offering devices which allow women to take a self-sample may increase uptake for cervical cancer screening among particularly those who do not participate in the regular programme. Several studies have shown that mailing a self-sampling kit to the women's home address generates a greater response compared to mailing of reminder letters recommending collection of a cervical sample by a health professional[1,2]. However, the magnitude of this response gain is very heterogeneous across studies, which suggests that the impact of self-sampling depends on local conditions, context and the design of the screening programme[2]. (S...
Source: Journal of Clinical Virology - August 22, 2018 Category: Virology Authors: M. Arbyn, E. Peeters, I. Benoy, D. Vanden Broeck, J. Bogers, P. De Sutter, G. Donders, W. Tjalma, S. Weyers, K. Cuschieri, M. Poljak, J. Bonde, C. Cocuzza, F.H. Zhao, S. Van Keer, A. Vorsters Source Type: research
Comparing molecular quantification of herpes simplex virus (HSV) in cerebrospinal fluid (CSF) with quantitative structural and functional disease severity in patients with HSV encephalitis (HSVE): implications for improved therapeutic approaches
HSV is the most common identified cause of severe and fatal infectious encephalitis, accounting for approximately 10 –20% of all viral encephalitis cases in the United States [1]. The incidence of neonatal HSV infection is similar to that of serious bacterial infection amongst young infants evaluated for sepsis [2]. Despite antiviral therapy, the morbidity and mortality of HSVE remains unacceptably high; up to 6 9% of neonates and 44-62% of children and adults will suffer long-term neurological impairment [3,4]. (Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - August 18, 2018 Category: Virology Authors: Kacy A. Ramirez, Asim F. Choudhri, Anami Patel, Noel T. Lenny, Rebecca E. Thompson, Leslie Berkelhammer Greenberg, Nancy Clanton Watson, Mehmet Kocak, John P. DeVincenzo Source Type: research
Characterization of human parainfluenza virus-3 circulating in Israel, 2012-2015
Human parainfluenza virus 3 (hPIV-3), a memberof the Paramyxoviridae family, is an enveloped single stranded RNA virus with negative polarity [1]. hPIV-3 causes a spectrum of respiratory tracts infections ranging from asymptomatic upper respiratory infection in young children [2], to severe illness like bronchiolitis and pneumonia in infants [1]. hPIV-3 has also been reported to cause severe health care associated infection in newborn nurseries, bone marrow transplant and hematology-oncology units [2 –5]. (Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - August 13, 2018 Category: Virology Authors: Irina Jornist, Khitam Muhsen, Daniela Ram, Yaniv Lustig, Virginia Levy, Sara Orzitser, Roberto Azar, Merav Weil, Viki Indenbaum, Danit Sofer, Ella Mendelson, Michal Mandelboim, Musa Hindiyeh Source Type: research
WU Polyomavirus Detected in Children with Severe Respiratory Failure
WU polyomavirus (WUPyV) is a relatively new human polyomavirus first detected in respiratory samples in 2007 [1]. It has since then been detected in respiratory tract samples in both immunocompetent and immunocompromised patients worldwide [2 –7]. However, its pathogenic role remains unclear, especially in pediatric patients with severe respiratory failure. (Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - August 9, 2018 Category: Virology Authors: Kazuhiro Uda, Chitose Koyama-Wakai, Kensuke Shoji, Noriyasu Iwase, Daisuke Motooka, Shota Nakamura, Isao Miyairi Source Type: research
History of Matrix Genes Mutations within PCR Target Regions Among Circulating Influenza H3N2 Clades over Ten-Plus-Years
Emerging influenza A/H3N2 clades have been associated with M1 gene mutations which affect the performance of commercial PCR assays. (Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - August 8, 2018 Category: Virology Authors: Kathleen A. Stellrecht Source Type: research
Hepatitis E infection in stem cell and solid organ transplantpatients: A cross-sectional study
Hepatitis E Virus (HEV) is a common cause of infectious hepatitis [1]. Of the four major genotypes infecting humans, genotype 3 (G3) has been solely implicated in HEV cases in England. HEV infection can persist in immunosuppressed patients, leading to chronic hepatitis, cirrhosis [2,3] or development of other syndromes, including neurological disorders [4,5]. Epidemiologic data demonstrate a recent increased incidence in the U.K. [2] and variable prevalence across Europe [6]. HEV prevalence of 0.04% in blood donors from England [7] led to introduction of universal screening for HEV RNA in donors of blood, tissue, stem-cell...
Source: Journal of Clinical Virology - July 28, 2018 Category: Virology Authors: Ian Reekie, Dianne Irish, Samreen Ijaz, Thomas Fox, Tehmina Bharucha, Paul Griffiths, Douglas Thorburn, Mark Harber, Stephen MacKinnon, Mallika Sekhar Tags: Short communication Source Type: research
Hepatitis E infection in stem cell and solid organ transplant patients: a cross-sectional study
Hepatitis E Virus (HEV) is a common cause of infectious hepatitis [1]. Of the four major genotypes infecting humans, genotype 3 (G3) has been solely implicated in HEV cases in England. HEV infection can persist in immunosuppressed patients, leading to chronic hepatitis, cirrhosis [2,3] or development of other syndromes, including neurological disorders [4,5]. Epidemiologic data demonstrate a recent increased incidence in the U.K. [2] and variable prevalence across Europe [6]. HEV prevalence of 0.04% in blood donors from England [7] led to introduction of universal screening for HEV RNA in donors of blood, tissue, stem-cell...
Source: Journal of Clinical Virology - July 28, 2018 Category: Virology Authors: Ian Reekie, Dianne Irish, Samreen Ijaz, Thomas Fox, Tehmina Bharucha, Paul Griffiths, Douglas Thorburn, Mark Harber, Stephen MacKinnon, Mallika Sekhar Tags: Short communication Source Type: research
Cellular DNA quantification in respiratory samples for the normalization of viral load: a real need?
Respiratory tract infections (RTI) have an enormous social and economic impact, with a high incidence of hospitalization and high public health care costs [1]. Because of similar clinical symptoms and simultaneous circulation of several different viruses, their etiology is often difficult to determine. Adequate specimen collection is the first crucial step for the correct diagnosis of influenza and other respiratory infections. Dilution correction in nasopharyngeal aspirates might improve the detection of respiratory infections [2]. (Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - July 27, 2018 Category: Virology Authors: Antonio Piralla, Federica Giardina, Francesca Rovida, Giulia Campanini, Fausto Baldanti Source Type: research
Evolution of HIV-1 transmitted drug resistance in Italy in the 2007 –2014 period: A weighted analysis
Transmitted drug resistance (TDR) represents a major concern for the efficacy of combined antiretroviral therapy (cART) [1], even showing a stable or even decreasing trend in Europe before 2010 [2,3]. This evidence may be explained at least in part by the stable and marked decrease observed in the frequency of acquired resistance, which has been observed in several clinical settings over the last decade [4 –6]. HIV-1 infected populations with different epidemiological characteristics, mainly related to the route of infection and the country of origin may be disproportionally affected by TDR [7–9]. (Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - July 26, 2018 Category: Virology Authors: M. Franzetti, A. De Luca, F. Ceccherini-Silberstein, V. Spagnuolo, E. Nicastri, C. Mussini, A. Antinori, L. Monno, J. Vecchiet, I. Fanti, A. d ’Arminio Monforte, C. Balotta, on behalf of the ICONA Foundation Study Group Tags: Short communication Source Type: research
Quantification of total HIV-1 DNA in buffy coat cells, feasibility and potential added value for clinical follow-up of HIV-1 infected patients on ART
Today, antiretroviral therapy (ART) is initiated immediately after HIV-1 diagnosis. As a result, most patients have an undetectable HIV-1 RNA load for prolonged periods of time. Quantification of total HIV-1 DNA in peripheral blood mononuclear cells (PBMC) is applied as a surrogate marker for the size of the HIV reservoir in several HIV cure studies [1,2]. In patients on ART, the HIV-1 DNA load may reflect the overall viral burden and therefore constitute a potentially interesting marker for clinical follow-up. (Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - July 26, 2018 Category: Virology Authors: Virginie Mortier, Els Demecheleer, Delfien Staelens, Marlies Schauvliege, Kenny Dauwe, Sylvie Dinakis, Laura Hebberecht, Leen Vancoillie, Chris Verhofstede Source Type: research
Evolution of HIV-1 Transmitted Drug Resistance in Italy in the 2007-2014 Period: a Weighted Analysis
Transmitted drug resistance (TDR) represents a major concern for the efficacy of combined antiretroviral therapy (cART) [1], even showing a stable or even decreasing trend in Europe before 2010 [2 –3]. This evidence may be explained at least in part by the stable and marked decrease observed in the frequency of acquired resistance, which has been observed in several clinical settings over the last decade [4,5,6]. HIV-1 infected populations with different epidemiological characteristics, mai nly related to the route of infection and the country of origin may be disproportionally affected by TDR [7–9]. (Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - July 26, 2018 Category: Virology Authors: M. Franzetti, A. De Luca, F. Ceccherini-Silberstein, V. Spagnuolo, E. Nicastri, C. Mussini, A. Antinori, L. Monno, J. Vecchiet, I. Fanti, A. d ’Arminio Monforte, C. Balotta, on behalf of the ICONA Foundation Study Group Tags: Short communication Source Type: research
