Substantial variation in the hepatitis B surface antigen (HBsAg) in hepatitis B virus (HBV)-positive patients from South Africa: Reliable detection of HBV by the Elecsys HBsAg II assay
Chronic hepatitis B virus (HBV) infection affects nearly 250 million people worldwide and can lead to long-term complications, such as liver cirrhosis, hepatic failure, and hepatocellular carcinoma [1,2]. HBV is differentiated into 10 genotypes (A –J) based on differences in genome sequence of more than 8%. The currently known HBV genotypes vary in their ethno-geographic distribution and exhibit differences in their genetic variation patterns, disease chronicity, and their response to antiviral treatment [3]. (Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - March 10, 2018 Category: Virology Authors: Mikael Gencay, Marion Vermeulen, Dionysis Neofytos, Gaston Westergaard, Stephan Pabinger, Albert Kriegner, Anja Seffner, Peter Gohl, Kirsten Huebner, Markus Nauck, Wolfgang E. Kaminski Source Type: research
Editorial Board
(Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - March 10, 2018 Category: Virology Source Type: research
ESCV Membership
(Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - March 10, 2018 Category: Virology Source Type: research
PASCV Membership
(Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - March 10, 2018 Category: Virology Source Type: research
Interferon lambda receptor 1 (IFNL1R) transcript is highly expressed in rhinovirus bronchiolitis and correlates with disease severity
It is well established that both respiratory syncytial virus (RSV) and human rhinovirus (HRV) are the leading causes of respiratory tract disease in early childhood. Both infections are associated with acute bronchiolitis, pneumonia, and asthma exacerbations, yet the mechanisms regulating the host immune response to both viruses are poorly understood [1,2]. The mucosal innate immune system provides a strong barrier to respiratory viral infections, including RSV and HRV. In particular, viral infection with RSV or HRV can induce the concomitant production of type I (IFN α/β) and type III (IFNλs) [3–5]. (Source: Journal ...
Source: Journal of Clinical Virology - March 10, 2018 Category: Virology Authors: Alessandra Pierangeli, Maura Statzu, Raffaella Nenna, Letizia Santinelli, Laura Petrarca, Antonella Frassanito, Massimo Gentile, Guido Antonelli, Fabio Midulla, Carolina Scagnolari Source Type: research
Interferon lambda receptor 1 (IFNL1R) transcript is highly expressed in rhinovirus bronchiolitis and correlates with disease severity
It is well established that both respiratory syncytial virus (RSV) and rhinovirus (HRV) are the leading causes of respiratory tract disease in early childhood. Both infections are associated with acute bronchiolitis, pneumonia, and asthma exacerbations, yet the mechanisms regulating the host immune response to both viruses are poorly understood [1,2]. The mucosal innate immune system provides a strong barrier to respiratory viral infections, including RSV and HRV. In particular, viral infection with RSV or HRV can induce the concomitant production of type I (IFN α/β) and type III (IFNλs) [3–5]. (Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - March 10, 2018 Category: Virology Authors: Alessandra Pierangeli, Maura Statzu, Raffaella Nenna, Letizia Santinelli, Laura Petrarca, Antonella Frassanito, Massimo Gentile, Guido Antonelli, Fabio Midulla, Carolina Scagnolari Source Type: research
Primary Epstein-Barr virus infection
Epstein-Barr virus (EBV) is arguably the most ubiquitous of human viruses, infecting at least 90% of adults worldwide [1]. It is also the first human cancer virus, having been recognized as the cause of endemic Burkitt lymphoma in the 1960s [2 –4]. In addition to Burkitt lymphoma, EBV is implicated in the pathogenesis of Hodgkin lymphoma [5], nasopharyngeal carcinoma [6,7], gastric cancer [8], and a myriad of malignancies in individuals with inherited or acquired immunodeficiency [9]. EBV is also considered to be a major environmental r isk factor for multiple sclerosis [10]. (Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - March 5, 2018 Category: Virology Authors: Samantha K. Dunmire, Priya S. Verghese, Henry H. Balfour Tags: Review Source Type: research
Do asymptomatic respiratory viral infections occur?
Viral respiratory infections can cause wide symptom-severity ranges. Detecting community-acquired respiratory-viruses by amplified molecular methods is becoming routine and such results form components of many research studies [1]. Using these technologies, multiple respiratory-viruses can be detected simultaneously within the same symptomatic patient. However, relatively little attention has been given to the detection of respiratory-viruses within asymptomatic populations [2]. Furthermore, the data describing the detection of respiratory-viruses from “asymptomatic” individuals often fail to define “asymptomatic” ...
Source: Journal of Clinical Virology - March 5, 2018 Category: Virology Authors: Ryan H. Tomlinson, Lisa G. Harrison, Elizabeth A. Meals, John P. DeVincenzo Source Type: research
Primary Epstein-Barr virus infection
Epstein-Barr virus (EBV) is arguably the most ubiquitous of human viruses, infecting at least 90% of adults worldwide [1]. It is also the first human cancer virus, having been recognized as the cause of endemic Burkitt lymphoma in the 1960s [2 –4]. In addition to Burkitt lymphoma, EBV is implicated in the pathogenesis of Hodgkin lymphoma [5], nasopharyngeal carcinoma [6,7], gastric cancer [8], and a myriad of malignancies in individuals with inherited or acquired immunodeficiency [9]. EBV is also considered to be a major environmental r isk factor for multiple sclerosis [10]. (Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - March 5, 2018 Category: Virology Authors: Samantha K. Dunmire, Priya S. Verghese, Henry H. Balfour Tags: Review Source Type: research
Do asymptomatic respiratory viral infections occur?
Viral respiratory infections can cause wide symptom-severity ranges. Detecting community-acquired respiratory-viruses by amplified molecular methods is becoming routine and such results form components of many research studies [1]. Using these technologies, multiple respiratory-viruses can be detected simultaneously within the same symptomatic patient. However, relatively little attention has been given to the detection of respiratory-viruses within asymptomatic populations [2]. Furthermore, the data describing the detection of respiratory-viruses from “asymptomatic” individuals often fail to define “asymptomatic” ...
Source: Journal of Clinical Virology - March 5, 2018 Category: Virology Authors: Ryan H. Tomlinson, Lisa G. Harrison, Elizabeth A. Meals, John P. DeVincenzo Source Type: research
An analysis of the predictive value of the HIV Ag/Ab screening assay within the performance characteristics of the DiaSorin LIAISON XL for the detection of blood-borne viruses
Blood-borne viral infections such as hepatitis B virus (HBV), hepatitis C virus (HCV), and the human immunodeficiency virus (HIV) are highly transmissible, can potentially lead to chronic or fatal outcome and thus pose a relevant threat in infectious disease control and blood transfusions [1 –3]. Screening for blood-borne viral infections requires the use of fully automatic diagnostic test systems for which the requirements are particularly high. These requirements vary according to the prevalence of blood-borne viral infections in the study population. (Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - February 27, 2018 Category: Virology Authors: Khoa T.D. Thai, Hannelore G ötz, Bibi C.G.C. Slingerland, Janienne Klaasse, Martin Schutten, Corine H. GeurtsvanKessel Source Type: research
Reactivation of BK polyomavirus during pregnancy, vertical transmission, and clinical significance: A meta-analysis
BK Polyomavirus is a small double-stranded circular DNA virus in the Polyomaviridae family, infecting a substantial proportion of humans worldwide [1 –3]. Primary infection with BK virus occurs during early childhood and is usually asymptomatic [1]. BK seroprevalence increases with age (approximately 70% of children are infected by the age of 10 years, and greater than 80% of adults become BK seropositive) [1,4]. In immunosuppressed states, esp ecially after kidney transplantation, reactivation of BK virus can cause BK viremia and BK nephropathy, associated with allograft loss [3]. (Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - February 24, 2018 Category: Virology Authors: Wisit Cheungpasitporn, Charat Thongprayoon, Iasmina M. Craici, Konika Sharma, Supavit Chesdachai, Nadeen J. Khoury, Amy S. Ettore Source Type: research
Performance of the OraQuick Hepatitis C virus antibody test in oral fluid and fingerstick blood before and after treatment-induced viral clearance
Chronic hepatitis C Virus (HCV) infection leading to cirrhosis has been the main liver transplant indication for the last 15 years, before the availability of direct-acting antivirals (DAA). HCV still represents considerable economic burden on health systems worldwide with an estimated 71 million people chronically infected [1 –3] and 700,000 annual deaths because of untreated chronic infection [4]. In the United States, the Centers for Disease Control and Prevention (CDC) has recommended screening in individuals considered to be at high risk of contracting the infection [5,6]. (Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - February 24, 2018 Category: Virology Authors: Carmina Pallar és, Ângela Carvalho-Gomes, Vanessa Hontangas, Isabel Conde, Tomasso Di Maira, Victoria Aguilera, Salvador Benlloch, Marina Berenguer, F. Xavier López-Labrador Source Type: research
Diagnosis and monitoring of HCV infection using the cobas ® HCV test for use on the cobas® 6800/8800 systems
Chronic hepatitis C virus (HCV) infection is a significant threat to global public health. Worldwide, 71 million people are estimated to be affected [1], and the progressive liver damage that can ensue has severe consequences including cirrhosis, liver failure and hepatocellular carcinoma [2,3]. The landscape of chronic hepatitis C changed dramatically with the introduction of oral, direct acting antiviral (DAA) drugs. These regimens are well tolerated, can be administered for short duration, and are highly effective, producing cure (sustained virologic response, “SVR”) in>95% of treated individuals, across almost all ...
Source: Journal of Clinical Virology - February 24, 2018 Category: Virology Authors: Joseph D. Yao, Stephen Young, Gabrielle M. Heilek, Enrique Marino, Ellen E. Paxinos, Ed G. Marins, Alexandra Valsamakis Source Type: research
