Interferon lambda receptor 1 (IFNL1R) transcript is highly expressed in rhinovirus bronchiolitis and correlates with disease severity

It is well established that both respiratory syncytial virus (RSV) and rhinovirus (HRV) are the leading causes of respiratory tract disease in early childhood. Both infections are associated with acute bronchiolitis, pneumonia, and asthma exacerbations, yet the mechanisms regulating the host immune response to both viruses are poorly understood [1,2]. The mucosal innate immune system provides a strong barrier to respiratory viral infections, including RSV and HRV. In particular, viral infection with RSV or HRV can induce the concomitant production of type I (IFN α/β) and type III (IFNλs) [3–5].

Source: Journal of Clinical Virology - March 10, 2018 Category: Virology Authors: Alessandra Pierangeli, Maura Statzu, Raffaella Nenna, Letizia Santinelli, Laura Petrarca, Antonella Frassanito, Massimo Gentile, Guido Antonelli, Fabio Midulla, Carolina Scagnolari Source Type: research