Evaluation of the performance of a new automated HIV combination assay
In 1997, combination assays, termed “fourth-generation” EIAs, which detect both HIV-1 p24 antigen (Ag) and antibodies (Ab), became available in Europe, allowing the detection of early as well as established infections [1]. Since this time, more than 10 different fourth-generation assays have been licensed in Europe. These combinat ion assays reduce the seroconversion window period by 4–8days when compared to third generation EIAs, which only detect HIV antibodies [2,3]. European legislation requires that commercially available assays now need to detect both HIV-1 p24 antigen and HIV-1 and HIV-2 antibodies, with sensi...
Source: Journal of Clinical Virology - September 21, 2017 Category: Virology Authors: Valeria Ghisetti, Catherine Coignard, Tiziano Allice, Ly Thoai Duong Tags: Full length article Source Type: research
Editorial Board
(Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - September 20, 2017 Category: Virology Source Type: research
ESCV Membership
(Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - September 20, 2017 Category: Virology Source Type: research
PASCV Membership
(Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - September 20, 2017 Category: Virology Source Type: research
Evaluation of Clinical Sensitivity and Specificity of Hepatitis B Virus (HBV), Hepatitis C Virus, and Human Immunodeficiency Virus-1 by cobas MPX: Detection of Occult HBV Infection in an HBV-endemic Area
Transfusion-transmitted infectious diseases remain a major concern for blood safety, particularly with hepatitis B virus (HBV), hepatitis C virus (HCV), and human immunodeficiency virus (HIV). To reduce the risk of transfusion-transmitted viral infection, serologic screening was commonly performed in the past, although infectious blood units from donors in the window period could still be transfused [1]. Nucleic acid testing (NAT) in donor screening has shortened the serologically negative window period and reduced virus transmission [2,3]. (Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - September 20, 2017 Category: Virology Authors: Jihye Ha, Younhee Park, Hyon-suk Kim Tags: Full length article Source Type: research
Multicenter comparison of the new Cobas 6800 system with Cobas Ampliprep/Cobas TaqMan and Abbott RealTime for the quantification of HIV, HBV and HCV viral load
Viral load (VL) quantification is an essential element for the monitoring of patients infected with viruses, such as the human immunodeficiency virus (HIV), hepatitis B (HBV) and C viruses (HCV). Various commercial VL assays based on different technologies are available. New integrated fully automated molecular testing platforms have recently been developed, making it possible to determine VL for different viruses simultaneously, with a higher throughput than for previous devices [1 –5]. This is the case for the new Cobas 6800/8800 system (C6800; Roche Diagnostics, Mannheim, Germany) available since 2014 as an alternativ...
Source: Journal of Clinical Virology - September 19, 2017 Category: Virology Authors: Marc Wirden, Lucile Larrouy, Nadia Mahjoub, Eve Todesco, Florence Damond, Heloise Delagreverie, Sepideh Akhavan, Charlotte Charpentier, Marie-Laure Chaix, Diane Descamps, Vincent Calvez, Anne-Genevieve Marcelin Tags: Full length article Source Type: research
Super-infections and relapses occur in chronic norovirus infections
Norovirus is a leading cause of gastroenteritis. Infections are typically self-limiting in immunocompetent hosts, with limited morbidity aside from dehydration. In immunocompromised patients however, there is a risk of chronic infection with significant associated morbidity [1]. Chronic infections are bi-phasic with an acute phase of vomiting and diarrhoea, followed by chronic viral shedding and diarrhoea lasting weeks to years. The majority of case reports describe patients to be symptomatic during this extended period of shedding, with up to 24 bowel movements per day [2]. (Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - September 19, 2017 Category: Virology Authors: Julianne R Brown, Sunando Roy, Helena Tutill, Rachel Williams, Judith Breuer Tags: Short communication Source Type: research
Outcomes of congenital cytomegalovirus disease following maternal primary and non-primary infection
Congenital cytomegalovirus (cCMV) infection is a common cause of neurodevelopmental disabilities [1]. Unlike other perinatal infections as congenital rubella or toxoplasmosis, CMV maternal immunity acquired prior to conception does not ensure a complete protection of fetus from infection [2 –6]. Approximately 40% of women experiencing a CMV primary infection during pregnancy will transmit virus to their fetus. Of the infants infected in utero, about 10% will exhibit some symptoms at birth that are consistent with cCMV symptomatic infection [6]. (Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - September 13, 2017 Category: Virology Authors: Antonietta Giannattasio, Pasquale Di Costanzo, Arianna De Matteis, Paola Milite, Daniela De Martino, Laura Bucci, Maria Rosaria Augurio, Carmela Bravaccio, Teresa Ferrara, Letizia Capasso, Francesco Raimondi Tags: Full length article Source Type: research
Rotavirus genotype shifts among Swedish children and adults —Application of a real-time PCR genotyping
Rotavirus is a major cause of acute gastroenteritis in young children worldwide, leading to approximately 500,000 deaths every year [1]. In high-income countries, the mortality of rotavirus infections is low but there is still considerable morbidity in infants, generating significant health costs [2,3]. (Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - September 9, 2017 Category: Virology Authors: Maria Andersson, Magnus Lindh Tags: Full length article Source Type: research
Clinical, laboratory and virological data from suspected ZIKV patients in an endemic arbovirus area
Since 2015, Brazil is facing the challenge of the co-circulation of three arboviruses of major public health importance [1]. For the last 30 years, Dengue virus (DENV) infection has been the main mosquito-transmitted threat in the country, which has suffered several epidemics caused by all four serotypes, and fostered by the widespread presence of its main vector, Aedes aegypti, in densely populated urban areas [2 –4]. In spite of all efforts, a sustained reduction of the Aedes aegypti population has not been achieved [5–7]. (Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - September 9, 2017 Category: Virology Authors: Tatiana Elias Colombo, C ássia Fernanda Estofolete, Andréia Francesli Negri Reis, Natal Santos da Silva, Morgana Lima Aguiar, Eliana Márcia Sotello Cabrera, Izalco Nuremberg Penha dos Santos, Fabiana Rodrigues Costa, Lilian Elisa Arão Antônio Cruz, P Source Type: research
Rotavirus genotype shifts among Swedish children and adults − application of a real-time PCR genotyping
Rotavirus is a major cause of acute gastroenteritis in young children worldwide, leading to approximately 500,000 deaths every year [1]. In high-income countries, the mortality of rotavirus infections is low but there is still considerable morbidity in infants, generating significant health costs [2,3]. (Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - September 9, 2017 Category: Virology Authors: Maria Andersson, Magnus Lindh Tags: Full length article Source Type: research
BK virus replication in renal transplant recipients: Analysis of potential risk factors may contribute in reactivation
Although the name of BK virus has rarely been mentioned as a pathogenic agent in some extra-renal human diseases, it has been strongly known as a significant viral infection related to nephropathy and renal graft-failure in kidney transplant recipients [1]. The first isolation of BK virus was carried out by Gardner et al. in 1971 [2], and thereafter its clinical importance was demonstrated by Mackenzie et al. in 1978 [3]. It has been reported that 60-90% of healthy populations become seropositive by the age of 10 [4 –7]. (Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - September 8, 2017 Category: Virology Authors: Mohammad Shenagari, Ali Monfared, Hadise Eghtedari, Aydin Pourkazemi, Tolou Hasandokht, Masoud Khosravi, Babak Asharfkhani Source Type: research
Respiratory syncytial virus hospitalization in middle-aged and older adults
Respiratory Syncytial Virus (RSV), commonly regarded as a childhood infection, is also an important contributor to respiratory illness among adults [1 –8]. However, unlike influenza, in which serious morbidity has been clearly recognized for years, the relative impact of RSV infection in adults has more recently gained widespread recognition [9,10]. While primary RSV infections in infancy can result in severe disease, subsequent infections are o ften comparatively mild. Incomplete immunity results in continued susceptibility to reinfection through life. (Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - September 7, 2017 Category: Virology Authors: Ryan E. Malosh, Emily T. Martin, Amy P. Callear, Joshua G. Petrie, Adam Lauring, Lois Lamerato, Alicia M. Fry, Jill Ferdinands, Brendan Flannery, Arnold S. Monto Tags: Full length article Source Type: research
Type 1 diabetes and viral infections: what is the relationship?
Type 1 diabetes (T1D) is the most common chronic metabolic disorder in children. However, the incidence of childhood onset T1D varies significantly between and within countries, ranging from 0.1 cases in Venezuela to more than 40 cases in Finland per 100,000/year [1]. Lower incidence rates are observed in Asia, Africa, and Central and South America, whereas higher rates have been evidenced in northern Europe, North America, New Zealand, and Australia. In Italy, a single region — Sardinia —has a T1D incidence rate that is more than three times higher than that in other parts of the country (37.8 vs 10 per 100,000/year) ...
Source: Journal of Clinical Virology - September 7, 2017 Category: Virology Authors: Nicola Principi, Maria Giulia Berioli, Sonia Bianchini, Susanna Esposito Tags: Review Source Type: research
HIGH CMV IgG ANTIBODY LEVELS ARE ASSOCIATED TO A LOWER CD4+ RESPONSE TO ANTIRETROVIRAL THERAPY IN HIV-INFECTED WOMEN
In sub-Saharan Africa the great majority of women are infected with cytomegalovirus (CMV) [1]. CMV infection has been shown to have a significant impact on HIV disease course: in one study CMV infection was associated with an increased risk of severe non-AIDS-defining events in a large cohort of HIV-infected patients [2]; recently, levels of specific CMV IgG have been shown to be associated with disease progression and immune activation in untreated women in Uganda [3]. Studies have been also performed to evaluate the impact of CMV infection on lymphocytes. (Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - September 5, 2017 Category: Virology Authors: Marina Giuliano, Maria Franca Pirillo, Giuseppe Liotta, Mauro Andreotti, Haswell Jere, Jean-Baptiste Sagno, Fausto Ciccacci, Roberta Amici, Maria Cristina Marazzi, Stefano Vella, Leonardo Palombi, Sandro Mancinelli Tags: Short communication Source Type: research
