Use of Laboratory Tests to Guide Initiation of Autologous Hematopoietic Progenitor Cell Collection by Apheresis: Results From the Multicenter Hematopoietic Progenitor Cell Collection by Apheresis Laboratory Trigger Survey
Limited literature describes the value of laboratory “triggers” to guide collection of peripheral blood (PB) hematopoietic progenitor cells (HPCs) by apheresis [HPC(A)]. We used a web-based survey to determine which parameters are used to initiate autologous HPC(A) collection in adult and pediatric patients and to identify common practice patterns. Members of the AABB Cellular Therapy Product Collection and Clinical Practices Subsection and the American Society for Apheresis HPC Donor Subcommittee drafted and developed relevant survey questions. (Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - September 4, 2014 Category: Hematology Authors: Robert S. Makar, Anand Padmanabhan, Haewon C. Kim, Christina Anderson, Michele W. Sugrue, Michael Linenberger Source Type: research
A Mechanistic Approach to the Diagnosis and Management of Atypical Hemolytic Uremic Syndrome
Until recently, atypical hemolytic uremic syndrome (aHUS), conventionally defined in the pediatric literature as a syndrome of the triad of renal failure, microangiopathic hemolytic anemia, and thrombocytopenia without a prodrome of hemorrhagic diarrhea, has received little attention in adult practice because the patients are commonly given the diagnosis of thrombotic thrombocytopenic purpura (TTP) or TTP/HUS and treated as TTP with plasma exchange, augmented in refractory cases with rituximab and sometimes even splenectomy. (Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - September 3, 2014 Category: Hematology Authors: Han-Mou Tsai Source Type: research
Extended Blood Group Molecular Typing and Next-Generation Sequencing
Several high-throughput multiplex blood group molecular typing platforms have been developed to predict blood group antigen phenotypes. These molecular systems support extended donor/patient matching by detecting commonly encountered blood group polymorphisms as well as rare alleles that determine the expression of blood group antigens. Extended molecular typing of a large number of blood donors by high-throughput platforms can increase the likelihood of identifying donor red blood cells that match those of recipients. (Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - August 28, 2014 Category: Hematology Authors: Zhugong Liu, Meihong Liu, Teresita Mercado, Orieji Illoh, Richard Davey Source Type: research
Dengue Virus Persists in Stored Platelets and Red Blood Cells
Dengue virus (DENV), a positive-sense single-stranded RNA Flavivirus, infects ~390 million people annually. Significant viral load is seen in asymptomatic individuals resulting in transfusion-transmission and a threat to blood systems globally. It is currently unknown whether DENV can maintain its viability or even replicate during storage of cellular blood products. Therefore, we investigated the persistence of DENV (serotypes 1-4) in stored platelet (PC) and red blood cell concentrates (RCC) under standard blood bank conditions. (Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - July 1, 2014 Category: Hematology Authors: Michael R. Sutherland, Ayo Y. Simon, Katherine Serrano, Peter Schubert, Jason Acker, Ed L.G. Pryzdial Tags: Abstracts Source Type: research
Use of Prothrombin Complex Concentrates in Patients with Hepatic Coagulopathy: A Single Center Retrospective Study
Editors’ note: A content of this abstract was published in BLOOD 2013; 122: Abstract #2400. See link: http://bloodjournal.hematologylibrary.org/content/122/21/2400.abstract?sid=5c45f13c-ae41-421c-9f02-18ae75fc1977 (Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - July 1, 2014 Category: Hematology Authors: Guillaume Richard-Carpentier, Normand Blais, Benjamin Rioux-Massé Tags: Abstracts Source Type: research
