Patient Blood Management Bundles to facilitate implementation
Over 30% of the world's population are anaemic with serious economic consequences including reduced work capacity and other obstacles to national welfare and development. Red blood cell (RBC) transfusion is the mainstay to correct anaemia, but it is also one of the top five overused procedures. Patient Blood Management (PBM) is a proactive, patient-centred and multidisciplinary approach to manage anaemia, optimise haemostasis, minimise iatrogenic blood loss, and harness tolerance to anaemia. Although the World Health Organisation has endorsed PBM in 2010, many hospitals still seek guidance with the implementation of PBM in...
Source: Transfusion Medicine Reviews - May 27, 2016 Category: Hematology Authors: Patrick Meybohm, Toby Richards, James Isbister, Axel Hofmann, Aryeh Shander, Lawrence Tim Goodnough, Manuel Muñoz, Hans Gombotz, Christian Friedrich Weber, Suma Choorapoikayil, Donat Spahn, Kai Zacharowski Source Type: research
Hemolytic Disease of the Fetus and Newborn: Modern Practice and Future Investigations
Red blood cell (RBC) sensitization occurs in some women in response to exposure to paternally derived RBC antigens during pregnancy or to nonself antigens on transfused RBCs during their lifetime. Once sensitized, future pregnancies may be at risk for hemolytic disease of the fetus and newborn. Although great strides have been made over the past few decades in terms of identifying blood group antigens and in predicting fetal anemia through the use of noninvasive monitoring, many questions remain in terms of understanding RBC alloimmunization risk factors, preventative therapies, and treatment strategies. (Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - May 26, 2016 Category: Hematology Authors: Jeanne E. Hendrickson, Meghan Delaney Source Type: research
Neonatal Platelet Transfusions and Future Areas of Research
Thrombocytopenia affects approximately one fourth of neonates admitted to neonatal intensive care units, and prophylactic platelet transfusions are commonly administered to reduce bleeding risk. However, there are few evidence-based guidelines to inform clinicians' decision-making process. Developmental differences in hemostasis and differences in underlying disease processes make it difficult to apply platelet transfusion practices from other patient populations to neonates. Thrombocytopenia is a risk factor for common preterm complications such as intraventricular hemorrhage; however, a causal link has not been establish...
Source: Transfusion Medicine Reviews - May 26, 2016 Category: Hematology Authors: Martha Sola-Visner, Rachel S. Bercovitz Source Type: research
Massive Transfusion in Children
Massive transfusions occur frequently in pediatric trauma patients, among some children undergoing surgery, or in children with critical illness. Over the last years, many authors have studied different aspects of massive transfusions, starting with an operative definition. Some information is available on transfusion strategies and adjunctive treatments. Areas that require additional investigation include: studies to assess which children benefit from transfusion protocols based on fixed ratios of blood components vs transfusion strategies based on biophysical parameters and laboratory tests; whether goal-directed therapi...
Source: Transfusion Medicine Reviews - May 26, 2016 Category: Hematology Authors: Oliver Karam, Marisa Tucci Source Type: research
Hemolytic Disease of the Fetus and Newborn: Modern Practice and Future Investigations
Red blood cell (RBC) sensitization occurs in some women in response to exposure to paternally derived RBC antigens during pregnancy or to non-self antigens on transfused RBCs during their lifetime. Once sensitized, future pregnancies may be at risk for hemolytic disease of the fetus and newborn (HDFN). Although great strides have been made over the past few decades in terms of identifying blood group antigens and in predicting fetal anemia through the use of non-invasive monitoring, many questions remain in terms of understanding RBC alloimmunization risk factors, preventative therapies, and treatment strategies. (Source: ...
Source: Transfusion Medicine Reviews - May 26, 2016 Category: Hematology Authors: Jeanne E. Hendrickson, Meghan Delaney Source Type: research
Massive Transfusion in Children
Massive transfusions occur frequently in pediatric trauma patients, among some children undergoing surgery, or in children with critical illness. Over the last years, many authors have studied different aspects of massive transfusions, starting with an operative definition. Some information is available on transfusion strategies and adjunctive treatments. Areas that require additional investigation include: studies to assess which children benefit from transfusion protocols based on fixed ratios of blood components versus transfusion strategies based on biophysical parameters and laboratory tests; whether goal-directed the...
Source: Transfusion Medicine Reviews - May 26, 2016 Category: Hematology Authors: Oliver Karam, Marisa Tucci Source Type: research
Neonatal Platelet Transfusions and Future Areas of Research
Thrombocytopenia affects approximately one-fourth of neonates admitted to neonatal intensive care units, and prophylactic platelet transfusions are commonly administered to reduce bleeding risk. However, there are few evidence-based guidelines to inform clinicians' decision-making process. Developmental differences in hemostasis and differences in underlying disease processes make it difficult to apply platelet transfusion practices from other patient populations to neonates. Thrombocytopenia is a risk factor for common preterm complications such as intraventricular hemorrhage, however a causal link has not been establishe...
Source: Transfusion Medicine Reviews - May 26, 2016 Category: Hematology Authors: Martha Sola-Visner, Rachel S. Bercovitz Source Type: research
Journal Club
(Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - May 23, 2016 Category: Hematology Authors: Simon Stanworth, Richard Haspel, Jeannie Callum Source Type: research
Autologous Blood Transfusion in Sports: Emerging Biomarkers
Despite being prohibited by the World Anti-Doping Agency, blood doping through erythropoietin injection or blood transfusion is frequently used by athletes to increase oxygen delivery to muscles and enhance performance. In contrast with allogeneic blood transfusion and erythropoietic stimulants, there is presently no direct method of detection for autologous blood transfusion (ABT) doping. Blood reinfusion is currently monitored with individual follow-up of hematological variables via the athlete biological passport, which requires further improvement. (Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - May 20, 2016 Category: Hematology Authors: Olivier Salamin, Sara De Angelis, Jean-Daniel Tissot, Martial Saugy, Nicolas Leuenberger Tags: Original Article Source Type: research
Autologous Blood Transfusion in Sports: Emerging Biomarkers
Despite being prohibited by the World Anti-Doping Agency, blood doping through erythropoietin (EPO) injection or blood transfusion is frequently used by athletes to increase oxygen delivery to muscles and enhance performance. In contrast with allogeneic blood transfusion and erythropoietic stimulants, there is presently no direct method of detection for autologous blood transfusion (ABT) doping. Blood reinfusion is currently monitored with individual follow-up of hematological variables via the Athlete Biological Passport, which requires further improvement. (Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - May 20, 2016 Category: Hematology Authors: Olivier Salamin, Sara De Angelis, Jean-Daniel Tissot, Martial Saugy, Nicolas Leuenberger Source Type: research
Transfusion-Transmitted Babesia microti
Because testing of donors for Babesia microti has become available, it is important to determine the kinds of patients who should receive B microti –tested blood. We searched PubMed, AABB abstracts, and FDA Web site to identify all cases of transfusion-transmitted babesiosis (TTB). Cases were analyzed for underlying medical condition, age, presence of spleen, and reason for transfusion in relation to 5 classes of recipient outcome severity. S ixty-seven reports included 256 transfusion cases where donor tested positive for B microti, 165 of which resulted in TTB. (Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - April 27, 2016 Category: Hematology Authors: Deanna C. Fang, Jeffrey McCullough Tags: Original Article Source Type: research
Transfusion-Transmitted Babesia microti
Because testing of donors for Babesia microti has become available, it is important to determine the kinds of patients who should receive B microti–tested blood. We searched PubMed, AABB abstracts, and FDA Web site to identify all cases of transfusion-transmitted babesiosis (TTB). Cases were analyzed for underlying medical condition, age, presence of spleen, and reason for transfusion in relation to 5 classes of recipient outcome severity. Sixty-seven reports included 256 transfusion cases where donor tested positive for B microti, 165 of which resulted in TTB. (Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - April 27, 2016 Category: Hematology Authors: Deanna C. Fang, Jeffrey McCullough Source Type: research
Transfusion Transmitted Babesia microti
Since testing of donors for Babesia microti has become available, it is important to determine the kinds of patients who should receive Babesia microti-tested blood. We searched PubMed, AABB abstracts, and FDA web site to identify all cases of transfusion-transmitted Babesia microti (TTB). Cases were analyzed for underlying medical condition, age, presence of spleen, and reason for transfusion in relation to five classes of recipient outcome severity. Sixty-seven reports included 256 transfusion cases where donor tested positive for Babesia microti, 165 of which resulted in transfusion-transmitted babesiosis (TTB). (Source...
Source: Transfusion Medicine Reviews - April 27, 2016 Category: Hematology Authors: Deanna C. Fang, Jeffrey McCullough Source Type: research
Acquired Factor XIII Inhibitor in Hospitalized and Perioperative Patients: A Systematic Review of Case Reports and Case Series
Factor XIII (FXIII) cross-links fibrin monomers to support clot stabilization and wound healing. Acquired FXIII deficiency is caused by autoantibodies that inhibit FXIII and can result in bleeding despite normal routine coagulation test results. Given the rarity of this disease, large clinical studies are not feasible. We therefore conducted a systematic review of case reports and case series of acquired FXIII inhibitor to evaluate potential management and treatment strategies for acquired FXIII inhibitor in hospitalized and/or perioperative patients. (Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - April 20, 2016 Category: Hematology Authors: Kira J. Tone, Tyler E. James, Dean A. Fergusson, Alan Tinmouth, Jason Tay, Marc T. Avey, Shaun Kilty, Manoj M. Lalu Tags: Original Article Source Type: research
