RHD genotyping for prenatal patients with a serologic weak D phenotype
Introduction: In 2014, the College of American Pathologists (CAP) Transfusion Medicine Resource Committee (TMRC) recommended genotyping of prenatal patients with a discordant and/or serologic weak D phenotype. Patients found to be weak D types 1, 2, or 3 are treated as D+, avoiding Rh immune globulin. This is already the policy for CBS prenatal programs in western Canada. In Ontario and Nova Scotia, samples are being sent to CBS from selected hospitals for D genotyping. We compared results from Ontario and Nova Scotia with those obtained in Alberta and anticipated by TMRC. (Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - September 22, 2015 Category: Hematology Authors: M. Goldman, J. Coté, J. Hannon, G. Clarke, G. Ochoa-Garay, C. Pambrun Source Type: research
Small molecule ice recrystallization inhibitors enable freezing of human red blood cells with reduced glycerol concentrations
Background: In North America, red blood cells (RBCs) are cryopreserved in a clinical setting using high glycerol concentrations (40% wt/vol) with slow cooling rates (1°C/min) before storage at −80°C, whereas European protocols use reduced glycerol concentrations with rapid freezing rates. After thawing and before transfusion, glycerol must be removed to avoid intravascular hemolysis. This is a time-consuming process requiring specialized equipment. Consequently, improvements in the RBC cryopreservation process are urgently required. (Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - September 22, 2015 Category: Hematology Authors: Jason P. Acker, Chantelle J. Capicciotti, Jayme D.R. Kurach, Tracey R. Turner, Ross S. Mancini, Robert N. Ben Source Type: research
Are blood transfusion reactions underrecognized or underreported?
Introduction: Blood transfusions have become an important adjunct in health care. Nonetheless, there are risks associated with transfusions. Identifying and reporting blood transfusion reactions are fundamental aspects of patient safety. However, transfusion reactions are frequently underrecognized and underreported. (Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - September 22, 2015 Category: Hematology Authors: WRHA Blood Conservation Service Nursing Team Source Type: research
Journal Club
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Source: Transfusion Medicine Reviews - September 22, 2015 Category: Hematology Authors: Richard Haspel, Simon Stanworth, Jeannie Callum Source Type: research
Masthead
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Source: Transfusion Medicine Reviews - September 22, 2015 Category: Hematology Source Type: research
Title Page
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Source: Transfusion Medicine Reviews - September 22, 2015 Category: Hematology Source Type: research
Editorial Board
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Source: Transfusion Medicine Reviews - September 22, 2015 Category: Hematology Source Type: research
Table of Contents
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Source: Transfusion Medicine Reviews - September 22, 2015 Category: Hematology Source Type: research
Aims and Scope
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Source: Transfusion Medicine Reviews - September 22, 2015 Category: Hematology Source Type: research
Red blood cell transfusion in patients with traumatic brain injury: a systematic review and meta-analysis
Our objectives were to evaluate the frequency of red blood cells (RBC) transfusion in patients with traumatic brain injury (TBI) as well as potential determinants and outcomes associated with RBC transfusion in this population. We conducted a systematic review of cohort studies and randomized trials of patients with TBI. We searched Medline, Embase, the Cochrane Library and BIOSIS databases from their inception up to April 2015. We selected studies of adult patients with acute TBI reporting data on RBC transfusions. (Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - August 27, 2015 Category: Hematology Authors: Amélie Boutin, Michaël Chassé, Michèle Shemilt, François Lauzier, Lynne Moore, Ryan Zarychanski, Donald Griesdale, Philippe Desjardins, Jacques Lacroix, Dean Fergusson, Alexis F. Turgeon Source Type: research
Platelet MicroRNAs: An Overview
MicroRNAs are short ~ 22 nucleotide non-coding RNA that have been found to influence the expression of many genes and cellular processes by either repressing translation or degrading mRNA transcripts. Platelet miRNA expression has been shown to be perturbed during ex vivo storage of platelets and in platelet associated disorders. While bioinformatics-based miRNA target predictions have been established, direct experimental validation of the role of miRNAs in platelet biology has been rather slow. (Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - August 10, 2015 Category: Hematology Authors: Neetu Dahiya, Tewarit Sarachana, Long Vu, Kevin G. Becker, William H. Wood, Yongqing Zhang, Chintamani D. Atreya Source Type: research
Coagulation factor concentrates fail to restore alterations in fibrin formation caused by rivaroxaban or dabigatran in studies with flowing blood from treated healthy volunteers
We evaluated the hemostatic alterations in blood from healthy individuals treated for 5 days with direct oral anticoagulants (DOACs) rivaroxaban (20 mg/day) or dabigatran (150 mg/12 h) in a single blind clinical trial with crossover assignment (NCT01478282). We assessed the potential of prothrombin complex concentrates (PCCs), activated PCCs or rFVIIa, when added ex vivo, to reverse the alterations caused by these DOACs. Blood was drawn at Cmax after the last dose of each DOAC and modifications in coagulation biomarkers evaluated using a series of tests performed under steady conditions including: routine coagulation, thro...
Source: Transfusion Medicine Reviews - August 8, 2015 Category: Hematology Authors: Eduardo Arellano-Rodrigo, Irene Lopez-Vilchez, Ana M. Galan, Patricia Molina, Joan Carles Reverter, Xavier Carné, Jaume Villalta, Dolors Tassies, Miguel Lozano, Maribel Díaz-Ricart, Gines Escolar Source Type: research
Prophylactic use of tranexamic acid for postpartum bleeding outcomes: a systematic review and meta-analysis of randomized controlled trials
Despite multimodal approaches to treatment, postpartum hemorrhage (PPH) is a life threatening condition whose incidence continues to rise. In developing areas, such as sub-Saharan Africa, PPH is the leading cause of maternal mortality. Tranexamic acid (TXA) is a possible prophylactic treatment for the prevention of PPH. We performed a systematic review and meta-analysis of randomized trials comparing prophylactic TXA versus placebo or no treatment in term parturients to quantify the effects of prophylactic TXA administration on peripartum bleeding outcomes. (Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - July 16, 2015 Category: Hematology Authors: Asim Alam, Stephen Choi Source Type: research
Adoptive immunotherapies after allogeneic hematopoietic stem cell transplantation in patients with hematologic malignancies
Hematopoietic stem cell transplantation (HSCT) is the only curative therapy for patients with chemotherapy-resistant hematological malignancies which are usually fatal in absence of treatment. HSCT is associated with significant early and late morbidity and mortality. Graft-versus-host disease, infections and relapse are the most important causes of mortality after HSCT. Until now, these complications have been managed mainly with pharmacological drugs but in some situations this approach clearly shows its limit. (Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - July 9, 2015 Category: Hematology Authors: Yu Xiong, Danièle Bensoussan, Véronique Decot Source Type: research
Long-Acting Anticoagulant Rodenticide (Superwarfarin) Poisoning: A Review of Its Historical Development, Epidemiology, and Clinical Management
This article intends to provide the reader a comprehensive understanding of LAAR poisoning. An exhaustive literature search of PubMed, Science Direct, US National Library of Medicine Toxicology Data Network, and Google Scholar yielded 174 reported cases of LAAR poisoning from which clinical data were extracted and reviewed. (Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - July 6, 2015 Category: Hematology Authors: Nathan King, Minh-Ha Tran Source Type: research
