Guidance on Platelet Transfusion for Patients with Hypoproliferative Thrombocytopenia
Patients with hypoproliferative thrombocytopenia are at an increased risk of hemorrhage and alloimmunization to platelets. Updated guidance for optimizing platelet transfusion therapy is needed as data from recent pivotal trials have the potential to change practice. This guideline, developed by a large international panel using a systematic search strategy and standardized methods to develop recommendations, incorporates recent trials not available when previous guidelines were developed. We found that prophylactic platelet transfusion for platelet counts less than or equal to 10 x 109/L is the optimal approach to decreas...
Source: Transfusion Medicine Reviews - November 26, 2014 Category: Hematology Authors: Susan Nahirniak, Sherrill J. Slichter, Susano Tanael, Paolo Rebulla, Katerina Pavenski, Ralph Vassallo, Mark Fung, Rene Duquesnoy, Chee-Loong Saw, Simon Stanworth, Alan Tinmouth, Heather Hume, Arjuna Ponnampalam, Catherine Moltzan, Brian Berry, Nadine She Source Type: research
Platelet derivatives in regenerative medicine: an update
Prior preclinical and clinical studies support the use of platelet-derived products for the treatment of soft and hard tissue lesions. These regenerative effects are controlled by autocrine and paracrine biomolecules including growth factors and cytokines contained in platelet alpha granules. Each growth factor is involved in a phase of the healing process, such as inflammation, collagen synthesis, tissue granulation and angiogenesis collectively promoting tissue restitution. Platelet derivatives have been prepared as platelet rich plasma, platelet gel, platelet rich fibrin, and platelet eye drops. (Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - November 18, 2014 Category: Hematology Authors: Maria Rosaria De Pascale, Linda Sommese, Amelia Casamassimi, Claudio Napoli Source Type: research
The impact of electronic decision support on transfusion practice: a systematic review
The objective of this systematic review was to assess the effects of electronic DSS on blood product ordering practices. Eligible studies were identified from searches of MEDLINE, Embase, CINAHL, The Cochrane Library, PubMed and the Transfusion Evidence Library from January 2000 to April 2014. Of these, 23 articles were eligible, resulting in the inclusion of 20 independent studies in this systematic review. (Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - November 3, 2014 Category: Hematology Authors: Stephen P. Hibbs, Nathan D. Nielsen, Susan Brunskill, Carolyn Doree, Mark H. Yazer, Richard M. Kaufman, Michael F. Murphy Source Type: research
The Effect of Holding Times of Whole Blood and Its Components During Processing on In Vitro and In Vivo Quality
Whole blood is not usually collected close to the processing site, which results in a holding time between collection and processing. In some countries, the holding time is limited to 8 hours, after which the units are cooled, rendering them useless for platelet preparation. Other countries allow a 24-hour (“overnight”) ambient hold to allow platelet preparation. The impact of this holding time on subsequent blood components will be reviewed in this article. In addition, there are various “in-process” holding times that further prolong the time before the final blood component is ready. (Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - October 30, 2014 Category: Hematology Authors: Pieter F. van der Meer, Dirk de Korte Source Type: research
The Effect of Holding Times Whole Blood and its Components During Processing on and Quality
Whole blood is not usually collected close to the processing site, which results in a holding time between collection and processing. In some countries, the holding time is limited to 8 h after which the units are cooled, rendering them useless for platelet preparation. Other countries allow a 24 hour (“overnight”) ambient hold to allow platelet preparation. The impact of this e holding time on subsequent blood components will be reviewed in this paper. In addition, there are various “in-process” holding times that further prolong the time before the final blood component is ready. (Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - October 30, 2014 Category: Hematology Authors: Pieter F. van der Meer, Dirk de Korte Source Type: research
National Institutes of Health State of the Science Symposium in Therapeutic Apheresis: Scientific Opportunities in Extracorporeal Photopheresis
The clinical use of extracorporeal photopheresis (ECP) for accepted indications such as graft versus host disease, transplant rejection, and cutaneous T- cell lymphoma continues to increase. Expanded applications for ECP, such as the treatment of select autoimmune diseases, are being explored. ECP’s capacity to both immunotolerize in the autoreactive setting, while immunizing against a lymphoma is unusual and suggestive of a unique mechanism. It is likely that ECP’s induction of dendritic cells is key to its efficacy in both of these settings, but exactly how ECP impacts other immune components and their interactions i...
Source: Transfusion Medicine Reviews - October 14, 2014 Category: Hematology Authors: Nora Ratcliffe, Nancy M. Dunbar, Jill Adamski, Daniel Couriel, Richard Edelson, Carrie L. Kitko, John Levine, Shanna Morgan, Jennifer Schneiderman, Steve Sloan, Yanyun Wu, Zbigniew M. Szczepiorkowski, Laura Cooling, for the American Society for Apheresis Source Type: research
Masthead
(Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - October 1, 2014 Category: Hematology Source Type: research
Title page
(Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - October 1, 2014 Category: Hematology Source Type: research
Editorial Board
(Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - October 1, 2014 Category: Hematology Source Type: research
Contents
(Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - October 1, 2014 Category: Hematology Source Type: research
Aims and Scope
(Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - October 1, 2014 Category: Hematology Source Type: research
Postdonation Information and Blood Component Retrievals: Realigning Blood Center and Hospital Actions Based on Risk Assessment
Blood centers often receive information from individuals after blood donation that should have resulted in their deferral and may attempt to retrieve distributed blood components that did not meet all quality standards and regulations. Typically, the information is discovered or reported only after the components from the donation have been transfused. Blood centers may notify the transfusion service and provide a statement of the potential risk, if any, associated with the blood components, but the transfusion service must decide if further investigation, notification of the transfusing physician, or counseling of the pat...
Source: Transfusion Medicine Reviews - September 26, 2014 Category: Hematology Authors: Anne F. Eder, Mindy Goldman Source Type: research
The use of rapid diagnostic tests for transfusion infectious screening in Africa: a literature review
Infectious risk associated with blood transfusion remains a major public health challenge in Africa, where prevalence rates of the major transfusion transmissible infections [i.e. Hepatitis B, Hepatitis C, HIV and Syphilis] are amongst the highest in the world. Resource-limited blood services often operate with minimal pre-donation screening safeguards, prompting exclusive reliance on laboratory testing to mitigate infectious risk. Transfusion screening with rapid diagnostic tests (RDTs) has been adopted in areas that lack the capacity to support the routine use of more sophisticated technologies. (Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - September 26, 2014 Category: Hematology Authors: C.R. Pruett, M. Vermeulen, P. Zacharias, C. Ingram, C. Tayou Tagny, E.M. Bloch Source Type: research
Review of In Vivo Studies of Dimethyl Sulfoxide Cryopreserved Platelets
A literature review was conducted to assess the efficacy and safety of dimethyl sulfoxide (DMSO) cryopreserved platelets for potential military use. In vivo DMSO cryopreserved platelet studies published between 1972 and June of 2013 were reviewed. Assessed were the methods of cryopreservation, posttransfusion platelet responses, prevention or control of bleeding, and adverse events. Using the Department of Defense's preferred 6% DMSO cryopreservation method with centrifugation to remove the DMSO plasma before freezing at −65°C and no postthaw wash, mean radiolabeled platelet recoveries in 32 normal subjects were 33% ± ...
Source: Transfusion Medicine Reviews - September 18, 2014 Category: Hematology Authors: Sherrill J. Slichter, Melinh Jones, Janet Ransom, Irena Gettinger, Mary Kay Jones, Todd Christoffel, Esther Pellham, S. Lawrence Bailey, Jill Corson, Doug Bolgiano Source Type: research
Journal Club
(Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - September 10, 2014 Category: Hematology Authors: Richard Haspel, Simon Stanworth, Jeannie Callum Source Type: research
