The Kidd (JK) Blood Group System
The Kidd blood group system was discovered in 1951 and is composed of two antithetical antigens, Jka and Jkb, along with a third high incidence antigen, Jk3. The Jk3 antigen is expressed in all individuals except those with the rare Kidd-null phenotype. Four Kidd phenotypes are therefore possible: Jk(a+b-), Jk(a-b+), Jk(a+b+), and Jk(a-b-). The glycoprotein carrying the Kidd antigens is a 43 kDa, 389 amino acid protein with 10 membrane-spanning domains which functions as a urea transporter on endothelial cells of the renal vasa recta as well as erythrocytes. (Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - November 7, 2016 Category: Hematology Authors: Shaun Lawicki, Randal B. Covin, Amy A. Powers Source Type: research
The impact of emerging infectious diseases on Chinese blood safety
Emerging infectious diseases (EIDs) have always been one of the major threats to public health. Although the implementation of mandatory testing on four classical transfusion-transmitted infectious (TTIs), including human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV) and syphilis, has demonstrated its effectiveness to reduce the transfusion risks of these pathogens, the potential threats of various EID agents and their constantly evolving variants to blood safety in China are yet to be known. (Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - November 3, 2016 Category: Hematology Authors: Miao He, Jingxing Wang, Limin Chen, Jing Liu, Peibin Zeng Source Type: research
Journal Club
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Source: Transfusion Medicine Reviews - October 19, 2016 Category: Hematology Authors: Richard Haspel, Simon Stanworth, Jeannie Callum Source Type: research
Masthead
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Source: Transfusion Medicine Reviews - September 13, 2016 Category: Hematology Source Type: research
Title Page
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Source: Transfusion Medicine Reviews - September 13, 2016 Category: Hematology Source Type: research
Editorial Board
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Source: Transfusion Medicine Reviews - September 13, 2016 Category: Hematology Source Type: research
Contents
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Source: Transfusion Medicine Reviews - September 13, 2016 Category: Hematology Source Type: research
Aims and Scope
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Source: Transfusion Medicine Reviews - September 13, 2016 Category: Hematology Source Type: research
Special Issue Title Page
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Source: Transfusion Medicine Reviews - September 13, 2016 Category: Hematology Source Type: research
Practical Use of Thromboelastometry in the Management of Perioperative Coagulopathy and Bleeding
Achieving hemostasis after complex cardiovascular and transplant surgeries is one of the greatest challenges anesthesiologists face. Preoperative coagulation disturbances due to underlying disease or antithrombotic therapy are common, and they are worsened by intraoperative blood loss and fluid replacement. The coagulation reactions in vivo are incredibly complex interactions among blood cells, proteins and vasculature, standing in sharp contrast to rather simple treatment options including transfusion of platelets, plasma, and cryoprecipitate. (Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - August 26, 2016 Category: Hematology Authors: Brittney Williams, John McNeil, Andrew Crabbe, Kenichi A. Tanaka Source Type: research
Erythrocytes as carriers for drug delivery in blood transfusion and beyond
Red blood cells (RBCs) are innate carriers that can also be engineered to improve the pharmacokinetics and pharmacodynamics of many drugs, particularly bio-therapeutics. Successful loading of drugs, both internally and on the external surface of RBCs, has been demonstrated for many drugs including anti-inflammatory, anti-microbial, and anti-thrombotic agents. Methods for internal loading of drugs within RBCs are now entering clinical use. While internal loading can result in membrane disruption that may compromise biocompatibility, surface loading using either affinity or chemical ligands offers a diverse set of approaches...
Source: Transfusion Medicine Reviews - August 17, 2016 Category: Hematology Authors: Carlos H. Villa, Douglas B. Cines, Don L. Siegel, Vladimir Muzykantov Source Type: research
Zika Virus and the Blood Supply: What do we know?
Zika virus (ZIKV), a mosquito borne flavivirus and emerging infectious disease, is the focus of an international public health emergency following its rapid spread through the Americas and the Caribbean. Although the majority of ZIKV infections are subclinical or characterized by mild febrile illness, ZIKV has been implicated in severe complications, most notably microcephaly in babies born to incident infected mothers during pregnancy. As yet, the extent to which ZIKV is transfusion transmissible remains undefined. (Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - August 8, 2016 Category: Hematology Authors: Alexandra Jimenez, Beth H. Shaz, Evan M. Bloch Source Type: research
Pediatric Therapeutic Apheresis: A Critical Appraisal of Evidence
Apheresis technology has progressed significantly over the last 50 –60years from a predominately blood donation based procedure to one that now includes a variety of therapeutic modalities. The last 25years also has seen an increase in the number of diseases treated by therapeutic apheresis (TA) modalities. Because of ethical considerations, therapeutic modalitie s are often vetted first in adult populations before establishing utility in pediatric patients. TA is no different. The majority of published studies involve adult patients. (Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - August 7, 2016 Category: Hematology Authors: Erin K. Meyer, Edward C.C. Wong Source Type: research
Pediatric and Neonatal Transfusion Medicine: A Roadmap for Research
Pediatric Transfusion Medicine (PTM) has been evolving as a subspecialty over the past 30 years. Those individuals knowledgeable about PTM recognize the significant physiological adaptation intrinsic to the transition from fetus to neonate to childhood and adolescence. They also recognize the effect of congenital abnormalities, unique disease states and unusual presentations of common disorders. Considerations include the maternal-fetal unit, ever changing body weight, blood and plasma volumes, developing hepatic, renal, hematologic and immune systems and the effect of environmental and drug-related toxicants on the develo...
Source: Transfusion Medicine Reviews - August 7, 2016 Category: Hematology Authors: Cassandra D. Josephson, Naomi L.C. Luban Tags: Guest Editorial Source Type: research
Challenges with Navigating the Precarious Hemostatic Balance during Extracorporeal Life Support: Implications for Coagulation and Transfusion Management
For the past four decades, extracorporeal life support (ECLS) has been used to treat critically ill adult and pediatric patients with cardiac and/or respiratory failure, and there are increasingly numbers of centers worldwide performing ECLS for numerous indications. Despite the progress with advancing the technology, hemorrhagic and thrombotic complications are frequently reported and associated with worse outcomes, but the exact cause is often elusive or multifactorial. As a result of the interaction between blood and an artificial circuit, anticoagulation is necessary and there is resultant activation of coagulation, fi...
Source: Transfusion Medicine Reviews - August 3, 2016 Category: Hematology Authors: Jennifer Andrews, Anne M. Winkler Source Type: research
