Understanding intravenous iron ordering practices for inpatients and outpatients at a large academic institution
Introduction: Iron deficiency anemia (IDA) affects billions of individuals worldwide and can result in decreased quality of life, epithelial tissue injury, fatigue and decreased cognitive function. Treatment includes identifying etiology and iron repletion. Intravenous iron is considered in patients refractory to oral iron supplementation. Though randomized control trials and guideline are beginning to emerge for certain populations, there remains of paucity of evidence around IV iron use in everyday practice. (Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - June 30, 2016 Category: Hematology Authors: Michelle P. Zeller, Rebecca Barty, Yang Liu, Grace Wang, Natalie Ramsay, Donald M. Arnold, Alfonso Iorio, Nancy M. Heddle Source Type: research
When is a Positive Truly So? Defining a New Cut-Off in a Precautionary Approach to D Typing in Child-Bearing Age Female Individuals
Purpose: RHD typing in child bearing age females (CBAF) dictates who warrants Rh immunoprophylaxis and restriction to D-cellular products. “D+” has been defined as ≥2+ reactivity (irrespective of test modality) and assumes wildtype configuration/D tolerance. However, inter-reagent discrepancies may suggest sensitization-vulnerable variants. We sought to determine our rate of modality-related D-discrepancies, as defined by ≥2+ g el results despite weak or negative tube reads, and their correlative genotypic/clinical meaning. (Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - June 30, 2016 Category: Hematology Authors: Lisa Richards, Irene Skinner, Allan Lupish, Grant Johnson, Sally Balmer, Lani Lieberman, Yulia Lin, Jeannie Callum, Jacob Pendergrast, Christine Cserti-Gazdewich Source Type: research
Masthead
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Source: Transfusion Medicine Reviews - June 30, 2016 Category: Hematology Source Type: research
Title Page
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Source: Transfusion Medicine Reviews - June 30, 2016 Category: Hematology Source Type: research
Editorial Board
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Source: Transfusion Medicine Reviews - June 30, 2016 Category: Hematology Source Type: research
Contents
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Source: Transfusion Medicine Reviews - June 30, 2016 Category: Hematology Source Type: research
Aims and Scope
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Source: Transfusion Medicine Reviews - June 30, 2016 Category: Hematology Source Type: research
Is Autologous Salvaged Blood a Viable Option for Patient Blood Management in Oncologic Surgery?
Oncologic surgery is sometimes associated with substantial blood loss, and principles of patient blood management can be applied in the perioperative care of these patients. Although autologous salvaged blood is an option for perioperative blood conservation, it is often not used in oncologic surgery over concern of reinfusing tumor cells and thereby causing tumor dissemination. We reviewed the literature regarding safety and effectiveness of salvaged blood in oncologic surgery. Salvaged blood seems to be comparable to allogeneic blood in terms of safety. (Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - June 20, 2016 Category: Hematology Authors: Aye Sandar Zaw, Shashidhar Bangalore Kantharajanna, Naresh Kumar Source Type: research
Clinical and Laboratory Consequences of Platelet Transfusion in Shiga Toxin –Mediated Hemolytic Uremic Syndrome
Recent studies suggest that platelet transfusions are harmful in patients with thrombotic thrombocytopenic purpura, an entity of thrombotic microangiopathies. As the typical or Shiga toxin –producing Escherichia coli–induced hemolytic uremic syndrome (STEC-HUS) is also classified as thrombotic microangiopathy, we complement these data with an analysis of 250 patients from the German O104:H4 STEC-HUS outbreak. The effect of platelet transfusion in 44 patients who received platelet transfusions vs 206 control patients was investigated. (Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - June 20, 2016 Category: Hematology Authors: Jan Beneke, Aleksej Sartison, Jan T. Kielstein, Hermann Haller, Martin Nitschke, Ulrich Kunzendorf, Sebastian Loos, Markus J. Kemper, Rolf A.K. Stahl, Jan Menne, for the German 2011 STEC-HUS outbreak study group Source Type: research
Is Autologous Salvaged Blood a Viable Option For Patient Blood Management in Oncologic Surgery?
Oncologic surgery is sometimes associated with substantial blood loss and principles of patient blood management can be applied in the perioperative care of these patients. Although autologous salvaged blood is an option for perioperative blood conservation, it is often not used in oncologic surgery over concern of reinfusing tumor cells and thereby causing tumor dissemination. We reviewed the literature regarding safety and effectiveness of salvaged blood in oncologic surgery. Salvaged blood appears to be comparable to allogeneic blood in terms of safety. (Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - June 20, 2016 Category: Hematology Authors: Aye Sandar Zaw, Shashidhar Bangalore Kantharajanna, Naresh Kumar Source Type: research
Clincial and laboratory consequences of platelet transfusion in Shiga toxin-mediated Hemolytic Uremic Syndrome
Recent studies suggest that platelet transfusions are harmful in patients with thrombotic thrombocytopenic purpura (TTP), an entity of thrombotic microangiopathies (TMA). As the typical or Shiga toxin-producing Escherichia coli induced hemolytic uremic syndrome (STEC-HUS) is also classified as TMA, we complement these data with an analysis of 250 patients from the German O104:H4 STEC-HUS outbreak. The effect of platelet transfusion in 44 patients who received platelet transfusions versus 206 control patients was investigated. (Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - June 20, 2016 Category: Hematology Authors: Jan Beneke, Aleksej Sartison, Jan T. Kielstein, Hermann Haller, Martin Nitschke, Ulrich Kunzendorf, Sebastian Loos, Markus J. Kemper, Rolf A.K. Stahl, Jan Menne, for the German 2011 STEC-HUS outbreak study group Source Type: research
Top Abstracts from the Canadian Society for Transfusion Medicine Meeting, 2016
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Source: Transfusion Medicine Reviews - June 17, 2016 Category: Hematology Source Type: research
A Review of Interfacility Blood Transportation by Ambulance to a Regional Trauma Center
There are no published data on the fate of blood components (BC) sent with patients transferred from peripheral hospital emergency departments to regional trauma centers in Canada, unlike in the US or UK. Thus, our goals were to describe the fate of such BC and to highlight possible areas for utilization improvement. (Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - June 17, 2016 Category: Hematology Authors: Vito Sanci, Yulia Lin, Jeannie Callum Source Type: research
Selection and Characterization of a DNA Aptamer Inhibiting Coagulation Factor XIa
Introduction: Coagulation factor XI (FXI) is activated either by FXIIa of the contact pathway, or by thrombin; FXIa then activates FIX. Both humans and mice deficient in FXI appear to be protected from thrombosis, with only a mild to moderate bleeding tendency. FXI is therefore an attractive target for antithrombotic agent development. DNA aptamer libraries are large arrays of DNA molecules which inhibit targets by virtue of their unique shapes. Using a combinatorial DNA library and in vitro selection, we sought to isolate an aptamer binding specifically to the active site of FXIa. (Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - June 17, 2016 Category: Hematology Authors: David A. Donkor, Varsha Bhakta, William P. Sheffield Source Type: research
