Clinical and Laboratory Consequences of Platelet Transfusion in Shiga Toxin –Mediated Hemolytic Uremic Syndrome

Recent studies suggest that platelet transfusions are harmful in patients with thrombotic thrombocytopenic purpura, an entity of thrombotic microangiopathies. As the typical or Shiga toxin –producing Escherichia coli–induced hemolytic uremic syndrome (STEC-HUS) is also classified as thrombotic microangiopathy, we complement these data with an analysis of 250 patients from the German O104:H4 STEC-HUS outbreak. The effect of platelet transfusion in 44 patients who received platelet transfusions vs 206 control patients was investigated.

Source: Transfusion Medicine Reviews - June 20, 2016 Category: Hematology Authors: Jan Beneke, Aleksej Sartison, Jan T. Kielstein, Hermann Haller, Martin Nitschke, Ulrich Kunzendorf, Sebastian Loos, Markus J. Kemper, Rolf A.K. Stahl, Jan Menne, for the German 2011 STEC-HUS outbreak study group Source Type: research