Masthead
(Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - September 20, 2017 Category: Hematology Source Type: research
Title page
(Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - September 20, 2017 Category: Hematology Source Type: research
Editorial Board
(Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - September 20, 2017 Category: Hematology Source Type: research
Table of Contents
(Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - September 20, 2017 Category: Hematology Source Type: research
Aims and Scope
(Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - September 20, 2017 Category: Hematology Source Type: research
A Study of the Pharmacokinetic Properties and the In Vivo Kinetics of Erythrocytes Loaded With Dexamethasone Sodium Phosphate in Healthy Volunteers
The objectives of this 2-phase study were to elucidate pharmacokinetics (PK), in vivo 24-hour recovery, and red blood cell (RBC) survival properties of RBC-encapsulated dexamethasone sodium phosphate (DSP) prepared using the EryDex System (EDS). The 24-hour RBC recovery and T50 survival phase studied subjects were randomized to receive autologous RBCs loaded with either 15-20 mg DSP (Group 1A) or sham saline (Group 2A). Loaded RBCs were radiolabeled with 51-Cr, and the labeled RBCs were followed over time in vivo. (Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - September 19, 2017 Category: Hematology Authors: Shodeinde A. Coker, Zbigniew M. Szczepiorkowski, Alan H. Siegel, Antonio Ferrari, Giovanni Mambrini, Ravi Anand, Richard D. Hartman, Luca Benatti, Larry J. Dumont Tags: Original Article Source Type: research
A study of the pharmacokinetic properties and the in vivo kinetics of erythrocytes loaded with dexamethasone sodium phosphate (DSP) in healthy volunteers
The objectives of this two-phase study were to elucidate pharmacokinetics (PK), in vivo 24-hour recovery and red blood cell (RBC) survival properties of RBC-encapsulated dexamethasone sodium phosphate (DSP) prepared using the EryDex System (EDS). The 24-hour RBC recovery and T50 survival phase studied subjects randomized to receive autologous RBCs loaded with either 15-20 mg DSP (Group 1A) or sham saline (Group 2A). Loaded RBCs were radiolabeled with 51-Cr and the labeled RBCs were followed over time in vivo. (Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - September 19, 2017 Category: Hematology Authors: Shodeinde A. Coker, Zbigniew M. Szczepiorkowski, Alan H. Siegel, Antonio Ferrari, Giovanni Mambrini, Ravi Anand, Richard D. Hartman, Luca Benatti, Larry J. Dumont Source Type: research
Possible utility of the basophil activation test for the analysis of mechanisms involved in allergic transfusion reactions
Allergic transfusion reactions (ATRs) are the most common adverse reactions occurring during transfusion of blood components. Although most reactions are mild and involve cutaneous manifestations, severe ATRs including life-threatening anaphylaxis may also occur. The mechanisms of ATRs are largely unknown because they have not been well studied. One of the reasons for this may be the absence of a standard assay system for investigating these processes.Basophils and/or mast cells are key effector cells in immediate-type allergic reactions. (Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - September 19, 2017 Category: Hematology Authors: Fumiya Hirayama, Kazuta Yasui, Nobuki Matsuyama, Ikue Okamura-Shiki Source Type: research
Journal Club
(Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - August 19, 2017 Category: Hematology Authors: Simon Stanworth, Rich Haspel, Jeannie Callum, Abstract Editors Source Type: research
Erratum to “Emerging Infectious Diseases and Blood Safety: Modeling the Transfusion-Transmission Risk” (Transfusion Medicine Reviews [2017] 154-164)
(See Tables 1 –3.) (Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - August 15, 2017 Category: Hematology Authors: Philip Kiely, Manoj Gambhir, Allen C Cheng, Zoe K McQuilten, Clive R Seed, Erica M Wood Tags: Erratum Source Type: research
Exploring Donor and Product Factors and Their Impact on Red Cell Post-Transfusion Outcomes
The impact of donor characteristics, red cell age, and red cell processing methods on recipient outcomes is an emerging area of research. Knowledge generated from exploring this transfusion continuum has the potential to change the way donors are selected and how donations are processed and stored with important clinical and operational impact. Recently, donor characteristics including age, gender, donation frequency, genetics, and ethnicity have been shown to affect product quality and possibly recipient outcomes. (Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - July 31, 2017 Category: Hematology Authors: Shuoyan Ning, Nancy M. Heddle, Jason P. Acker Source Type: research
Patient Blood Management in the Intensive Care Unit
Patient Blood Management underscores a fundamental shift from a product-centered approach to a patient-centric approach through timely application of evidence-based medical and surgical concepts designed to maintain hemoglobin concentration, optimize hemostasis, and minimize blood loss in an effort to improve patient outcome. In this concept, allogeneic blood transfusion is not viewed as the treatment of default for anemic patients, but one among many treatment modalities that should be weighed based on its merits – potentials risks and benefits – for the individual patient in the context of other alternatives. (Source...
Source: Transfusion Medicine Reviews - July 31, 2017 Category: Hematology Authors: Aryeh Shander, Mazyar Javidroozi, Gregg Lobel Source Type: research
The Effects of Red Blood Cell Transfusion on Tissue Oxygenation and the Microcirculation in the Intensive Care Unit: A Systematic Review
The transfusion of red blood cells (RBCs) is a common intervention in intensive care unit (ICU) patients, yet the benefits are far from clear in patients with moderate anemia (e.g.: hemoglobin (Hb) levels of 7 –10 g/dL). Determining which of these patients benefit, and how to even define benefit, from transfusion is challenging. As the intended physiological benefit underpinning RBC transfusion is to improve tissue oxygenation, several studies utilizing a wide range of assessment techniques have attempt ed to study the effects of transfusion on tissue oxygenation and microcirculatory function. (Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - July 21, 2017 Category: Hematology Authors: Nathan D. Nielsen, Ignacio Martin-Loeches, Catherine Wentowski Source Type: research
Estimating Tanzania's National Met and Unmet Blood Demand from a Survey of a Representative Sample of Hospitals
Estimating blood demand to determine collection goals challenges many low-income countries. We sampled Tanzanian hospitals to estimate national blood demand. A representative sample based on probability proportional to size (pps) sampling of 42 of 273 (15%) Tanzanian transfusing hospitals were selected. Blood bank registers, patient medical records, and blood component disposition records were reviewed prospectively from June –September 2013 to determine the number of components requested and the number and proportion issued, not issued due to non-availability, and not issued for other reasons. (Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - July 20, 2017 Category: Hematology Authors: Bakary Drammeh, Anindya De, Naomi Bock, Sonal Pathak, Abdu Juma, Regina Kutaga, Mwanakheir Mahmoud, Dunstan Haule, Senga Sembucha, Karen Chang, Efespa Nkya, Matthew Kuehnert, Anthony A. Marfin Source Type: research
Analysis of Transfusion-Related Acute Lung Injury and Possible Transfusion-Related Acute Lung Injury Reported to the French Hemovigilance Network From 2007 to 2013
Using the French Hemovigilance Network database from 2007 to 2013, we provide information on demographics, incidence, and risk factors of reported transfusion-related acute lung injury (TRALI) and possible TRALI, analyze TRALI mitigation efforts for fresh frozen plasma and platelet concentrates, and consider the impact of platelet additive solutions on TRALI incidence. We applied the Toronto consensus conference definitions for TRALI and possible TRALI. Two TRALI subgroups were considered: “antibody positive” when a donor has human leukocyte antigen (class I or II) and/or human neutrophil antigen antibodies and the rec...
Source: Transfusion Medicine Reviews - July 14, 2017 Category: Hematology Authors: Georges Andreu, Karim Boudjedir, Jean-Yves Muller, Elodie Pouchol, Yves Ozier, Guillaume Fevre, Chantal Gautreau, Jean-Fran çois Quaranta, Christian Drouet, Claire Rieux, Paul-Michel Mertes, Benoit Clavier, Monique Carlier, Imad Sandid Source Type: research
