Possible utility of the basophil activation test for the analysis of mechanisms involved in allergic transfusion reactions

Allergic transfusion reactions (ATRs) are the most common adverse reactions occurring during transfusion of blood components. Although most reactions are mild and involve cutaneous manifestations, severe ATRs including life-threatening anaphylaxis may also occur. The mechanisms of ATRs are largely unknown because they have not been well studied. One of the reasons for this may be the absence of a standard assay system for investigating these processes.Basophils and/or mast cells are key effector cells in immediate-type allergic reactions.
Source: Transfusion Medicine Reviews - Category: Hematology Authors: Source Type: research