A study of the pharmacokinetic properties and the in vivo kinetics of erythrocytes loaded with dexamethasone sodium phosphate (DSP) in healthy volunteers

The objectives of this two-phase study were to elucidate pharmacokinetics (PK), in vivo 24-hour recovery and red blood cell (RBC) survival properties of RBC-encapsulated dexamethasone sodium phosphate (DSP) prepared using the EryDex System (EDS). The 24-hour RBC recovery and T50 survival phase studied subjects randomized to receive autologous RBCs loaded with either 15-20 mg DSP (Group 1A) or sham saline (Group 2A). Loaded RBCs were radiolabeled with 51-Cr and the labeled RBCs were followed over time in vivo.

Source: Transfusion Medicine Reviews - September 19, 2017 Category: Hematology Authors: Shodeinde A. Coker, Zbigniew M. Szczepiorkowski, Alan H. Siegel, Antonio Ferrari, Giovanni Mambrini, Ravi Anand, Richard D. Hartman, Luca Benatti, Larry J. Dumont Source Type: research