Understanding intravenous iron ordering practices for inpatients and outpatients at a large academic institution
Introduction: Iron deficiency anemia (IDA) affects billions of individuals worldwide and can result in decreased quality of life, epithelial tissue injury, fatigue and decreased cognitive function. Treatment includes identifying etiology and iron repletion. Intravenous iron is considered in patients refractory to oral iron supplementation. Though randomized control trials and guideline are beginning to emerge for certain populations, there remains of paucity of evidence around IV iron use in everyday practice. (Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - June 17, 2016 Category: Hematology Authors: Michelle P. Zeller, Rebecca Barty, Yang Liu, Grace Wang, Natalie Ramsay, Donald M. Arnold, Alfonso Iorio, Nancy M. Heddle Source Type: research
When is a Positive Truly So? Defining a New Cut-Off in a Precautionary Approach to D Typing in Child-Bearing Age Female Individuals
Purpose: RHD typing in child bearing age females (CBAF) dictates who warrants Rh immunoprophylaxis and restriction to D-cellular products. “D+” has been defined as ≥2+ reactivity (irrespective of test modality) and assumes wildtype configuration/D tolerance. However, inter-reagent discrepancies may suggest sensitization-vulnerable variants. We sought to determine our rate of modality-related D-discrepancies, as defined by ≥2+ gel results despite weak or negative tube reads, and their correlative genotypic/clinical meaning. (Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - June 17, 2016 Category: Hematology Authors: Lisa Richards, Irene Skinner, Allan Lupish, Grant Johnson, Sally Balmer, Lani Lieberman, Yulia Lin, Jeannie Callum, Jacob Pendergrast, Christine Cserti-Gazdewich Source Type: research
Masthead
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Source: Transfusion Medicine Reviews - June 17, 2016 Category: Hematology Source Type: research
Title Page
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Source: Transfusion Medicine Reviews - June 17, 2016 Category: Hematology Source Type: research
Editorial Board
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Source: Transfusion Medicine Reviews - June 17, 2016 Category: Hematology Source Type: research
Contents
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Source: Transfusion Medicine Reviews - June 17, 2016 Category: Hematology Source Type: research
Aims and Scope
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Source: Transfusion Medicine Reviews - June 17, 2016 Category: Hematology Source Type: research
Gaps in research on adverse events to transfusion in pediatrics
This article focuses on four adverse consequences that have particular relevance for pediatric populations: cytomegalovirus transmission, red blood cell alloimmunization, immune altering consequences of transfusion, and necrotizing enterocolitis. (Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - June 16, 2016 Category: Hematology Authors: Ronald Jackups, William Savage Source Type: research
Complex Transfusion Issues in Pediatric Hematopoietic Stem Cell Transplantation
Advances in the fields of pediatric transfusion medicine and hematopoietic stem cell transplant have resulted in improved outcomes but also present new questions for research. The diagnostic capabilities involved in transfusion medicine have improved in recent times, now including methods for determination of red blood cell minor antigens, detection of anti –human leukocyte antigen antibodies, and noninvasive iron quantification. At the same time, transplants are being performed for more indications including nonmalignant disease and with less intense conditioning regimens that allow some recipient blood cells to persist...
Source: Transfusion Medicine Reviews - June 16, 2016 Category: Hematology Authors: Jennifer Webb, Allistair Abraham Source Type: research
Gaps in research on adverse events to transfusion in pediatrics
This article focuses on four adverse consequences that have particular relevance for pediatric populations: cytomegalovirus transmission, red blood cell alloimmunization, immune altering consequences of transfusion, and necrotizing enterocolitis. (Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - June 16, 2016 Category: Hematology Authors: Ronald Jackups, William Savage Source Type: research
Complex transfusion issues in pediatric hematopoietic stem cell transplantation
Advances in the fields of pediatric transfusion medicine and hematopoietic stem cell transplant have resulted in improved outcomes but also present new questions for research. The diagnostic capabilities involved in transfusion medicine have improved in recent times now including methods for determination of RBC minor antigen, detection of anti-HLA antibodies, and non-invasive iron quantification. At the same time transplants are being performed for more indications including non-malignant disease and with less intense conditioning regimens that allow some recipient blood cells to persist after transplant. (Source: Transfu...
Source: Transfusion Medicine Reviews - June 16, 2016 Category: Hematology Authors: Jennifer Webb, Allistair Abraham Source Type: research
Red Blood Cell Antigen Genotyping for Sickle Cell Disease, Thalassemia, and Other Transfusion Complications
Since the discovery of the ABO blood group in the early 20th century, more than 300 blood group antigens have been categorized among 35 blood group systems. The molecular basis for most blood group antigens has been determined and demonstrates tremendous genetic diversity, particularly in the ABO and Rh systems. Several blood group genotyping assays have been developed, and 1 platform has been approved by the Food and Drug Administration as a “test of record,” such that no phenotype confirmation with antisera is required. (Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - May 27, 2016 Category: Hematology Authors: Ross M. Fasano, Stella T. Chou Source Type: research
Patient Blood Management Bundles to Facilitate Implementation
More than 30% of the world's population are anemic with serious economic consequences including reduced work capacity and other obstacles to national welfare and development. Red blood cell transfusion is the mainstay to correct anemia, but it is also 1 of the top 5 overused procedures. Patient blood management (PBM) is a proactive, patient-centered, and multidisciplinary approach to manage anemia, optimize hemostasis, minimize iatrogenic blood loss, and harness tolerance to anemia. Although the World Health Organization has endorsed PBM in 2010, many hospitals still seek guidance with the implementation of PBM in clinical...
Source: Transfusion Medicine Reviews - May 27, 2016 Category: Hematology Authors: Patrick Meybohm, Toby Richards, James Isbister, Axel Hofmann, Aryeh Shander, Lawrence Tim Goodnough, Manuel Mu ñoz, Hans Gombotz, Christian Friedrich Weber, Suma Choorapoikayil, Donat R. Spahn, Kai Zacharowski Source Type: research
Red Blood Cell Antigen Genotyping for Sickle Cell Disease, Thalassemia, and Other Transfusion Complications
Since the discovery of the ABO blood group in the early 20th century, more than 300 blood group antigens have been categorized among 35 blood group systems. The molecular basis for most blood group antigens has been determined and demonstrates tremendous genetic diversity, particularly in the ABO and Rh systems. Several blood group genotyping assays have been developed, and 1 platform has been approved by the Food and Drug Administration as a “test of record,” such that no phenotype confirmation with antisera is required. (Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - May 27, 2016 Category: Hematology Authors: Ross M. Fasano, Stella T. Chou Source Type: research
Red blood cell antigen genotyping for sickle cell disease, thalassemia and other transfusion complications
Since the discovery of the ABO blood group in the early 20th century, more than 300 blood group antigens have been categorized among 35 blood group systems. The molecular basis for most blood group antigens has been determined and demonstrates tremendous genetic diversity, particularly in the ABO and Rh systems. Several blood group genotyping assays have been developed and one platform has been approved by the Food and Drug Administration (FDA) as a “test of record,” such that no phenotype confirmation with antisera is required. (Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - May 27, 2016 Category: Hematology Authors: Ross M. Fasano, Stella T. Chou Source Type: research
