New Insights Into the Treatment of Glanzmann Thrombasthenia
Glanzmann thrombasthenia (GT) is a rare inherited autosomal recessive bleeding disorder of platelet function caused by a quantitative or qualitative defect of platelet membrane glycoprotein IIb/IIIa (integrin αIIbβ3), a fibrinogen receptor required for platelet aggregation. Bleeds in GT are variable and may be severe and unpredictable. Bleeding not responsive to local and adjunctive measures, as well as surgical procedures, is treated with platelets, recombinant activated factor VII (rFVIIa), or antifibrinolytics, alone or in combination. (Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - January 29, 2016 Category: Hematology Authors: Man-Chiu Poon, Giovanni Di Minno, Roseline d’Oiron, Rainer Zotz Source Type: research
New Insights into the Treatment of Glanzmann’s Thrombasthenia
Glanzmann’s thrombasthenia (GT) is a rare inherited autosomal recessive bleeding disorder of platelet function caused by a quantitative or qualitative defect of platelet membrane glycoprotein IIb/IIIa (integrin αIIbβ3), a fibrinogen receptor required for platelet aggregation. Bleeds in GT are variable and may be severe and unpredictable. Bleeding not responsive to local and adjunctive measures, as well as surgical procedures, are treated with platelets, recombinant activated factor VII (rFVIIa) or antifibrinolytics, alone or in combination. (Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - January 29, 2016 Category: Hematology Authors: Man-Chiu Poon, Giovanni Di Minno, Roseline d’Oiron, Rainer Zotz Source Type: research
Masthead
(Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - January 1, 2016 Category: Hematology Source Type: research
Title page
(Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - January 1, 2016 Category: Hematology Source Type: research
Editorial Board
(Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - January 1, 2016 Category: Hematology Source Type: research
Contents
(Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - January 1, 2016 Category: Hematology Source Type: research
Aims and Scope
(Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - January 1, 2016 Category: Hematology Source Type: research
Why Do Blood Donors Lapse or Reduce Their Donation's Frequency?
This study seeks to compare, in a context of a voluntary and nonremunerated system, donor demographics and deterrents to blood donation among plasma/platelet donors (PPDs), regular whole blood donors (WBDs), and lapsed whole blood donors (LWBD). Among 1879 participants to a survey on motivations, time use, and blood donation, 207 WBDs (26%) and 148 PPDs (31%) said that they reduced their donation frequency over the last 5 years. Participants to this survey also included 609 LWBDs, who did not donate in the past 5 years. (Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - December 14, 2015 Category: Hematology Authors: Johanne Charbonneau, Marie-Soleil Cloutier, Élianne Carrier Tags: Original Article Source Type: research
---
(Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - December 12, 2015 Category: Hematology Authors: Sunny (Walter) Dzik, Simon Stanworth, Richard Haspel, Jeannie Callum Tags: Journal Club Source Type: research
Unraveling the Mesenchymal Stromal Cells' Paracrine Immunomodulatory Effects
In the last 10 years, the role of mesenchymal stromal cells (MSCs) in modulating inflammatory and immune responses has been characterized using both in vitro studies and in vivo models of immune disorders. Mesenchymal stromal cell immunomodulatory properties have been linked to various paracrine factors which expression varies depending on the pathologic condition to which the MSCs are exposed. These factors may directly impact key cells of the adaptive immune system, such as T cells. Indeed, coculturing MSCs with T cells in a mixed lymphocyte reaction assay inhibits T-cell proliferation through the secretion of immunomodu...
Source: Transfusion Medicine Reviews - December 1, 2015 Category: Hematology Authors: Magali J. Fontaine, Hank Shih, Richard Schäfer, Mark F. Pittenger Tags: Original Article Source Type: research
Unraveling the mesenchymal stromal cells’ paracrine immunomodulatory effects
In the last ten years the role of mesenchymal stromal cells (MSCs) in modulating inflammatory and immune responses has been characterized using both in vitro studies and in vivo models of immune disorders. MSC immunomodulatory properties have been linked to various paracrine factors which expression varies depending on the pathologic condition to which the MSCs are exposed. These factors may directly impact key cells of the adaptive immune system, such as T cells. Indeed co-culturing MSCs with T cells in a mixed lymphocyte reaction assay inhibits T cell proliferation through the secretion of immunomodulatory cytokines. (So...
Source: Transfusion Medicine Reviews - December 1, 2015 Category: Hematology Authors: Magali J. Fontaine, Hank Shih, Richard Schäfer, Mark F. Pittenger Source Type: research
Rationale and design of the Informing Fresh versus Old Red Cell Management (INFORM) Trial: An international pragmatic randomized trial
Although red blood cell transfusion is a potentially lifesaving intervention in severely anemic and acutely bleeding patients, some observational studies have suggested that prolonged red cell storage prior to transfusion is associated with harm. INFORM is a large, pragmatic, randomized controlled trial comparing the effect of the shorter-storage with longer-storage red blood cell transfusions on in-hospital mortality in hospitalized patients who require a blood transfusion. The trial is being conducted in centres in Australia, Canada, Israel and the United States, and is expected to enrol 31,497 patients. (Source: Transfu...
Source: Transfusion Medicine Reviews - November 11, 2015 Category: Hematology Authors: John W. Eikelboom, Richard J. Cook, Rebecca Barty, Yang Liu, Donald M. Arnold, Mark A. Crowther, P.J. Devereaux, Martin Ellis, Priscilla Figueroa, Alex Gallus, Jack Hirsh, Andrea Kurz, David Roxby, Daniel I. Sessler, Yehudit Sharon, Magdalena Sobieraj-Tea Source Type: research
Design and Implementation of a Competency-Based Transfusion Medicine Training Program in Canada
Transfusion Medicine training in Canada is currently undergoing a transformation from a time- and process-based curriculum to a competency-based medical education (CBME) framework. Transfusion Medicine is the first accredited postgraduate medical education training program in Canada to adopt a purely competency-based curriculum. It is serving as an example for a number of other postgraduate medical training programs undergoing a similar transition. The purpose of this review is to highlight the elements of CBME, describe its application to Transfusion Medicine training and report on the development and implementation of th...
Source: Transfusion Medicine Reviews - November 10, 2015 Category: Hematology Authors: Michelle P. Zeller, Jonathan Sherbino, Lucinda Whitman, Robert Skeate, Donald M. Arnold Source Type: research
Sirolimus for refractory autoimmune hemolytic anemia after allogeneic hematopoietic stem cell transplantation: a case report and literature review of the treatment of post-transplant autoimmune hemolytic anemia
We present a pediatric patient with refractory AIHA after umbilical cord blood transplantation (UCBT). She developed severe AIHA at 3 months after transplantation and was unresponsive to multiple treatment modalities, including corticosteroids, intravenous immunoglobulin, plasma exchange and rituximab, resulting in persistent transfusion dependency. (Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - September 25, 2015 Category: Hematology Authors: Jeong A. Park, Hyun Hee Lee, Hyun-Seop Kwon, Chung-Ryul Baik, Sae-Am Song, Jung Nye Lee Source Type: research
Production of infectious dengue virus by platelets
Introduction: Dengue virus (DENV) is the most prevalent arbovirus on the globe, annually infecting ~400 million people. Half of these are asymptomatic yet have relatively high virus titers. Therefore, it is not surprising that endemic regions have reported transfusion transmission. Once thought to be restricted to the tropics, DENV has extended outside this traditional zone due to air travel and climate change. DENV is consequently a significant risk to blood systems globally and, in Canada, is flagged as an “emerging pathogen.” (Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - September 22, 2015 Category: Hematology Authors: Edward L.G. Pryzdial, Michael R. Sutherland, Ayo Y. Simon Source Type: research
