Production of infectious dengue virus by platelets

Introduction: Dengue virus (DENV) is the most prevalent arbovirus on the globe, annually infecting ~400 million people. Half of these are asymptomatic yet have relatively high virus titers. Therefore, it is not surprising that endemic regions have reported transfusion transmission. Once thought to be restricted to the tropics, DENV has extended outside this traditional zone due to air travel and climate change. DENV is consequently a significant risk to blood systems globally and, in Canada, is flagged as an “emerging pathogen.”

Source: Transfusion Medicine Reviews - September 22, 2015 Category: Hematology Authors: Edward L.G. Pryzdial, Michael R. Sutherland, Ayo Y. Simon Source Type: research