Unraveling the Mesenchymal Stromal Cells' Paracrine Immunomodulatory Effects

In the last 10 years, the role of mesenchymal stromal cells (MSCs) in modulating inflammatory and immune responses has been characterized using both in vitro studies and in vivo models of immune disorders. Mesenchymal stromal cell immunomodulatory properties have been linked to various paracrine factors which expression varies depending on the pathologic condition to which the MSCs are exposed. These factors may directly impact key cells of the adaptive immune system, such as T cells. Indeed, coculturing MSCs with T cells in a mixed lymphocyte reaction assay inhibits T-cell proliferation through the secretion of immunomodulatory cytokines.

Source: Transfusion Medicine Reviews - December 1, 2015 Category: Hematology Authors: Magali J. Fontaine, Hank Shih, Richard Schäfer, Mark F. Pittenger Tags: Original Article Source Type: research