Masthead
(Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - January 1, 2015 Category: Hematology Source Type: research
Title Page
(Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - January 1, 2015 Category: Hematology Source Type: research
Editorial Board
(Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - January 1, 2015 Category: Hematology Source Type: research
Contents
(Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - January 1, 2015 Category: Hematology Source Type: research
Aims and Scope
(Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - January 1, 2015 Category: Hematology Source Type: research
The Fibrinolytic System—More Than Fibrinolysis?
The fibrinolytic system, known for its ability to regulate the activation of the zymogen plasminogen into active plasmin, has been primarily associated with the removal of fibrin and blood clots. Tissue-type plasminogen activator, the most well-recognized plasminogen activator, was harnessed for therapeutic benefit against thromboembolic disorders more than 30 years ago, whereas inhibition of this system has been proven effective for certain bleeding disorders. However, in recent years, new and unexpected functional roles for this system have been identified mostly in relation to the central nervous system that are both un...
Source: Transfusion Medicine Reviews - December 18, 2014 Category: Hematology Authors: Dominik F. Draxler, Robert L. Medcalf Source Type: research
The Evolving Role of the Transfusion Practitioner
Much of the recent work in transfusion practice has shifted to focus on the patient, after efforts over previous decades to ensure the quality and safety of blood products. Following the commencement of haemovigilance and transfusion practice improvement programmes, the introduction of transfusion practitioners (TP) into health care services and blood centres has continued to increase world-wide. Since this relatively new role was introduced, much work of the TP has focused on patient and staff education, adverse events, transfusion governance and monitoring of transfusion practices within organisations. (Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - December 18, 2014 Category: Hematology Authors: K. Miller, C. Akers, A.K. Davis, E.M. Wood, C. Hennessy, L. Bielby Source Type: research
Extracorporeal Membrane Oxygenation—Hemostatic Complications
The use of extracorporeal membrane oxygenation (ECMO) support for cardiac and respiratory failure has increased in recent years. Improvements in ECMO oxygenator and pump technologies have aided this increase in utilization. Additionally, reports of successful outcomes in supporting patients with respiratory failure during the 2009 H1N1 pandemic and reports of ECMO during cardiopulmonary resuscitation have led to increased uptake of ECMO. Patients requiring ECMO are a heterogenous group of critically ill patients with cardiac and respiratory failure. (Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - December 17, 2014 Category: Hematology Authors: Deirdre A. Murphy, Lisen E. Hockings, Robert K. Andrews, Cecile Aubron, Elizabeth E. Gardiner, Vincent A. Pellegrino, Amanda K. Davis Source Type: research
Hematologic Effects and Complications of Snake Envenoming
Hematologic abnormalities are the most common effects of snake envenoming globally. Venom-induced consumption coagulopathy (VICC) is the commonest and most important. Other hematologic abnormalities are an anticoagulant coagulopathy and thrombotic microangiopathy. Venom-induced consumption coagulopathy is a venom-induced activation of the clotting pathway by procoagulant toxins, resulting in clotting factor consumption and coagulopathy. The type of procoagulant toxin differs between snakes and can activate prothrombin, factor X, and factor V or consume fibrinogen. (Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - December 17, 2014 Category: Hematology Authors: Ingrid Berling, Geoffrey K. Isbister Source Type: research
Extracorporeal Membrane Oxygenation (ECMO) - Haemostatic Complications
The use of extracorporeal membrane oxygenation (ECMO) support for cardiac and respiratory failure has increased in recent years. Improvements in ECMO oxygenator and pump technologies have aided this increase in utilisation. Additionally, reports of successful outcomes in supporting patients with respiratory failure during the 2009 H1N1 pandemic, and reports of ECMO during cardiopulmonary resuscitation have led to increased uptake of ECMO. Patients requiring ECMO are a heterogenous group of critically ill patients with cardiac and respiratory failure. (Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - December 17, 2014 Category: Hematology Authors: Deirdre A. Murphy, Lisen E. Hockings, Robert K. Andrews, Cecile Aubron, Elizabeth E. Gardiner, Vincent A. Pellegrino, Amanda K. Davis Source Type: research
Red Blood Cell Storage Duration and Trauma
Numerous retrospective clinical studies suggest that transfusion of longer stored red blood cells (RBCs) is associated with an independent risk of poorer outcomes for certain groups of patients, including trauma, intensive care, and cardiac surgery patients. Large multicenter randomized controlled trials are currently underway to address the concern about RBC storage duration. However, none of these randomized controlled trials focus specifically on trauma patients with hemorrhage. Major trauma, particularly due to road accidents, is the leading cause of critical injury in the younger-than-40-year-old age group. (Source: T...
Source: Transfusion Medicine Reviews - December 17, 2014 Category: Hematology Authors: Rosemary L. Sparrow Source Type: research
Clinical Guidelines in Transfusion Medicine
In this issue of Transfusion Medicine Reviews, a prestigious group of experts present clinical guidance on the use of platelet transfusions for patients with hypoproliferative thrombocytopenia on behalf of the International Committee for Transfusion Medicine Guidelines (ICTMG). The ICTMG was established by the Canadian Blood Services in 2010 with a remit to develop evidence-based transfusion medicine guidelines to optimize transfusion care, and to increase the credibility of guideline development for transfusion medicine by using a widely collaborative effort and consistent up-to-date methodology. (Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - December 11, 2014 Category: Hematology Authors: Sunny Dzik, Michael F. Murphy Source Type: research
Journal Club
(Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - December 10, 2014 Category: Hematology Authors: Simon Stanworth, Richard Haspel, Jeannie Callum Source Type: research
Blood Component Use in a Sub-Saharan African country: Results of a 4-Year Evaluation of Diagnoses Associated With Transfusion Orders in Namibia
National blood use patterns in sub-Saharan Africa are poorly described. Although malaria and maternal hemorrhage remain important drivers of blood demand across Africa, economic growth and changes in malaria, HIV/AIDS, and noncommunicable disease epidemiology may contribute to changes in blood demand. We evaluated indications for blood use in Namibia, a country in southern Africa, using a nationally representative sample and discuss implications for the region. Clinical and demographic data related to the issuance of blood component units in Namibia were reviewed for a 4-year period (August 1, 2007–July 31, 2011). (Sourc...
Source: Transfusion Medicine Reviews - November 26, 2014 Category: Hematology Authors: John P. Pitman, Robert Wilkinson, Yang Liu, Bjorn von Finckenstein, Cees Th. Smit Sibinga, David W. Lowrance, Anthony A. Marfin, Maarten J. Postma, Mary Mataranyika, Sridhar V. Basavaraju Source Type: research
Blood component use in a sub-Saharan African country: Results of a four-year evaluation of diagnoses associated with transfusion orders in Namibia
National blood use patterns in sub-Saharan Africa are poorly described. While malaria and maternal hemorrhage remain important drivers of blood demand across Africa, economic growth and changes in malaria, HIV/AIDS, and non-communicable disease epidemiology may contribute to changes in blood demand. We evaluated indications for blood utilization in Namibia, a country in southern Africa, using a nationally representative sample and discuss implications for the region. Clinical and demographic data related to the issuance of blood component units in Namibia were reviewed for a four year period (August 1, 2007 - July 31, 2011...
Source: Transfusion Medicine Reviews - November 26, 2014 Category: Hematology Authors: John P. Pitman, Robert Wilkinson, Yang Liu, Bjorn von Finckenstein, Cees Th. Smit Sibinga, David W. Lowrance, Anthony A. Marfin, Maarten J. Postma, Mary Mataranyika, Sridhar V. Basavaraju Source Type: research
