When is a Positive Truly So? Defining a New Cut-Off in a Precautionary Approach to D Typing in Child-Bearing Age Female Individuals

Purpose: RHD typing in child bearing age females (CBAF) dictates who warrants Rh immunoprophylaxis and restriction to D-cellular products. “D+” has been defined as ≥2+ reactivity (irrespective of test modality) and assumes wildtype configuration/D tolerance. However, inter-reagent discrepancies may suggest sensitization-vulnerable variants. We sought to determine our rate of modality-related D-discrepancies, as defined by ≥2+ g el results despite weak or negative tube reads, and their correlative genotypic/clinical meaning.

Source: Transfusion Medicine Reviews - June 30, 2016 Category: Hematology Authors: Lisa Richards, Irene Skinner, Allan Lupish, Grant Johnson, Sally Balmer, Lani Lieberman, Yulia Lin, Jeannie Callum, Jacob Pendergrast, Christine Cserti-Gazdewich Source Type: research