Guidance on Platelet Transfusion for Patients with Hypoproliferative Thrombocytopenia

Patients with hypoproliferative thrombocytopenia are at an increased risk of hemorrhage and alloimmunization to platelets. Updated guidance for optimizing platelet transfusion therapy is needed as data from recent pivotal trials have the potential to change practice. This guideline, developed by a large international panel using a systematic search strategy and standardized methods to develop recommendations, incorporates recent trials not available when previous guidelines were developed. We found that prophylactic platelet transfusion for platelet counts less than or equal to 10 x 109/L is the optimal approach to decrease the risk of hemorrhage for patients requiring chemotherapy or undergoing allogeneic or autologous transplantation.

Source: Transfusion Medicine Reviews - November 26, 2014 Category: Hematology Authors: Susan Nahirniak, Sherrill J. Slichter, Susano Tanael, Paolo Rebulla, Katerina Pavenski, Ralph Vassallo, Mark Fung, Rene Duquesnoy, Chee-Loong Saw, Simon Stanworth, Alan Tinmouth, Heather Hume, Arjuna Ponnampalam, Catherine Moltzan, Brian Berry, Nadine She Source Type: research