Prophylactic use of tranexamic acid for postpartum bleeding outcomes: a systematic review and meta-analysis of randomized controlled trials

Despite multimodal approaches to treatment, postpartum hemorrhage (PPH) is a life threatening condition whose incidence continues to rise. In developing areas, such as sub-Saharan Africa, PPH is the leading cause of maternal mortality. Tranexamic acid (TXA) is a possible prophylactic treatment for the prevention of PPH. We performed a systematic review and meta-analysis of randomized trials comparing prophylactic TXA versus placebo or no treatment in term parturients to quantify the effects of prophylactic TXA administration on peripartum bleeding outcomes.

Source: Transfusion Medicine Reviews - July 16, 2015 Category: Hematology Authors: Asim Alam, Stephen Choi Source Type: research