Dengue Virus Persists in Stored Platelets and Red Blood Cells

Dengue virus (DENV), a positive-sense single-stranded RNA Flavivirus, infects ~390 million people annually. Significant viral load is seen in asymptomatic individuals resulting in transfusion-transmission and a threat to blood systems globally. It is currently unknown whether DENV can maintain its viability or even replicate during storage of cellular blood products. Therefore, we investigated the persistence of DENV (serotypes 1-4) in stored platelet (PC) and red blood cell concentrates (RCC) under standard blood bank conditions.

Source: Transfusion Medicine Reviews - July 1, 2014 Category: Hematology Authors: Michael R. Sutherland, Ayo Y. Simon, Katherine Serrano, Peter Schubert, Jason Acker, Ed L.G. Pryzdial Tags: Abstracts Source Type: research