Antioxidant status in oral subchronic toxicity of fipronil and fluoride co-exposure in buffalo calves
The effects of fipronil and fluoride co-exposure were investigated on antioxidant status of buffalo calves. A total of 24 healthy male buffalo calves divided into 4 groups were treated for 98 consecutive days. Group I, receiving no treatment, served as the control. Animals of groups II and III were orally administered with fipronil at the dosage of 0.5 mg/kg/day and sodium fluoride (NaF) at the dosage of 6.67 mg/kg/day, respectively, for 98 days. Group IV was coadministered with fipronil and NaF at the same dosages as groups II and III. Administration of fipronil alone produced significant elevation in lipid peroxidation (...
Source: Toxicology and Industrial Health - January 29, 2016 Category: Toxicology Authors: Gill, K. K., Dumka, V. K. Tags: Articles Source Type: research
Antibacterial effects of curcumin: An in vitro minimum inhibitory concentration study
Conclusion:
This study revealed antibacterial effects of curcumin against standard bacterial strains in high concentrations. Animal experiments have demonstrated that curcumin applied at high doses has strong antibacterial activity. There is a need for further in vivo studies to shed light on antibacterial effects of curcumin with high concentrations. (Source: Toxicology and Industrial Health)
Source: Toxicology and Industrial Health - January 29, 2016 Category: Toxicology Authors: Gunes, H., Gulen, D., Mutlu, R., Gumus, A., Tas, T., Topkaya, A. E. Tags: Articles Source Type: research
The protective effect of propylthiouracil against hepatotoxicity induced by chromium in adult mice
This study focused on the possible protective effect of propylthiouracil (PTU) against potassium dichromate (K2Cr2O7). Female mice were divided into four groups (groups I–IV) with seven animals in each group. Group I served as a control, which received tap water; group II received K2Cr2O7 alone (75 mg kg–1 body weight (b.w.)) via drinking water; group III received both K2Cr2O7 via drinking water and PTU by intramuscular injection at a dose 2.5 mg/100 g–1 b.w. twice a week, and group IV received PTU alone twice a week for 30 days. Exposure of mice to Cr promoted oxidative stress with an increase in malondi...
Source: Toxicology and Industrial Health - January 29, 2016 Category: Toxicology Authors: Ben Hamida, F., Troudi, A., Sefi, M., Boudawara, T., Zeghal, N. Tags: Articles Source Type: research
The effects of intravenous immunoglobulin on cerebral ischemia in rats: An experimental study
Stroke is one of the major reasons of death in the United States and related to adult disability. Despite aggressive research, the treatment approaches of stroke still remains a major clinical problem. Intravenous immunoglobulin (IVIg) is a polyspecific Ig G preparation obtained from plasma of several thousand healthy people (donors). IVIg is an important treatment approach and used for several disorders. The aim of this study was to investigate the potentially beneficial effects of IVIg therapy in experimentally induced ischemia in middle cerebral artery occlusion (MCAo) models of rats. A total of 30 adult male Sprague Da...
Source: Toxicology and Industrial Health - January 29, 2016 Category: Toxicology Authors: Tunik, S., Aluclu, M. U., Acar, A., Akkoc, H., Guzel, A., Alabalik, U., Akkus, M. Tags: Articles Source Type: research
The effects of exposure to titanium dioxide nanoparticles during lactation period on learning and memory of rat offspring
Nanoscale titanium dioxide (TiO2), which is massively produced and widely used in living environment, seems to have a potential risk on human health. The central nervous system (CNS) is the potential susceptible target of nanoparticles, but the studies on this aspect are limited so far. The aim of this study was to evaluate the effects of exposure to TiO2 nanoparticles during lactation period on learning and memory of offspring. Lactating Wistar rats were exposed to TiO2 nanoparticles (100 mg/kg; gavage) for 21 days. The Morris water maze and passive avoidance tests showed that the exposure to TiO2 nanoparticles could sign...
Source: Toxicology and Industrial Health - January 29, 2016 Category: Toxicology Authors: Mohammadipour, A., Hosseini, M., Fazel, A., Haghir, H., Rafatpanah, H., Pourganji, M., Bideskan, A. E. Tags: Articles Source Type: research
Target hazard quotient evaluation of cadmium and lead in fish from Caspian Sea
Heavy metals are being increasingly released into the natural waters from geological and anthropogenic sources. The distributions of several heavy metals such as cadmium (Cd) and lead (Pb) were investigated in muscle and liver of three different fish species seasonally collected from Caspian Sea (autumn 2011–summer 2012). The concentrations of all metals were lower in flesh than those recorded in liver due to their physiological roles. The target hazard quotient (THQ) index for fish was calculated. Estimation of THQ calculations for the contaminated fish consumption was calculated to evaluate the effect of pollution ...
Source: Toxicology and Industrial Health - January 29, 2016 Category: Toxicology Authors: Basim, Y., Khoshnood, Z. Tags: Articles Source Type: research
Studies on fate and toxicity of nanoalumina in male albino rats: Oxidative stress in the brain, liver and kidney
In conclusion, our data indicated that rats injected with nanoalumina suffered from the oxidative stresses that were dose and time dependent. In addition, Al2O3-NPs released into the biospheres could be potentiating a risk to the environment and causing hazard effects on living organisms, including mammals. (Source: Toxicology and Industrial Health)
Source: Toxicology and Industrial Health - January 29, 2016 Category: Toxicology Authors: Morsy, G. M., Abou El-Ala, K. S., Ali, A. A. Tags: Articles Source Type: research
Serum prolidase activity, oxidative stress, and antioxidant enzyme levels in patients with renal cell carcinoma
Conclusion:
Our results indicate that increased prolidase seems to be related to increased oxidative stress along with decreased antioxidant levels in renal cancer. (Source: Toxicology and Industrial Health)
Source: Toxicology and Industrial Health - January 29, 2016 Category: Toxicology Authors: Pirincci, N., Kaba, M., Gecit, I., Günes, M., Yüksel, M. B., Tanık, S., Arslan, A., Demir, H. Tags: Articles Source Type: research
Retraction notice
(Source: Toxicology and Industrial Health)
Source: Toxicology and Industrial Health - December 31, 2015 Category: Toxicology Tags: Articles Source Type: research
Antitumor characterization of various fractions of Launaea procumbens
The antitumor activity of various six fractions of Launaea procumbens were studied using the potato disk bioassay technique. Three concentrations (10, 100, and 1000 ppm) of all these six fractions were used for characterization of antitumor activity. Among these fractions, methanolic fraction exhibited significant inhibition of crown gall tumors caused by Agrobacterium tumefaciens followed by butanolic fraction. These results revealed that methanolic and butanolic fractions contain bioactive constituents responsible for inhibition of tumor. Further purification and characterization are in progress in our laboratory. (Sourc...
Source: Toxicology and Industrial Health - December 31, 2015 Category: Toxicology Authors: Khan, R. A., Khan, M. R., Shah, N. A., Sahreen, S., Elahi, S. N. Tags: Articles Source Type: research
Protective effect of ascorbic acid and Ginkgo biloba against learning and memory deficits caused by fluoride
Fluoride is present in the ground water, World Health Organization permitted level of fluoride in the ground water is 0.5 ppm. Tooth pastes, mouth washes, tea and sea fish are the sources of fluoride. Exposure to these multiple sources results in several adverse effects in addition to the fluorosis. The present study aimed to test the effect of vitamin C and Ginkgo biloba against the behavioural deficits caused by fluoride. Rats were divided into five groups with six animals in each group (n = 6). Control group received ordinary tap water with 0.5 ppm of fluoride, the remaining groups received 100 ...
Source: Toxicology and Industrial Health - December 31, 2015 Category: Toxicology Authors: Jetti, R., Raghuveer, C., Mallikarjuna, R. C. Tags: Articles Source Type: research
Physiological and biochemical changes after boldenone injection in adult rabbits
Boldenone (BOL) is an androgenic steroid that improves the growth and food conversion in food-producing animals. In most countries worldwide, this anabolic steroid is forbidden for human uses and meat production as it was developed for veterinary use. Recently, BOL is used by bodybuilders in both off season and pre-contest, where it is well known for increasing vascularity while preparing for a bodybuilding contest. The present study was designed to investigate the physiological and biochemical changes in rabbits after injection with the growth promoter BOL. A total of 32 adult New Zealand rabbits were divided into four gr...
Source: Toxicology and Industrial Health - December 31, 2015 Category: Toxicology Authors: Tousson, E., El-Moghazy, M., Massoud, A., El-Atrash, A., Sweef, O., Akel, A. Tags: Articles Source Type: research
In vitro assessment of cytogenetic and oxidative effects of {alpha}-pinene
In conclusion, the findings of the present study confirm for the first time that α-pinene could be a significant source of natural antioxidant compound that may have beneficial health effects. (Source: Toxicology and Industrial Health)
Source: Toxicology and Industrial Health - December 31, 2015 Category: Toxicology Authors: Türkez, H., Aydın, E. Tags: Articles Source Type: research
In silico interaction of methyl isocyanate with immune protein responsible for Mycobacterium tuberculosis infection using molecular docking
This article reports in silico analysis of methyl isocyanate (MIC) on different key immune proteins against Mycobacterium tuberculosis. The analysis shows that MIC is released in the Bhopal gas tragedy in 1984, which is highly toxic and extremely hazardous to human health. In this study, we have selected immune proteins to perform molecular docking with the help of Autodock 4.0. Results show that the CD40 ligand and alpha5beta1 integrin have higher inhibition compared to plasminogen activator urokinase, human glutathione synthetase, mitogen-activated protein kinase (P38 MAPK 14), surfactant protein-B, -D (SP-D), and pulmon...
Source: Toxicology and Industrial Health - December 31, 2015 Category: Toxicology Authors: Shrivastava, R., Yasir, M., Tripathi, M., Singh, P. Tags: Articles Source Type: research
Heavy metals content, phytochemical composition, antimicrobial and insecticidal evaluation of Elaeagnus angustifolia
Elaeagnus angustifolia was analyzed for determination of metals, phytoconstituents, bactericidal, fungicidal and insecticidal effects and to explore its chemical and biological potential. The root, branches, leaves, stem bark and root bark parts of E. angustifolia were found to contain iron, lead, copper, cadmium, zinc, chromium, nickel and cobalt in different concentrations. Crude extract of Elaeagnus angustifolia (Ea.Cr) was tested positive for the presence of alkaloids, flavonoids, saponins and tannins. Ea.Cr and its fractions, n-hexane (Ea.Hex), ethyl acetate (Ea.EtAc) and aqueous (Ea.Aq) showed bactericidal activity a...
Source: Toxicology and Industrial Health - December 31, 2015 Category: Toxicology Authors: Khan, S. U., Khan, A.-u., Shah, A.-u.-H. A., Shah, S. M., Hussain, S., Ayaz, M., Ayaz, S. Tags: Articles Source Type: research
