Blood pressure and occupational exposure to noise and lead (Pb): A cross-sectional study
Several studies have explored the hypothesis that low blood lead (PbB) and high noise levels may be associated with an increased risk of hypertension. To assess the possible relationship between occupational exposure to lead (Pb) and noise and elevated blood pressure, we studied 105 workers (age: 41.27 ± 6.25 years and length of employment: 4.12 ± 5.33 years) employed in a Pb battery recycling plant by measuring A-weighted equivalent sound level, PbB, -aminolevulinic acid dehydratase (ALAD) activity and zinc protoporphyrin (ZPP) levels and systolic and diastolic blood pressure (SBP and DBP). Results showed th...
Source: Toxicology and Industrial Health - September 27, 2016 Category: Toxicology Authors: Rapisarda, V., Ledda, C., Ferrante, M., Fiore, M., Cocuzza, S., Bracci, M., Fenga, C. Tags: Articles Source Type: research
Determination of mutagenicity and genotoxicity of indium tin oxide nanoparticles using the Ames test and micronucleus assay
In this study, the mutagenicity and genotoxicity of indium tin oxide (ITO) nanomaterial were assessed using two standard genotoxicity assays, the Salmonella reverse mutation assay (Ames test) and the in vitro micronucleus (MN) assay. Seven different concentrations (12.5, 25, 50, 75, 100, 125, and 150 µg/plate) of this nanomaterial were tested using the Ames test on the TA98 and TA100 strains in the presence and absence of the S9 mixture. At all the concentrations tested, this substance did not significantly increase the number of revertant colonies compared with the control with or without S9 mixture. The genotoxic e...
Source: Toxicology and Industrial Health - August 24, 2016 Category: Toxicology Authors: Akyıl, D., Eren, Y., Konuk, M., Tepekozcan, A., Saglam, E. Tags: Articles Source Type: research
Neurochemical impact of bisphenol A in the hippocampus and cortex of adult male albino rats
This study extends to investigate the effect of BPA on acetylcholinesterase (AchE) activity and some oxidative stress parameters in the two regions. In the cortex, a significant increase in the excitatory and a significant decrease in the inhibitory amino acids occurred after BPA (10 mg/kg for 10 weeks and 25 mg/kg for 6 weeks). This was accompanied by a significant increase in lipid peroxidation, nitric oxide, and reduced glutathione after 6 weeks of BPA (25 mg/kg). In the hippocampus, a significant increase in the excitatory and inhibitory amino acid neurotransmitters occurred after 6 weeks of BPA. Hippocampal lipid pero...
Source: Toxicology and Industrial Health - August 24, 2016 Category: Toxicology Authors: Khadrawy, Y. A., Noor, N. A., Mourad, I. M., Ezz, H. S. A. Tags: Articles Source Type: research
Effect of hexavalent chromium-treated sperm on in vitro fertilization and embryo development
Hexavalent chromium (Cr(VI)) is an environmental contaminant that is associated with reproductive abnormalities in both humans and animals. In the present study, we evaluated the cytotoxic effect of Cr(VI) on sperm function and subsequent embryo development after in vitro fertilization (IVF). Sperm obtained from BDF1 male mice were treated with potassium dichromate (0, 3.125, 6.25, 12.5, 25, or 50 μM) for 3 h. Cr(VI) significantly decreased sperm viability and acrosome reaction with increasing dose. These Cr(VI)-treated sperms were further used for IVF of oocytes obtained from BDF1 female mice. Results showed that Cr(VI...
Source: Toxicology and Industrial Health - August 24, 2016 Category: Toxicology Authors: Yoisungnern, T., Das, J., Choi, Y.-J., Parnpai, R., Kim, J.-H. Tags: Articles Source Type: research
Effects of aluminum chloride on serum proteins, bilirubin, and hepatic trace elements in chickens
The aim of this study was to reveal the effects of aluminum chloride (AlCl3) on the hepatic metabolism function and trace elements’ distribution. Two hundred healthy male chickens (1 day old) were intraperitoneally administered with AlCl3 (0, 18.31, 27.47, and 36.62 mg kg–1 day–1 of Al3+) consecutively for 3 days. Then the chickens were allowed to rest for 1 day. The cycle lasted four days. The cycle was repeated 15 times (60 days). The contents of serum total protein (TP), albumin (ALB), total bilirubin (TBI), direct bilirubin (DBI), hepatic aluminum (Al), copper (Cu), iron (Fe), and zinc (Zn) were exami...
Source: Toxicology and Industrial Health - August 24, 2016 Category: Toxicology Authors: Wang, B., Zhu, Y., Zhang, H., Liu, L., Li, G., Song, Y., Li, Y. Tags: Articles Source Type: research
The protective effects of prostaglandin E1 on lung injury following renal ischemia-reperfusion in rats
For the purposes of the present study, the protective effect of prostaglandin E1 (PGE1) on lung injury following renal ischemia–reperfusion (RIR) was investigated. Adult male rats were divided into four groups, namely, (I) control rats given physiological saline; (II) rats given PGE1 (20 μg/kg, intravenously); (III) rats subjected to RIR; and (IV) rats subjected to RIR given PGE1 30 min prior to ischemia and just before reperfusion. The right nephrectomy was performed in the RIR model. The left renal pedicle was occluded for 60 min to induce ischemia and then the left kidney was subjected to reperfusion for 60 min...
Source: Toxicology and Industrial Health - August 24, 2016 Category: Toxicology Authors: Oztay, F., Kara-Kisla, B., Orhan, N., Yanardag, R., Bolkent, S. Tags: Articles Source Type: research
Toxic effects of ionic liquid 1-octyl-3-methylimidazolium bromide on the antioxidant defense system of freshwater planarian, Dugesia japonica
The activities of antioxidant enzymes and the levels of glutathione (GSH) and malondialdehyde (MDA) were determined when freshwater planarian Dugesia japonica was exposed to different concentrations of 1-octyl-3-methylimidazolium bromide ([C8mim]Br) for one, three, and five days. The results showed that superoxide dismutase (SOD) activity began to increase in all treated groups after three days of exposure, while catalase (CAT) activity was inhibited after the first day, but increased notably on the fifth day except for the lowest concentration group. The activity of glutathione peroxidase (GPX) was induced from the first ...
Source: Toxicology and Industrial Health - August 24, 2016 Category: Toxicology Authors: Zhang, H.-C., Shi, C.-Y., Sun, L.-Q., Wang, F., Chen, G.-W. Tags: Articles Source Type: research
Low doses of mercuric chloride cause the main features of anti-nucleolar autoimmunity in female outbred CFW mice
The growth of the influence of anthropogenic factors aimed on the improvement of human life has its side effect, for example, living organisms receive increasing exposure to toxic mercuric compounds. Experimental data show that mercury (Hg) salts are able to induce systemic autoimmunity in rodents. This Hg-induced autoimmune process (HgIA) is characterized by T cell-dependent polyclonal activation of B lymphocytes, increased level of serum immunoglobulin G1 (IgG1) and immunoglobulin E (IgE), production of antinucleolar autoantibodies (ANoA), and immune complex deposition in multiple organs. HgIA in mice is used as a model ...
Source: Toxicology and Industrial Health - August 24, 2016 Category: Toxicology Authors: Arefieva, A. S., Kamaeva, A. G., Krasilshchikova, M. S. Tags: Articles Source Type: research
Mercuric chloride induced hepatotoxic and hematologic changes in rats: The protective effects of sodium selenite and vitamin E
This study focuses on investigating the possible protective effect of sodium selenite (Na2SeO3) and/or vitamin E against mercuric chloride (HgCl2)-induced hepatotoxicity in rat. Male rats were given HgCl2 (1 mg/kg body weight (bw)) and HgCl2 plus Na2SeO3 (0.25 mg/kg bw) and/or vitamin E (100 mg/kg bw) daily via gavage for 4 weeks. HgCl2-treated groups had significantly higher white blood cell and thrombocyte counts than the control group. Serum activities of alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, -glutamyl-transferase, and lactate dehydrogenase significantly increased and serum levels o...
Source: Toxicology and Industrial Health - August 24, 2016 Category: Toxicology Authors: Uzunhisarcikli, M., Aslanturk, A., Kalender, S., Apaydin, F. G., Bas, H. Tags: Articles Source Type: research
Cytotoxic and genotoxic evaluation of different synthetic amorphous silica nanomaterials in the V79 cell line
The nature of occupational risks and hazards in industries that produce or use synthetic amorphous silica (SAS) nanoparticles is still under discussion. Manufactured SAS occur in amorphous form and can be divided into two main types according to the production process, namely, pyrogenic silica (powder) and precipitated silica (powder, gel or colloid). The physical and chemical properties of SAS may vary in terms of particle size, surface area, agglomeration state or purity, and differences in their toxicity potential might therefore be expected. The aim of this study was to compare the cytotoxicity and genotoxicity of repr...
Source: Toxicology and Industrial Health - August 24, 2016 Category: Toxicology Authors: Guichard, Y., Fontana, C., Chavinier, E., Terzetti, F., Gate, L., Binet, S., Darne, C. Tags: Articles Source Type: research
Annexin A5 promotes macrophage activation and contributes to pulmonary fibrosis induced by silica particles
Conclusions:
These findings define a role of annexin A5 in promoting macrophage activation via Fas/FasL pathways in silica-induced lung fibrosis. (Source: Toxicology and Industrial Health)
Source: Toxicology and Industrial Health - August 24, 2016 Category: Toxicology Authors: Luo, C., Ji, X., Fan, J., Hou, Z., Wang, T., Wu, B., Ni, C. Tags: Articles Source Type: research
Biosorption of heavy metals by Pseudomonas species isolated from sugar industry
This study revealed that Pseudomonas sp. may provide a new microbial community that can be used for enhanced remediation of contaminated environment. (Source: Toxicology and Industrial Health)
Source: Toxicology and Industrial Health - August 24, 2016 Category: Toxicology Authors: Naz, T., Khan, M. D., Ahmed, I., Rehman, S. u., Rha, E. S., Malook, I., Jamil, M. Tags: Articles Source Type: research
Effect of N-acetylcysteine administration on homocysteine level, oxidative damage to proteins, and levels of iron (Fe) and Fe-related proteins in lead-exposed workers
N-Acetylcysteine (NAC) could be included in protocols designed for the treatment of lead toxicity. Therefore, in this study, we decided to investigate the influence of NAC administration on homocysteine (Hcy) levels, oxidative damage to proteins, and the levels of iron (Fe), transferrin (TRF), and haptoglobin (HPG) in lead (Pb)-exposed workers. The examined population (n = 171) was composed of male employees who worked with Pb. They were randomized into four groups. Workers who were not administered any antioxidants, drugs, vitamins, or dietary supplements were classified as the reference group (n = 49). The remaining thre...
Source: Toxicology and Industrial Health - August 24, 2016 Category: Toxicology Authors: Kasperczyk, S., Dobrakowski, M., Kasperczyk, A., Romuk, E., Rykaczewska-Czerwinska, M., Pawlas, N., Birkner, E. Tags: Articles Source Type: research
Reproductive toxicity in male mice after exposure to high molybdenum and low copper concentrations
To evaluate the effects of dietary high molybdenum (HMo) and low copper (LCu) concentrations on reproductive toxicity of male mice, 80 mice were divided into 4 groups of 20. These groups were fed with the following: (1) normal control (NC) diet (NC group); (2) NC and HMo diets (HMo group); (3) LCu diet (LCu group); and (4) HMo and LCu diets (HMoLCu group). On the 50th and 100th day, superoxide dismutase (SOD), malondialdehyde (MDA), glutathione peroxidase (GSH-Px), and total antioxidant capacity (T-AOC) were analyzed to determine oxidative stress states. Morphological changes in testicular tissue were evaluated with hemato...
Source: Toxicology and Industrial Health - August 24, 2016 Category: Toxicology Authors: Wang, H.-w., Zhou, B.-h., Zhang, S., Guo, H.-w., Zhang, J.-l., Zhao, J., Tian, E.-j. Tags: Articles Source Type: research
Cytochrome P450 2E1 is responsible for the initiation of 1,2-dichloropropane-induced liver damage
1,2-Dichloropropane (1,2-DCP), a solvent, which is the main component of the cleaner used in the offset printing companies in Japan, is suspected to be the causative agent of bile duct cancer, which has been recently reported at high incidence in those offset printing workplaces. While there are some reports about the acute toxicity of 1,2-DCP, no information about its metabolism related to toxicity in animals is available. As part of our efforts toward clarifying the role of 1,2-DCP in the development of cancer, we studied the metabolic pathways and the hepatotoxic effect of 1,2-DCP in mice with or without cytochrome P450...
Source: Toxicology and Industrial Health - August 24, 2016 Category: Toxicology Authors: Yanagiba, Y., Suzuki, T., Suda, M., Hojo, R., Gonzalez, F. J., Nakajima, T., Wang, R.-S. Tags: Articles Source Type: research
