Chronic exposure of Rutilus rutilus caspicus fingerlings to ambient copper: Effects on food intake, growth performance, biochemistry and stress resistance
An 8-week trial was conducted to investigate the effect of ambient copper (Cu) on growth performance, physiological characteristics and stress resistance of Caspian roach, Rutilus rutilus caspicus. Fish were exposed to 0 (control), 0.02, 0.04 and 0.06 ppm Cu, and their food intake and growth performance were fortnightly recorded. Also, serum cortisol, glucose, alanine aminotransferase (ALT) and sodium (Na) levels were determined after 2 and 8 weeks exposure to ambient Cu. At the end of trial, serum total protein, albumin, globulin and albumin–globulin ratio (A:G) levels, whole body proximate composition and stre...
Source: Toxicology and Industrial Health - January 29, 2016 Category: Toxicology Authors: Hoseini, S. M., Rajabiesterabadi, H., Kordrostami, S. Tags: Articles Source Type: research
Vanadium inhalation induces actin changes in mice testicular cells
We reported immunohistochemical changes in actin testicular cytoskeleton in a vanadium inhalation experimental mice model. Our findings show that exposure to vanadium pentoxide (0.02 M) results in actin decrease in testicular cells from 3–12 weeks exposure time; this effect was statistically significant and exposure time dependent. Actin cytoskeleton damage is a mechanism that could explain vanadium reprotoxic effects and its association with impaired fertility. (Source: Toxicology and Industrial Health)
Source: Toxicology and Industrial Health - January 29, 2016 Category: Toxicology Authors: Rodriguez-Lara, V., Morales-Rivero, A., Rivera-Cambas, A. M., Fortoul, T. I. Tags: Articles Source Type: research
The potential chemoprotective effects of melatonin against genotoxicity induced by diazinon in human peripheral blood lymphocytes
The protection afforded by melatonin (MLT) against diazinon (DZN)-induced micronucleus formation, an index of DNA damage, in human blood lymphocytes was investigated. Whole blood samples were collected from five volunteers and were incubated with MLT at different concentrations (100, 200, 300, and 400 µM final concentration) for 1 h. The samples were then incubated with 750 µM DZN for 1 h. Subsequently, the lymphocytes were cultured with a mitogenic stimulant to evaluate micronucleus formation in cytokinesis-blocked binucleated cells. The incubation of lymphocytes with DZN induces additional genotoxicity. Pretr...
Source: Toxicology and Industrial Health - January 29, 2016 Category: Toxicology Authors: Karamian, A., Shokrzadeh, M., Ahmadi, A. Tags: Articles Source Type: research
Studies on fate and toxicity of nanoalumina in male albino rats: Lethality, bioaccumulation and genotoxicity
In conclusion, Al has a high affinity to get accumulated in tissues to a level that is able to induce genotoxicity. Therefore, bioaccumulation is time, dose and organ dependant. (Source: Toxicology and Industrial Health)
Source: Toxicology and Industrial Health - January 29, 2016 Category: Toxicology Authors: Morsy, G. M., El-Ala, K. S. A., Ali, A. A. Tags: Articles Source Type: research
Protective effects of caffeic acid phenethyl ester on ifosfamide-induced central neurotoxicity in rats
Conclusion:
This study revealed that pretreatment with CAPE might protect brain tissue against IFOS-induced central neurotoxicity. CAPE could be an effective course of therapy to enhance therapeutic efficacy and to lessen IFOS toxicity in clinical chemotherapy. (Source: Toxicology and Industrial Health)
Source: Toxicology and Industrial Health - January 29, 2016 Category: Toxicology Authors: Ginis, Z., Ozturk, G., Albayrak, A., Kurt, S. N., Albayrak, M., Fadillioglu, E. Tags: Articles Source Type: research
Mobile phone radiation during pubertal development has no effect on testicular histology in rats
Mobile phones are extensively used throughout the world. There is a growing concern about the possible public health hazards posed by electromagnetic radiation emitted from mobile phones. Potential health risk applies particularly to the most intensive mobile phone users—typically, young people. The aim of this study was to investigate the effects of mobile phone exposure to the testes, by assessing the histopathological and biochemical changes in the testicular germ cells of rats during pubertal development. A total of 12 male Sprague Dawley rats were used. The study group (n = 6) was exposed to a mobile p...
Source: Toxicology and Industrial Health - January 29, 2016 Category: Toxicology Authors: Tumkaya, L., Kalkan, Y., Bas, O., Yilmaz, A. Tags: Articles Source Type: research
Investigation of cadmium pollution in the spruce saplings near the metal production factory
Toxic metals such as lead and cadmium are among the pollutants that are created by the metal production factories and disseminated in the nature. In order to study the quantity of cadmium pollution in the environment of the metal production factories, 50 saplings of the spruce species at the peripheries of the metal production factories were examined and the samples of the leaves, roots, and stems of saplings planted around the factory and the soil of the environment of the factory were studied to investigate pollution with cadmium. They were compared to the soil and saplings of the spruce trees planted outside the factory...
Source: Toxicology and Industrial Health - January 29, 2016 Category: Toxicology Authors: Hashemi, S. A., Farajpour, G. Tags: Articles Source Type: research
Intervention of ginger or propolis ameliorates methotrexate-induced ileum toxicity
The long-term clinical use of methotrexate (MTX) is restricted due to its severe intestinal toxicity. The protective effect of ginger or propolis on the toxicity induced by MTX is relatively less understood, so the possible protective effect of ginger or propolis, used separately, was investigated. A total of 60 male albino rats were divided into six groups as follows: (1) control group; (2) ginger group; (3) propolis group; (4) MTX group; (5) ginger + MTX group; and (6) propolis + MTX group. The present results show that MTX caused ileum injury, including shortening and fusion of the villi, inflammatory cell infiltration ...
Source: Toxicology and Industrial Health - January 29, 2016 Category: Toxicology Authors: Abdul-Hamid, M., Salah, M. Tags: Articles Source Type: research
Impact of caffeic acid phenethyl ester treatment on vancomycin-induced pancreatic damage in rats
This study investigates the preventive effect of caffeic acid phenethyl ester (CAPE) on pancreatic damage induced by vancomycin (VCM) in rats. Rats were equally divided into three groups: group I (control), group II (only VCM-treated group) and group III (VCM + CAPE-treated groups). VCM was intraperitoneally administered at a dose of 200 mg kg–1twice daily for 7 days. CAPE was administered orally at 10 µM mL–1 kg–1 dose once daily for 7 days. The first dose of CAPE administration was performed 24 h prior to VCM injection. Blood and pancreas tissue sa...
Source: Toxicology and Industrial Health - January 29, 2016 Category: Toxicology Authors: Koyu, A., Gokalp, O., Gumral, N., Oktem, F., Karahan, N., Yilmaz, N., Saygin, M. Tags: Articles Source Type: research
Histopathological alterations after a growth promoter boldenone injection in rabbits
In conclusion, using BOL, while preparing for a young bodybuilding contest, may cause an alteration in the histological structure of most of the body organs; these findings suggested that especially young people who misuse anablic androgenic steroids should be careful if they want to use such steroids to enhance their strength and endurance. (Source: Toxicology and Industrial Health)
Source: Toxicology and Industrial Health - January 29, 2016 Category: Toxicology Authors: Tousson, E. Tags: Articles Source Type: research
Hepatoprotective role of Nicotiana plumbaginifolia Linn. against carbon tetrachloride-induced injuries
Nicotiana plumbignifolia (Linn) is used as folk medicine in the treatment of liver dysfunction in Pakistan. The present study was designed to investigate the hepatoprotective role of N. plumbignifolia methanolice extract (NPME) against carbon tetrachloride (CCl4)-induced oxidative damage in liver of chicks. Methanolic extract of N. plumbignifolia was obtained and was further evaluated as a hepatoprotective agent against CCl4-induced oxidative damage in liver of chicks. For this study, 60-day-old 50 male chicks were divided into five groups. Chicks of group 1 (control) had free access to food and water. Group II received 1 ...
Source: Toxicology and Industrial Health - January 29, 2016 Category: Toxicology Authors: Shah, A. S., Khan, R. A., Ahmed, M., Muhammad, N. Tags: Articles Source Type: research
Evaluation of teratogenic effects of crocin and safranal, active ingredients of saffron, in mice
This study suggests that crocin or safranal can induce embryonic malformations when administered in pregnant mice. Due to the wide use of saffron, further elaborate studies to understand the malformation mechanisms of these ingredients are recommended. (Source: Toxicology and Industrial Health)
Source: Toxicology and Industrial Health - January 29, 2016 Category: Toxicology Authors: Moallem, S. A., Afshar, M., Etemad, L., Razavi, B. M., Hosseinzadeh, H. Tags: Articles Source Type: research
Effects of aflatoxin B1 on oxidative stress markers and apoptosis of spleens in broilers
The purpose of the present study was to investigate the oxidative damage and apoptosis induced by aflatoxin B1 (AFB1) in spleen of broilers. A total of 200 one-day-old avian male broilers were randomly divided into 4 equal groups of 50 each and were fed for 21 days as follows: a control diet and three AFB1 diets containing 0.15, 0.3, and 0.6 mg AFB1/kg diet. Consumption of AFB1 diets induced oxidative stress in the spleen of chicken as evidenced by reduced glutathione peroxidase, glutathione reductase, and catalase activities, decreased glutathione contents, and increased malondialdehyde contents in explaining th...
Source: Toxicology and Industrial Health - January 29, 2016 Category: Toxicology Authors: Chen, J., Chen, K., Yuan, S., Peng, X., Fang, J., Wang, F., Cui, H., Chen, Z., Yuan, J., Geng, Y. Tags: Articles Source Type: research
Bioinoculants: A sustainable approach to maximize the yield of Ethiopian mustard (Brassica carinata L.) under low input of chemical fertilizers
This study aimed to find out the effect of plant growth-promoting rhizobacteria (PGPR; Azospirillum brasilense and Azotobacter vinelandii) either alone or in combination with different doses of nitrogen and phosphate fertilizers on growth, seed yield, and oil quality of Brassica carinata (L.) cv. Peela Raya. PGPR were applied as seed inoculation at 106 cells/mL-1 so that the number of bacterial cells per seed was 2.6 x 105 cells/seed. The chemical fertilizers, namely, urea and diammonium phosphate (DAP) were applied in different doses (full dose (urea 160 kg ha-1 + DAP 180 kg ha-1), half dose (urea 80 kg ha-1 + DAP 90 kg h...
Source: Toxicology and Industrial Health - January 29, 2016 Category: Toxicology Authors: Nosheen, A., Bano, A., Ullah, F. Tags: Articles Source Type: research
Assessment of metal contents in spices and herbs from Saudi Arabia
In the recent years, there has been a growing interest in monitoring heavy metal contamination of spices/herbs. Spices and herbs are sources of many bioactive compounds that can improve the tastes of food as well as influence digestion and metabolism processes. In the present study, the levels of some essential and toxic elements such as iron (Fe), zinc (Zn), copper (Cu), chromium (Cr), manganese (Mn), cobalt (Co), nickel (Ni), lead (Pb), and cadmium (Cd), present in common spices/herbs that were purchased from the local market in Saudi Arabia, were analyzed by atomic absorption spectroscopy after digestion with nitric aci...
Source: Toxicology and Industrial Health - January 29, 2016 Category: Toxicology Authors: Seddigi, Z. S., Kandhro, G. A., Shah, F., Danish, E., Soylak, M. Tags: Articles Source Type: research
