Amelioration of hepatotoxicity induced by aflatoxin using citrus fruit oil in broilers (Gallus domesticus)
This study was conducted to evaluate the efficacy of citrus fruit oil (CFO; 2.5 g kg–1) on the clinicopathological changes in broilers fed with diets containing 1 ppm of aflatoxin (AF). A total of 160 Ross 308 broiler chicks of 1-day-old were procured from a commercial hatchery, divided randomly on 7th day of age into four groups with two replicates of 20 birds each and fed with basal diet (group A), basal diet + CFO (group B), basal diet + AF (group C) and CFO + basal diet + AF (group D). The gross and histopathological changes in the liver, kidney, spleen, thym...
Source: Toxicology and Industrial Health - October 23, 2015 Category: Toxicology Authors: Kumar, D. S., Rao, S., Satyanarayana, M., Kumar, P. P., Anitha, N. Tags: Articles Source Type: research
Ameliorative effect of butylated hydroxyanisole against ferric nitrilotriacetate-induced hepatotoxicity and oxidative stress in rats
Ferric nitrilotriacetate (Fe-NTA) is a known renal carcinogen and has been shown to adversely induce oxidative stress and tissue toxicity after both acute and chronic exposure. Present studies were designed to study the hepatoprotective and antioxidant potential of butylated hydroxyanisole (BHA), a phenolic antioxidant used in foods on ferric nitrilotriacetate (Fe-NTA) induced hepatotoxicity in rats. Male albino rats of Wistar strain (4–6 weeks old) weighing 125–150 g were used in this study. Animals were given a single dose of Fe-NTA (9 mg/kg body weight, intraperitoneal) after a week’s treatment with BH...
Source: Toxicology and Industrial Health - October 23, 2015 Category: Toxicology Authors: Ansar, S., Iqbal, M. Tags: Articles Source Type: research
Protective effect of wogonin on proinflammatory cytokine generation via Jak1/3-STAT1/3 pathway in lipopolysaccharide stimulated BV2 microglial cells
Wogonin is a flavonoid compound which exhibits antioxidation, anti-inflammation, neuroprotection, and antitumorgenesis functions. However, the mechanism of how wogonin reduces proinflammatory cytokine generation in activated microglia is unclear. At present, we found wogonin inhibited lipopolysaccharide (LPS)-/interferon- (INF-)-induced generation of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α). Wogonin exhibited parallel inhibition on LPS-/INF--induced expression of IL-6 and TNF-α messenger RNA at the same concentration range. LPS-/INF--induced phosphorylation of signal transduction and trans...
Source: Toxicology and Industrial Health - September 25, 2015 Category: Toxicology Authors: Yeh, C.-H., Shih, H.-C., Hong, H.-M., Lee, S.-S., Yang, M.-L., Chen, C.-J., Kuan, Y.-H. Tags: Articles Source Type: research
Modulation of carbon tetrachloride-induced nephrotoxicity in rats by n-hexane extract of Sonchus asper
In this study, 24 male albino rats (190–200 g) were equally divided into four groups. Group I (control group) was given saline (1 ml/kg body weight (b.w.), 0.85% NaCl) and dimethyl sulfoxide (1 ml/kg b.w.); group II was treated with CCl4 (1 ml/kg b.w. intraperitoneally); groups III and IV were administered with CCl4 and after 48 h with S. asper n-hexane extract (SHE; 100 and 200 mg/kg b.w.). All the treatments were given twice a week for 4 weeks. The results revealed that CCl4-induced oxidative stress as evidenced by the significant depletion of antioxidant enzymes, namely, superoxide dismutase, catalase, peroxidase,...
Source: Toxicology and Industrial Health - September 25, 2015 Category: Toxicology Authors: Khan, R. A., Khan, M. R., Shah, N. A., Sahreen, S., Siddiq, P. Tags: Articles Source Type: research
Exposure to mercury among dental health workers in Turkey: Correlation with amalgam work and own fillings
Conclusion:
Preventive measures for protection from exposure to Hg are necessary for occupational health in dentistry and proper industrial hygiene rules should be emphasized to avoid contamination during work. (Source: Toxicology and Industrial Health)
Source: Toxicology and Industrial Health - September 25, 2015 Category: Toxicology Authors: Yılmaz, H., Tutkun, E., Demiralp, K. O., Yılmaz, F. M., Aliyev, V., Soylemezoglu, T. Tags: Articles Source Type: research
Ameliorative effect of lycopene against 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced rat liver microsomal toxicity: An in vitro study
In conclusion, the findings of the study indicate that TCDD induces a significant oxidative stress in liver microsomes as manifested by increased LPO, H2O2 production, protein carbonyl content and activities of UDPGT and P450 and decreased antioxidant enzymes activities and thiol content. By the reversal of biochemical and oxidative markers toward normalcy, the protective role of lycopene is illuminated in rat liver microsomal toxicity. (Source: Toxicology and Industrial Health)
Source: Toxicology and Industrial Health - September 25, 2015 Category: Toxicology Authors: Aly, H. A., El-Shitany, N. A., El-Beshbishy, H. A., Ashour, O. M. Tags: Articles Source Type: research
Physiological and biochemical mechanisms of allelopathy mediated by the allelochemical extracts of Phytolacca latbenia (Moq.) H. Walter
In allelopathy, one plant suppresses the growth and development of other plant/plants by negatively affecting a variety of physiological and biochemical reactions. We checked the effects of methanolic extracts (allelochemical extracts) of Phytolacca latbenia (Moq.) H. Walter on antioxidant enzyme activities such as peroxidases (PODs), super oxide dismutases (SODs) and catalase (CAT) and on total protein contents (TPC), cellular injury (CI), and malondialdehyde (MDA) in the germinating seeds of Brassica napus L. (dicot) and Triticum aestivum L. (monocot). Both the crude methanolic extract root (CMER) and crude methanolic ex...
Source: Toxicology and Industrial Health - September 25, 2015 Category: Toxicology Authors: Ullah, N., Haq, I. U., Safdar, N., Mirza, B. Tags: Articles Source Type: research
Hypermethylation of P15, P16, and E-cadherin genes in ovarian cancer
In conclusion, Dysfunction of the cell cycle and/or the cell–cell adhesion molecule plays a role in the pathogenesis of ovarian cancer and that the analysis of the methylation of p15 and E-cadherin genes can provide clinically important evidence on which to base the treatment. (Source: Toxicology and Industrial Health)
Source: Toxicology and Industrial Health - September 25, 2015 Category: Toxicology Authors: Moselhy, S. S., Kumosani, T. A., Kamal, I., Jalal, J., Jabaar, H. S. A., Dalol, A. Tags: Articles Source Type: research
Attenuation of erythrocytic actylcholinesterase by antidepressants: Evidence in an in vitro experiment
The current study was aimed to scrutinize acetylcholinesterase (AchE) inhibitory profile of two antidepressants, diazepam and phenobarbitone. The experimental designed was based on Michaelis–Menten parameters (apparent Michaelis constant (aKm) and apparent maximum velocity (aVm)) that estimate inhibition (%) as well as the type of inhibition (mechanism). The results showed marked inhibition of AchE by diazepam and the values of aKm and aVm were 65.5% and 52.63%, respectively. These values suggested a competitive type of antagonism for diazepam. Similar trend of antagonism was shown by phenobarbitone when it was subje...
Source: Toxicology and Industrial Health - September 25, 2015 Category: Toxicology Authors: Tariq, S. A., Khan, H., Muhammad, N. Tags: Articles Source Type: research
Ultrasonic synthesis, characterization of {beta}-aminoketones by bismuth(III) triflate and determination of antigenotoxic properties
This study was designed to evaluate the mutagenic and antimutagenic potential of synthesized β-aminoketones compounds using Ames/Salmonella and Escherichia coli WP2 bacterial reverse mutation assay systems. (Source: Toxicology and Industrial Health)
Source: Toxicology and Industrial Health - September 25, 2015 Category: Toxicology Authors: Ozturkcan, S. A., Turhan, K., Turgut, Z., Karadayi, M., Gulluce, M. Tags: Articles Source Type: research
UVA photoirradiation of benzo[a]pyrene metabolites: induction of cytotoxicity, reactive oxygen species, and lipid peroxidation
In this study, we determined that metabolism of BaP by human skin HaCaT keratinocytes resulted in six identified phase I metabolites, for example, BaP trans-7,8-dihydrodiol (BaP t-7,8-diol), BaP t-4,5-diol, BaP t-9,10-diol, 3-hydroxybenzo[a]pyrene (3-OH-BaP), BaP (7,10/8,9)tetrol, and BaP (7/8,9,10)tetrol. The photocytotoxicity of BaP, 3-OH-BaP, BaP t-7,8-diol, BaP trans-7,8-diol-anti-9,10-epoxide (BPDE), and BaP (7,10/8,9)tetrol in the HaCaT keratinocytes was examined. When irradiated with 1.0 J/cm2 UVA light, these compounds when tested at doses of 0.1, 0.2, and 0.5 μM, all induced photocytotoxicity in a dose-dependen...
Source: Toxicology and Industrial Health - September 25, 2015 Category: Toxicology Authors: Xia, Q., Chiang, H.-M., Yin, J.-J., Chen, S., Cai, L., Yu, H., Fu, P. P. Tags: Articles Source Type: research
Trace and major element levels in rats after oral administration of diesel and biodiesel derived from opium poppy (Papaver somniferum L.) seeds
The study investigated the toxic effects of diesel and biodiesel derived from opium poppy (Papaver somniferum L.) oil seeds on the trace and major elements in kidney, lung, liver, and serum of rats. By the end of 21 days, trace and major element concentrations in kidney, lung, and liver tissues and the serum were measured using inductively coupled plasma–optical emission spectroscopy. We observed that trace and major element levels in kidney, lung, and liver tissues and the serum changed. Especially, important differences were detected in trace and major element concentrations in kidney and lung tissues. In kidney ti...
Source: Toxicology and Industrial Health - September 25, 2015 Category: Toxicology Authors: Aksoy, L., Sozbilir, N. B. Tags: Articles Source Type: research
Sensitive determination of lead, cadmium and nickel in soil, water, vegetable and fruit samples using STAT-FAAS after preconcentration with activated carbon
In this study, lead (Pb), cadmium (Cd) and nickel (Ni) were determined in soil, water, vegetable and fruit samples taken from around oil refinery region in Batman, Turkey. Digestion procedures for samples were optimized and all optimum parameters were used both in digestion and in determination steps. In order to determine Pb and Cd, slotted tube atom trap (STAT) was used to increase the sensitivity in atomic absorption spectrophotometry. Preconcentration procedure under the optimum conditions was applied to water, vegetable and fruit samples to determine Pb, Cd and Ni in trace levels. In soil samples, concentrations of an...
Source: Toxicology and Industrial Health - September 25, 2015 Category: Toxicology Authors: Keskin, G., Bakirdere, S., Yaman, M. Tags: Articles Source Type: research
Histological, ultrastructural and immunohistochemical studies on the protective effect of ginger extract against cisplatin-induced nephrotoxicity in male rats
The objective of this work was to evaluate the protective effect of ginger extract (GE) against CP-induced nephrotoxicity. CP group displayed a marked renal failure characterized by a significant increase in serum creatinine and blood urea nitrogen (BUN) levels in addition to severe histopathological and ultrastructural renal alterations. Also, CP group showed an increase in the immunohistochemical expression of Bax proapoptotic protein. In contrast, GE+CP group showed significant decrease in the elevated serum creatinine and BUN levels and an improvement in the histopathological and ultrastructural renal injury induced by...
Source: Toxicology and Industrial Health - September 25, 2015 Category: Toxicology Authors: Ali, D. A., Abdeen, A. M., Ismail, M. F., Mostafa, M. A. Tags: Articles Source Type: research
Protective effects of green tea on antioxidative biomarkers in chemical laboratory workers
In conclusion, using GT as a dietary supplement can be a rational protocol to control source of hazards in chemical laboratory workers. (Source: Toxicology and Industrial Health)
Source: Toxicology and Industrial Health - September 1, 2015 Category: Toxicology Authors: Tavakol, H. S., Akram, R., Azam, S., Nahid, Z. Tags: Articles Source Type: research
