Effects of prenatal exposure to single-wall carbon nanotubes on reproductive performance and neurodevelopment in mice
In conclusion, the present results demonstrated small changes in offspring sensory and motor development following exposure to SWCNTs and support the idea that SWCNT risk assessment merits further investigation. (Source: Toxicology and Industrial Health)
Source: Toxicology and Industrial Health - June 26, 2016 Category: Toxicology Authors: Ivani, S., Karimi, I., Tabatabaei, S. R. F., Syedmoradi, L. Tags: Articles Source Type: research
The regulatory role of nickel on H3K27 demethylase JMJD3 in kidney cancer cells
In this study, kidney cancer cells namely human embryonic kidney 293-containing SV40 large T-antigen (HEK293T) and 786-0 were incubated with various concentrations of nickel chloride for 24 h before analysing the expression of three histone H3K27 methylation-modifying enzymes and H3K27me3 using quantitative real-time polymerase chain reaction, Western blot and immunofluorescence analyses. Our results showed that incubation of nickel chloride upregulated the expression of H3K27me3 demethylase jumonji domain-containing protein 3 (JMJD3) in kidney cancer cells, which was accompanied by the reduction in the protein level of H3...
Source: Toxicology and Industrial Health - June 26, 2016 Category: Toxicology Authors: Guo, X., Zhang, Y., Zhang, Q., Fa, P., Gui, Y., Gao, G., Cai, Z. Tags: Articles Source Type: research
Quercetin ameliorates atrazine-induced changes in the testicular function of rats
The protective effect of quercetin (QT) on atrazine (ATZ)-induced testicular damage in rats was investigated. Sexually mature male Wistar rats (weighing 220–250 g) divided into four groups with six animals in each group were given ATZ (120 mg kg–1; 1/16 of the median lethal dose for an oral dose) and/or QT (10 mg kg–1) daily via gavage for 16 days. By the end of day 16, rats given ATZ alone had significantly lower sperm counts, daily spermatozoa production, and sperm motility and significantly higher abnormal sperm numbers than the untreated control rats. The rats given ATZ alone also had significantly de...
Source: Toxicology and Industrial Health - June 26, 2016 Category: Toxicology Authors: Abarikwu, S. O., Farombi, E. O. Tags: Articles Source Type: research
Protective role of Nigella sativa oil against reproductive toxicity, hormonal alterations, and oxidative damage induced by chlorpyrifos in male rats
This study is aimed at elucidating the possible protective effects of Nigella sativa oil (NSO) in alleviating the toxicity of chlorpyrifos (CPF) on reproductive performance in male rats. Animals were orally administered with NSO (1 ml/kg/day), CPF (20 mg/kg/day), and NSO + CPF every day for 4 weeks. Results showed that CPF decreased spermatid number, sperm count, daily sperm production, and sperm motility while increased dead sperm and abnormal sperm compared with the control. Also the levels of testosterone, thyroxine levels, steroidogenic enzyme 17-ketosteroid reductase, body weight, food intake, and relative weight of r...
Source: Toxicology and Industrial Health - June 26, 2016 Category: Toxicology Authors: Mosbah, R., Yousef, M. I., Maranghi, F., Mantovani, A. Tags: Articles Source Type: research
Effects of T-2 mycotoxin on in vitro development and chromatin status of mouse embryos in preimplantation stages
T-2 toxin is a mycotoxin produced by phytopathogenic fungi of the Fusarium genus and has many well-studied deleterious effects on mammalian cells and reproductive tract. Despite the wide scale studies, the effects on preimplantation stage embryos are lacking. The aim of our study was to investigate the impact of T-2 on the cleavage stage of mouse embryos with regard to development to blastocysts and nuclear chromatin status.
Six-weeks-old BDF1 female mice were superovulated and placed together overnight with mature males. Zygotes were flushed 20 h after human chorionic gonadotropin injection and divided randomly into treat...
Source: Toxicology and Industrial Health - June 26, 2016 Category: Toxicology Authors: Somoskoi, B., Kovacs, M., Cseh, S. Tags: Articles Source Type: research
Antinociceptive and anti-inflammatory potential of Rhododendron arboreum bark
In conclusion, R. arboreum crude methanolic extract and its fractions exhibited anti-inflammatory and antinociceptive effects. For these reasons, this plant could be a promising source of new compounds for the management of pain and inflammatory diseases. (Source: Toxicology and Industrial Health)
Source: Toxicology and Industrial Health - June 26, 2016 Category: Toxicology Authors: Nisar, M., Ali, S., Muhammad, N., Gillani, S. N., Shah, M. R., Khan, H., Maione, F. Tags: Articles Source Type: research
The effect of benzo[{alpha}]pyrene on expression and signaling cross talk of aryl hydrocarbon receptor and NFATc1 in mouse lung tissue
Conclusion:
AhR expression is dependent on NFATc1 activation, and NFATc1 inhibition remarkably decreases AhR expression. However, it seems that total expression of NFATc1 is not dependent on AhR expression or activation. Moreover, CsA can prevent B[α]P-induced lung tissue damage, and it remarkably decreases NFATc1 expression. The results from this study point toward the molecular interactions of AhR and NFATc1 activation in lung tissue and the benefit of CsA treatment in B[α]P-induced lung damage. (Source: Toxicology and Industrial Health)
Source: Toxicology and Industrial Health - June 26, 2016 Category: Toxicology Authors: Parsa, M., Ostad, S. N., Moogahi, S. M. H. N., Bayat, M., Ghahremani, M. H. Tags: Articles Source Type: research
Protective effect of crocin against apoptosis induced by subchronic exposure of the rat vascular system to diazinon
In this study, the effect of crocin on DZN-induced apoptosis in rat vascular system was investigated. The rats were divided into 7 groups: corn oil (control), DZN (15 mg/kg/day, gavage), crocin (12.5, 25, and 50 mg/kg/day, intraperitoneally (i.p.)) + DZN, vitamin E (200 IU/kg, i.p., 3 days a week) + DZN, and crocin (50 mg/kg/day, i.p.). The treatments were continued for 4 weeks. Levels of apoptotic (Bax, caspase 3, and caspase 9) and antiapoptotic proteins (Bcl2) were analyzed by Western blotting. Transcript levels of Bax and Bcl2 genes were determined using quantitative real-time polymerase chain reaction. Results showed ...
Source: Toxicology and Industrial Health - June 26, 2016 Category: Toxicology Authors: Razavi, B. M., Hosseinzadeh, H., Abnous, K., Khoei, A., Imenshahidi, M. Tags: Articles Source Type: research
Methanolic extract of Woodfordia fruticosa Kurz flowers ameliorates carbon tetrachloride-induced chronic hepatic fibrosis in rats
Hepatic fibrosis, characterized by extracellular matrix accumulation, is the common cause of chronic liver failure and is a leading cause of morbidity and mortality worldwide. The aim of the present study was to evaluate the effect of dried flowers of Woodfordia fruticosa on carbon tetrachloride (CCl4)-induced hepatic fibrosis in rat model. Hepatic fibrosis was induced in male Wistar rats by CCl4 administration (150 μl/100 g rat weight, oral) twice a week for 10 weeks. In preventive model, administration of daily doses of methanolic extract of W. fruticosa (MEWF) at two different doses (100 mg/kg, body weight (b.w.) and...
Source: Toxicology and Industrial Health - June 26, 2016 Category: Toxicology Authors: Nitha, A., Prabha, S., Ansil, P., Latha, M. Tags: Articles Source Type: research
Determining mercury levels in anchovy and in individuals with different fish consumption habits, together with their neurological effects
An increase in enviromental pollution may lead to mercury toxicity of fish origin due to the accumulative nature of methylmercury in fish. The main sources of human exposure to organic mercury compounds are contaminated fish and other seafoods. This descriptive study was planned to determine mercury levels in anchovy and in hair samples from individuals with different fish consumption habits, and to evaluate those individuals in terms of toxic effects. For that purpose, we analyzed 100 anchovies from the Black Sea and 100 anchovies from the Sea of Marmara, and assessed 25 wholesale workers in fish markets and 25 cleaning f...
Source: Toxicology and Industrial Health - June 26, 2016 Category: Toxicology Authors: Camur, D., Güler, C., Vaizoglu, S. A., Özdilek, B. Tags: Articles Source Type: research
Biomonitoring of heavy metals using bottom fish and crab as bioindicator species, the Arvand River
The main aim of this study was to biomonitor mercury (Hg), arsenic (As), cadmium (Cd), lead (Pb) and copper (Cu) concentrations in the Arvand River using Heteropnestis fossilis and Parasesarma persicum. Comparison of heavy metals among the stations indicated that the concentrations of Hg, As, Cd, Cu and Pb in sediment samples were apparently different among the stations. The results of linear regression analyses showed that there were significant correlations (p < 0.05) between Hg, As and Pb elements in sediment and hepatopancreas of P. persicum and between As in sediment and liver of H. fossilis. These findings showed ...
Source: Toxicology and Industrial Health - June 26, 2016 Category: Toxicology Authors: Rahmanpour, S., Ashtiyani, S. M. L., Ghorghani, N. F. Tags: Articles Source Type: research
The effect of ingested sulfite on visual evoked potentials, lipid peroxidation, and antioxidant status of brain in normal and sulfite oxidase-deficient aged rats
Sulfite, commonly used as a preservative in foods, beverages, and pharmaceuticals, is a very reactive and potentially toxic molecule which is detoxified by sulfite oxidase (SOX). Changes induced by aging may be exacerbated by exogenous chemicals like sulfite. The aim of this study was to investigate the effects of ingested sulfite on visual evoked potentials (VEPs) and brain antioxidant statuses by measuring superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) activities. Brain lipid oxidation status was also determined via thiobarbituric acid reactive substances (TBARS) in normal- and SOX-deficient...
Source: Toxicology and Industrial Health - June 26, 2016 Category: Toxicology Authors: Ozsoy, O., Aras, S., Ozkan, A., Parlak, H., Aslan, M., Yargicoglu, P., Agar, A. Tags: Articles Source Type: research
Ameliorative effect of vitamin E to mouse dams and their pups following exposure of mothers to chlorpyrifos during gestation and lactation periods
In conclusion, a dietary exposure of mice during gestation and lactation to low dose of CPF led to significant changes in the mother but also in the weaned animals that have not been directly exposed to this pesticide. These biological and histological modifications could be reversed by an oral supplementation of vit. E. (Source: Toxicology and Industrial Health)
Source: Toxicology and Industrial Health - June 26, 2016 Category: Toxicology Authors: Mansour, S. A.-K., Gamet-Payrastre, L. Tags: Articles Source Type: research
Organellar proteome analyses of ricin toxin-treated HeLa cells
Apoptosis triggered by ricin toxin (RT) has previously been associated with certain cellular organellar compartments, but the diversity in the composition of the organellar proteins remains unclear. Here, we applied a shotgun proteomics strategy to examine the differential expression of proteins in the mitochondria, nuclei, and cytoplasm of HeLa cells treated and not treated with RT. Data were combined with a global bioinformatics analysis and experimental confirmations. A total of 3107 proteins were identified. Bioinformatics predictors (Proteome Analyst, WoLF PSORT, TargetP, MitoPred, Nucleo, MultiLoc, and k-nearest neig...
Source: Toxicology and Industrial Health - June 26, 2016 Category: Toxicology Authors: Liao, P., Li, Y., Li, H., Liu, W. Tags: Articles Source Type: research
Effect of monocrotophos, an organophosphorus insecticide, on the striatal dopaminergic system in a mouse model of Parkinsons disease
Our earlier study had shown that low concentrations of monocrotophos (MCP) elicited dopaminergic features of Parkinson’s disease (PD) in the nematode Caenorhabditis elegans. In the present study, the effect of low doses of MCP on the striatal dopaminergic neurons was investigated using the mouse model system. MCP was initially screened for its ability to cause any neurobehavioral deficits and alterations in the dopaminergic system in Swiss albino mice, aged 8 weeks and weighing 25–30 g, with repeated doses at 0.3 and 0.6 mg/kg body weight (b.w.)/day for 7 days and 30 days. Mice were treated with four intraperit...
Source: Toxicology and Industrial Health - June 26, 2016 Category: Toxicology Authors: Ali, S. J., Rajini, P. S. Tags: Articles Source Type: research
