Comet assay with gill cells of Mytilus galloprovincialis end point tools for biomonitoring of water antibiotic contamination: Biological treatment is a reliable process for detoxification
This article investigates the ability of Pseudomonas peli to treat industrial pharmaceuticals wastewater (PW). Liquid chromatography–mass spectrometry (MS)/MS analysis revealed the presence, in this PW, of a variety of antibiotics such as sulfathiazole, sulfamoxole, norfloxacine, cloxacilline, doxycycline, and cefquinome. P. peli was very effective to be grown in PW and inducts a remarkable increase in chemical oxygen demand and biochemical oxygen demand (140.31 and 148.51%, respectively). On the other hand, genotoxicity of the studied effluent, before and after 24 h of shaking incubation with P. peli, was evaluated ...
Source: Toxicology and Industrial Health - March 30, 2016 Category: Toxicology Authors: Mustapha, N., Zouiten, A., Dridi, D., Tahrani, L., Zouiten, D., Mosrati, R., Cherif, A., Chekir-Ghedira, L., Mansour, H. B. Tags: Articles Source Type: research
Antispasmodic and antidiarrheal activities of rhizomes of Polygonatum verticillatum maneuvered predominately through activation of K+ channels: Components identification through TLC
This study provided a pharmacological basis for the medicinal use of PR in abdominal colic and diarrhea. (Source: Toxicology and Industrial Health)
Source: Toxicology and Industrial Health - March 30, 2016 Category: Toxicology Authors: Khan, H., Saeed, M., Gilani, A.-H., Muhammad, N., ur Rehman, N., Mehmood, M. H., Ashraf, N. Tags: Articles Source Type: research
Alterations in the fatty acid profile, antioxidant enzymes and protein pattern of Biomphalaria alexandrina snails exposed to the pesticides diazinon and profenfos
The use of pesticides is widespread in agricultural activities. These pesticides may contaminate the irrigation and drainage systems during agriculture activities and pests’ control and then negatively affect the biotic and a biotic component of the polluted water courses. The present study aimed to evaluate the effect of the pesticides diazinon and profenfos on some biological activities of Biomphalaria alexandrina snails such as fatty acid profile, some antioxidant enzymes (thioredoxin reductase (TrxR), sorbitol dehydrogenase (SDH), superoxide dismutase (SOD), catalase (CAT) as well as glutathione reductase (GR) an...
Source: Toxicology and Industrial Health - March 30, 2016 Category: Toxicology Authors: Bakry, F. A., El-Hommossany, K., Abd El-Atti, M., Ismail, S. M. Tags: Articles Source Type: research
The endocrine disruptor effect of the herbicides atrazine and glyphosate on Biomphalaria alexandrina snails
Atrazine (AZ) and glyphosate (GL) are herbicides that are widely applied to cereal crops in Egypt. The present study was designed to investigate the response of the snail Biomphalaria alexandrina (Mollusca: Gastropoda) as a bioindicator for endocrine disrupters in terms of steroid levels (testosterone (T) and 17β-estradiol (E)), alteration of microsomal CYP4501B1-like immunoreactivity, total protein (TP) level, and gonadal structure after exposure to sublethal concentrations of AZ or GL for 3 weeks. In order to study the ability of the snails’ recuperation, the exposed snails were subjected to a recovery period ...
Source: Toxicology and Industrial Health - March 30, 2016 Category: Toxicology Authors: Omran, N. E., Salama, W. M. Tags: Articles Source Type: research
Studies on fate and toxicity of nanoalumina in male albino rats: Some haematological, biochemical and histological aspects
The work aimed to evaluate the nanoalumina toxicity on the histological architecture, some haematological and biochemical aspects in male albino rats, during acute and sublethal experiments. Rats, in acute experiments, were injected with a single-acute dose of 3.9 g or 6.4 g or 8.5 g of aluminium oxide (Al2O3) kg– 1, whereas those of sublethal were injected with 1.3 g of Al2O3 kg– 1 2 days– 1. One-way analysis of variance indicated that injected doses and the experimental periods were significantly affected by haemoglobin (Hb) content; haematocrit value (Hct); white blood cell (WBC) count; blood platel...
Source: Toxicology and Industrial Health - March 30, 2016 Category: Toxicology Authors: Morsy, G. M., El-Ala, K. S. A., Ali, A. A. Tags: Articles Source Type: research
Investigation of cytotoxic, genotoxic and oxidative properties of carvacrol in human blood cells
In conclusion, CVC can be a new resource of therapeutics as recognized in this study with their nonmutagenic and antioxidant features. (Source: Toxicology and Industrial Health)
Source: Toxicology and Industrial Health - March 30, 2016 Category: Toxicology Authors: Türkez, H., Aydın, E. Tags: Articles Source Type: research
Comparative impact of genetically modified and non modified maize (Zea mays L.) on succeeding crop and associated weed
This research work documents the comparative impact of genetically modified (GM) (insect resistance) and non modified maize (Zea mays L.) on growth and germination of succeeding crop wheat (Triticum aestivum L.) and associated weed (Avena fatua L.). The aqueous extracts of both the GM and non-GM maize exhibited higher phenolic content than that of methanolic extracts. Germination percentage and germination index of wheat was significantly decreased by GM methanolic extract (10%) as well as that of non-GM maize at 3% aqueous extract. Similarly germination percentage of weed (Avena fatua L.) was significantly reduced by appl...
Source: Toxicology and Industrial Health - March 30, 2016 Category: Toxicology Authors: Ibrahim, M., Ahmed, N., Ullah, F., Shinwari, Z. K., Bano, A. Tags: Articles Source Type: research
The biochemical and histological effects of lichens in normal and diabetic rats
This study covers a previously unrecognized effect of two well-known lichen species Cetraria islandica and Pseudevernia furfuracae in streptozotocin (STZ)-induced diabetes. In experimental design, control or diabetic rats were either untreated or treated with aqueous lichen extracts (250–500 mg/kg /day) for 2 weeks starting at 72 h after STZ injection. On day 14, animals were anaesthetized, and metabolic and biochemical parameters were appreciated between control and treatment groups. The histopathology of liver was examined using three different staining methods: hematoxylin–eosin (H&E), periodic acid Schi...
Source: Toxicology and Industrial Health - March 30, 2016 Category: Toxicology Authors: Deniz, G. Y., Geyikoglu, F., Türkez, H., Bakır, T. O., Colak, S., Aslan, A. Tags: Articles Source Type: research
Protective effects of silymarin against acetaminophen-induced hepatotoxicity and nephrotoxicity in mice
This study was designed to estimate protective effects of silymarin on acetaminophen (N-acetyl-p-aminophenol, paracetamol; APAP)-induced hepatotoxicity and nephrotoxicity in mice. Treatment of mice with overdose of APAP resulted in the elevation of aspartate aminotransferase (AST), alanine transaminase (ALT), blood urea nitrogen (BUN), and serum creatinine (SCr) levels in serum, liver, and kidney nitric oxide (NO) levels and significant histological changes including decreased body weight, swelling of hepatocytes, cell infiltration, dilatation and congestion, necrosis and apoptosis in liver, and dilatation of Bowman’...
Source: Toxicology and Industrial Health - March 30, 2016 Category: Toxicology Authors: Bektur, N. E., Sahin, E., Baycu, C., Unver, G. Tags: Articles Source Type: research
Exposure of rat hippocampal astrocytes to Ziram increases oxidative stress
Pesticides have been shown in several studies to be the leading candidates of environmental toxins and may contribute to the pathogenesis of several neurodegenerative diseases. Ziram (zinc-bis(dimethyldithiocarbamate)) is an agricultural dithiocarbamate fungicide that is used to treat a variety of plant diseases. In spite of their generally acknowledged low toxicity, dithiocarbamates are known to cause a wide range of neurobehavioral effects as well as neuropathological changes in the brain. Astrocytes play a key role in normal brain physiology and in the pathology of the nervous system. This investigation studied the effe...
Source: Toxicology and Industrial Health - March 30, 2016 Category: Toxicology Authors: Matei, A.-M., Trombetta, L. D. Tags: Articles Source Type: research
Reviewer List
(Source: Toxicology and Industrial Health)
Source: Toxicology and Industrial Health - March 3, 2016 Category: Toxicology Tags: Articles Source Type: research
Allelopathic effect of methanolic extracts of genetically modified and non-genetically modified canola on soybean
This study on the effect of genetically modified (GM) and non-GM canola on soybean was carried out for physiological and biochemical biosafety assessment of GM canola. Methanolic extracts of GM and non-GM canola were assessed on seed germination and growth of soybean (Glycine max L.) under sterilized conditions. The extracts applied were of 3, 5, and 10% concentrations. The results showed that methanolic extracts of both GM and non-GM canola improved the germination percentage. However, germination rate index was significantly decreased with concomitant increase in mean germination time of soybean. A significant rate of de...
Source: Toxicology and Industrial Health - March 3, 2016 Category: Toxicology Authors: Syed, K., Shinwari, Z. K. Tags: Articles Source Type: research
Physiological biosafety assessment of genetically modified canola on weed (Avena sativa)
The present study was carried out for the assessment of physiological biosafety and effects of genetically modified (GM) canola on Avena sativa, which is a common weed plant of South Asia. Methanolic extracts of GM and non-GM canola were assessed on seed germination and growth of A. sativa under sterilized conditions. The extracts were treated with 3%, 5%, and 10% concentrations of methanol. Results showed that the extract of GM canola increases the number of roots and root fresh weight. However, root length was significantly decreased. Similarly, a significant rate of increase was observed in shoot fresh weight and shoot ...
Source: Toxicology and Industrial Health - March 3, 2016 Category: Toxicology Authors: Syed, K., Shinwari, Z. K. Tags: Articles Source Type: research
Protective effects of onion (Allium cepa) extract against doxorubicin-induced hepatotoxicity in rats
Conclusion:
Our study indicates that pretreatment with ACE protects against DOX-induced hepatotoxicity due to the antioxidant properties of ACE. Further studies on efficacy of antioxidant treatment by ACE in DOX-mediated toxicity and underlying mechanisms would provide a better explanation. (Source: Toxicology and Industrial Health)
Source: Toxicology and Industrial Health - March 3, 2016 Category: Toxicology Authors: Mete, R., Oran, M., Topcu, B., Oznur, M., Seber, E. S., Gedikbasi, A., Yetisyigit, T. Tags: Articles Source Type: research
Neuroprotective effect of quercetin against oxidative damage and neuronal apoptosis caused by cadmium in hippocampus
The purpose of the present investigation was to evaluate cadmium (Cd)-induced neurotoxicity in hippocampal tissues and beneficial effect of quercetin (QE) against neuronal damage. A total of 30 male rats were divided into 3 groups: control, Cd-treated, and Cd + QE-treated groups. After the treatment, the animals were killed and hippocampal tissues were removed for biochemical and histopathological investigation. Cd significantly increased tissue malondialdehyde (MDA) and protein carbonyl (PC) levels and also decreased superoxide dismutase (SOD) and catalase (CAT) enzyme activities in hippocampal tissue compared with the co...
Source: Toxicology and Industrial Health - March 3, 2016 Category: Toxicology Authors: Kanter, M., Unsal, C., Aktas, C., Erboga, M. Tags: Articles Source Type: research
