Comparative toxicity of Paraquat herbicide and some plant extracts in Lymnaea natalensis snails
Paraquat has been shown to be a highly toxic compound for humans and animals, and many cases of acute poisoning and death have been reported over the past few decades. The present study was undertaken to evaluate comprehensively herbicides (Paraquat) and some plant extracts to biochemical aspects of Lymnaea natalensis snails. It was found that the exposure of L. natalensis to Paraquat and plant extracts led to a significant reduction in the infectivity of Fasciola gigantica miracidia to the snail. The glucose level in hemolymph of exposed snails was elevated, while the glycogen showed a decrease in soft tissues when compar...
Source: Toxicology and Industrial Health - December 31, 2015 Category: Toxicology Authors: Bakry, F. A., Eleiwa, M. E., Taha, S. A., Ismil, S. M. Tags: Articles Source Type: research
Antioxidant profile of constituents isolated from Polygonatum verticillatum rhizomes
In conclusion, both the isolated compounds have strong antioxidant potential, which is consistent with the results of the extracts of the plant. (Source: Toxicology and Industrial Health)
Source: Toxicology and Industrial Health - December 31, 2015 Category: Toxicology Authors: Khan, H., Saeed, M., Muhammad, N., Rauf, A., Khan, A. Z., Ullah, R. Tags: Articles Source Type: research
Ameliorating effect of pomegranate juice consumption on carbon tetrachloride-induced sperm damages, lipid peroxidation, and testicular apoptosis
In conclusion, PJ consumption ameliorates the CCl4-induced damages in male reproductive organs and cells by decreasing the lipid peroxidation. (Source: Toxicology and Industrial Health)
Source: Toxicology and Industrial Health - December 31, 2015 Category: Toxicology Authors: Türk, G., Ceribası, S., Sönmez, M., Ciftci, M., Yüce, A., Güvenc, M., Kaya, S. O., Cay, M., Aksakal, M. Tags: Articles Source Type: research
Prenatal developmental toxicity study of n-heneicosane in Wistar rats
n-Heneicosane (C21) is one of the vital pheromone for attracting mosquitoes of Aedes spp to lay their eggs in areas of stagnant fresh water, for their subsequent destruction, thus controlling spread of dangerous disease transmission by the vectors. As part of a safety evaluation, we have investigated embryo toxic and teratogenic potential, if any, of C21 following OECD Test Guideline 414. C21 was offered at a dose of 1 g/kg body weight mixed in the standard rat pellet diet to treated rats, whereas the control group received only standard rat pellet diet. There were no mortalities and animals did not show any clinical ...
Source: Toxicology and Industrial Health - December 31, 2015 Category: Toxicology Authors: Kumar, P., Lomash, V., Jatav, P., Kumar, A., Pant, S. Tags: Articles Source Type: research
The effects of resveratrol against trifluralin toxicity in the urinary tract of rats
The herbicide itself and the degradation products are highly toxic on biological systems. The aim of this study is to investigate the potential toxic effects of trifluralin (TRF) on the urinary system of male rats and to investigate the protective effects of resveratrol (RSV) in TRF-induced urinary system damage. A total of 35 male Wistar rats were randomly divided into: (1) control group, (2) sham group, (3) low dose TRF group (0.8 g/kg/day), (4) high dose TRF group (2 g/kg/day) and (5) high dose TRF + RSV group 10 mg/kg/day. RSV was administered for 21 days by intragastric gavage at a dose of 10 mg/kg...
Source: Toxicology and Industrial Health - December 31, 2015 Category: Toxicology Authors: Denek, Z., Erbil, G., Ozbal, S., Micili, S. C., Ozogul, C. Tags: Articles Source Type: research
Free radical scavenging activity in in vitro-derived tissues of Eruca sativa
Feasible regeneration protocol for economically important plant Eruca sativa was established and 1, 1-diphenyl-2-picrylhydrazyl scavenging activity of regenerated tissues was evaluated and compared with plant material collected from the wild. Leaf portions inoculated onto Murashige and Skoog (MS) medium responded to all plant growth regulators exploited. Optimum callus production was achieved on a combination of 2.0 mg l–1 6-benzyladenine (BA) + 1.0 mg l–1 α-naphthalene acetic acid (NAA) and the lowest response was recorded for 0.5 mg l–1 gibberellic acid (GA3)&nbs...
Source: Toxicology and Industrial Health - December 31, 2015 Category: Toxicology Authors: Abbasi, B. H., Ali, J., Ali, M., Zia, M., Bokhari, S. A., Khan, M. A. Tags: Articles Source Type: research
Effects of antioxidants on drugs used against testicular cancer-induced alterations in metastasis-associated protein 1 signaling in the rat testis
In conclusion, the results indicate that both BEP and AO suppress MTA1 and MTA1s transcription, which may render the germ cells to be more prone to apoptosis. However, upregulation of MTA1 protein expression may be related to induced DNA damage. Modulation of MTA1 signaling is a novel mechanism of action of BEP and AO, which may be useful in developing newer anticancer drugs. (Source: Toxicology and Industrial Health)
Source: Toxicology and Industrial Health - December 31, 2015 Category: Toxicology Authors: Kilarkaje, N., Al-Bader, M. Tags: Articles Source Type: research
Chelation of thallium by combining deferasirox and desferrioxamine in rats
The hypothesis that two known chelators deferasirox (4-[3,5-bis(2-hydroxyphenyl)-1,2,4-triazol-1-yl]-benzoic acid) and desferrioxamine (DFO) might be more efficient as combined treatment than as monotherapies in removing thallium from the body was tested in a new acute rat model. 7-week-old male Wistar rats received chelators: deferasirox (orally), DFO (intraperitoneal; i.p.), or deferasirox + DFO as 75 or 150 mg/kg dose half an hour after a single i.p. administration of 8 mg thallium/kg body weight in the form of chloride. Serum thallium concentration, urinary thallium, and iron excretions were determined by graphite furn...
Source: Toxicology and Industrial Health - December 31, 2015 Category: Toxicology Authors: Saljooghi, A. S., Babaie, M., Mendi, F. D., Zahmati, M., Saljooghi, Z. S. Tags: Articles Source Type: research
Effects of electromagnetic field exposure on the heart: a systematic review
The use of electrical devices has gradually increased throughout the last century, and scientists have suggested that electromagnetic fields (EMF) generated by such devices may have harmful effects on living creatures. This work represents a systematic review of collective scholarly literature examining the effects of EMFs on the heart. Although most works describing effects of EMF exposure have been carried out using city electric frequencies (50–60 Hz), a consensus has not been reached about whether long- or short-term exposure to 50–60 Hz EMF negatively affects the heart. Studies have indicated that EMFs pro...
Source: Toxicology and Industrial Health - December 31, 2015 Category: Toxicology Authors: Elmas, O. Tags: Articles Source Type: research
Effect of grapefruit juice on amiodarone induced nephrotoxicity in albino rats
Amiodarone is a potent antiarrhythmic drug that is used to treat ventricular and supraventricular tachyarrhythmias. The present work studied the effect of amiodarone on the kidney of albino rats and the possible ameliorative role of grapefruit juice. Administration of amiodarone by gastric intubation (18 mg/kg body weight (b.w.), daily for 5 weeks) caused many histological alterations including intertubular leucocytic infiltrations, degeneration of the renal tubules, and atrophy of the glomeruli. Amiodarone caused marked elevation in serum creatinine and blood urea nitrogen. Histochemical examination of the renal tubules r...
Source: Toxicology and Industrial Health - December 31, 2015 Category: Toxicology Authors: Sakr, S. A., El-Gamal, E. M. Tags: Articles Source Type: research
Dimethyl dimethoxy biphenyl dicarboxylate attenuates hepatic and metabolic alterations in high fructose-fed rats
In conclusion, DDB ameliorates high fructose-induced metabolic disorders and hepatic steatosis in rats. Such protection is, at least in part, due to the inhibition of lipid peroxidation, decrease in iNOS overexpression, and reduction of elevated uric acid. (Source: Toxicology and Industrial Health)
Source: Toxicology and Industrial Health - December 31, 2015 Category: Toxicology Authors: Morsy, M. A., Ibrahim, M. A., Abd-Elghany, M. I. Tags: Articles Source Type: research
Chemoprotective effect of Vernonia amygdalina Del. (Astereacea) against 2-acetylaminofluorene-induced hepatotoxicity in rats
This study investigated the chemoprotective properties of methanolic extract of Vernonia amygdalina (MEVA) in an experimental model of hepatic oxidative damage induced by 2-acetylaminofluorene (2-AAF). Rats were divided into six groups. Groups 1 and 2 received saline and dimethyl sulfoxide, respectively, and served as controls. Group 3 received MEVA at a dose of 250 mg/kg, while groups 5 and 6 were pretreated for 14 days with MEVA at 250 mg/kg and 500 mg/kg doses before coadministration with 2-AAF at 100 mg/kg for another 7 days. 2-AAF was administered to group 4 for the last 7 days. Anim...
Source: Toxicology and Industrial Health - December 31, 2015 Category: Toxicology Authors: Adesanoye, O. A., Adekunle, A. E., Adewale, O. B., Mbagwu, A. E., Delima, A. A., Adefegha, S. A., Molehin, O. R., Farombi, E. O. Tags: Articles Source Type: research
Effects of administration of subtoxic doses of acetaminophen on liver and blood levels of insulin-like growth factor-1 in rats
In conclusion, these results suggest that blood IGF-1 levels may have a value in predicting hepatic damage resulting from therapeutic doses of APAP. (Source: Toxicology and Industrial Health)
Source: Toxicology and Industrial Health - December 31, 2015 Category: Toxicology Authors: Ozdemir, D., Aksu, I., Baykara, B., Ates, M., Sisman, A. R., Kiray, M., Buyuk, A., Uysal, N. Tags: Articles Source Type: research
Biological studies on the effect of estrogen on experimentally induced asthma in mice
In conclusion, the obtained results indicated that the asthma is responsible for certain immunohistochemical and physiological alterations induced in lung tissues of mice. The administration of estrogen to asthmatic male mice could improve these changes. For this reason, the present findings support the possible role of estrogen in modulating the inflammatory effects caused by asthma in male mice and may be helpful to cure many asthmatic progressions. (Source: Toxicology and Industrial Health)
Source: Toxicology and Industrial Health - December 31, 2015 Category: Toxicology Authors: El-Desouki, N. I., Tabl, G. A., Elkhodary, Y. A. Tags: Articles Source Type: research
Evidence of elevated levels of polychlorinated biphenyl congeners in commonly consumed fish from Eleyele Reservoir, Southwestern Nigeria
Environmental pollution of water, which is a source of cheap and affordable protein in the form of fish on which the population depends on, is of great concern globally. The present study assesses the levels of polychlorinated biphenyls (PCBs) congeners in sediments and six commonly consumed cichlid species from Eleyele Reservoir, Southwestern Nigeria. The results indicate that the concentrations of heavier PCB congeners are higher than the lighter congeners in both sediment and fish tissue. The predominant PCB congeners in the sediment samples from this site were PCBs 8, 44, 114, 101, 189, 196, 206 and 209. The concentrat...
Source: Toxicology and Industrial Health - December 31, 2015 Category: Toxicology Authors: Adeogun, A. O., Adedara, I. A., Farombi, E. O. Tags: Articles Source Type: research
