Ameliorative effect of lycopene against 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced rat liver microsomal toxicity: An in vitro study

In conclusion, the findings of the study indicate that TCDD induces a significant oxidative stress in liver microsomes as manifested by increased LPO, H2O2 production, protein carbonyl content and activities of UDPGT and P450 and decreased antioxidant enzymes activities and thiol content. By the reversal of biochemical and oxidative markers toward normalcy, the protective role of lycopene is illuminated in rat liver microsomal toxicity.

Source: Toxicology and Industrial Health - September 25, 2015 Category: Toxicology Authors: Aly, H. A., El-Shitany, N. A., El-Beshbishy, H. A., Ashour, O. M. Tags: Articles Source Type: research