DBA-induced caspase-3-dependent apoptosis occurs through mitochondrial translocation of cyt-c in the rat hippocampus
Mol. BioSyst., 2017, Advance Article DOI: 10.1039/C7MB00246G, PaperWenbo Jiang, Yingying Chen, Bai Li, Shuying Gao The present study investigated the neurotoxicity of DBA by assessing the behavioral and biochemical characteristics in the rat hippocampus, and the mechanism isvia caspase-3-dependent apoptosis involving mitochondrial translocation of cyt-c. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - July 21, 2017 Category: Molecular Biology Authors: Wenbo Jiang Source Type: research
MALDI MS imaging investigation of host response to visceral leishmaniasis
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00306D, PaperCarol Jaegger Franco, Fernanda Negrao, Diego Assis, Katia Roberta A. Belaz, Celio Fernando Figueiredo Angolini, Anna Maria Fernandes, Vanessa G. Santos, Alessandra Pimentel, Daniel Ruiz Abanades, Selma Giorgio, Marcos N Eberlin, Daniele Fernanda de Oliveira Rocha Mass Spectrometry Imaging (MSI) of animal tissues has become an important tool for in situ molecular analyses and biomarker studies in several clinical areas, but there are few applications in... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - July 20, 2017 Category: Molecular Biology Authors: Carol Jaegger Franco Source Type: research
Peculiarities of thermal denaturation of OmpF porin from Yersinia ruckeri
Mol. BioSyst., 2017, Advance Article DOI: 10.1039/C7MB00239D, PaperOlga D. Novikova, Dmitry K. Chistyulin, Valentina A. Khomenko, Evgeny V. Sidorin, Natalya Yu. Kim, Nina M. Sanina, Olga Yu. Portnyagina, Tamara F. Solov'eva, Vladimir N. Uversky, Valery L. Shnyrov Irreversible denaturation of membrane proteins in detergent solutions is similar to unfolding of water-soluble multidomain proteins and represents a complex, multistage process. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - July 20, 2017 Category: Molecular Biology Authors: Olga D. Novikova Source Type: research
Protein intrinsic disorder negatively associates with gene age in different eukaryotic lineages
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00230K, PaperSanghita Banerjee, Sandip Chakraborty Emergence of new protein-coding genes in a specific lineage or species provides raw materials for evolutionary adaptations. Until recently, the biology of new genes emerging particularly from non-genic sequences remains... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - July 18, 2017 Category: Molecular Biology Authors: Sanghita Banerjee Source Type: research
Coarse-grained Simulations of Conformational Changes in Multidrug Efflux Transporter AcrB
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00276A, PaperYead Jewel, Jin Liu, Prashanta Dutta The multidrug resistance (MDR) system actively pumps the antibiotics out of cells causing serious health problems. During the pumping, AcrB (one of the key MDR components), undergoes a series of... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - July 17, 2017 Category: Molecular Biology Authors: Yead Jewel Source Type: research
Insights into the Giardia intestinalis Enolase and Human Plasminogen interaction
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00252A, PaperRodrigo Aguayo-Ortiz, Patricia Meza-Cervantez, Rafel Castillo, Alicia Hernandez-Campos, Laura Dominguez, Lilian Yepez-Mulia Giardia intestinalis is an intestinal parasite that causes diarrhea in humans and animals worldwide. The enolase of G. intestinalis (GiENO) participates in its glycolysis pathway and is abundantly expressed in... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - July 17, 2017 Category: Molecular Biology Authors: Rodrigo Aguayo-Ortiz Source Type: research
The antiproliferative activity of di-2-pyridylketone dithiocarbamate is partly attributed to catalase inhibition: detailing the interaction by spectroscopic methods
Mol. BioSyst., 2017, Advance Article DOI: 10.1039/C7MB00032D, PaperCuiping Li, Youxun Liu, Yun Fu, Tengfei Huang, Lixia Kang, Changzheng Li The bioactivity of drugs is attributed to their interaction with biological molecules, embodied in either their direct or indirect influence on enzyme activity and conformation. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - July 17, 2017 Category: Molecular Biology Authors: Cuiping Li Source Type: research
A comparative review of computational methods for pathway perturbation analysis: dynamical and topological perspectives
Mol. BioSyst., 2017, Advance Article DOI: 10.1039/C7MB00170C, Review ArticleQ. Vanhaelen, A. M. Aliper, A. Zhavoronkov Stem cells offer great promise within the field of regenerative medicine but despite encouraging results, the large scale use of stem cells for therapeutic applications still faces challenges when it comes to controlling signaling pathway responses with respect to environmental perturbations. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - July 17, 2017 Category: Molecular Biology Authors: Q. Vanhaelen Source Type: research
Systems-level organization of non-alcoholic fatty liver disease progression network
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00013H, PaperKumar Shubham, Lanke Vinay, P K Vinod Non-Alcoholic Fatty Liver Disease (NAFLD) is a complex spectrum of diseases ranging from simple steatosis to Non-Alcoholic Steatohepatitis (NASH) with fibrosis, which can progress to cirrhosis and hepatocellular carcinoma. The... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - July 15, 2017 Category: Molecular Biology Authors: Kumar Shubham Source Type: research
Global DNA dynamics of 8-oxoguanine repair by human OGG1 revealed by stopped-flow kinetics and molecular dynamic simulation
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00343A, PaperMaria V. Lukina, Vladimir V. Koval, Alexander A. Lomzov, Dmitry O. Zharkov, Olga S. Fedorova Toxic action of different endogenous and exogenous agents leads to damages in the genomic DNA. 8-Oxoguanine is one of the mostly often generated and highly mutagenic oxidative damage in DNA.... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - July 15, 2017 Category: Molecular Biology Authors: Maria V. Lukina Source Type: research
Functional aqueous droplet networks
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00192D, Review ArticleMichael Booth, Vanessa Restrepo Schild, Florence Downs, Hagan Bayley Droplet interface bilayers (DIBs), comprising individual lipid bilayers between pairs of aqueous droplets in an oil, are proving to be a useful tool for studying membrane proteins. Recently, attention has... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - July 13, 2017 Category: Molecular Biology Authors: Michael Booth Source Type: research
Structural switch from a multistranded G-quadruplex to single strands as a consequence of point mutation in the promoter of the human GRIN1 gene
Mol. BioSyst., 2017, Advance Article DOI: 10.1039/C7MB00360A, PaperSwati Chaudhary, Mahima Kaushik, Ritushree Kukreti, Shrikant Kukreti Formation of a multistranded G-quadruplex in a sequence with point mutation in the promoter of the humanGRIN1 gene associated with schizophrenia. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - July 13, 2017 Category: Molecular Biology Authors: Swati Chaudhary Source Type: research
Identifying the common genetic networks of ADR (adverse drug reaction) clusters and developing an ADR classification model
Mol. BioSyst., 2017, Advance Article DOI: 10.1039/C7MB00059F, PaperYouhyeon Hwang, Min Oh, Giup Jang, Taekeon Lee, Chihyun Park, Jaegyoon Ahn, Youngmi Yoon We propose a computational method that elucidates the action mechanisms of ADRs and predicts potential ADRs by utilizing ADR genes, drug features, and protein-protein interaction (PPI) networks. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - July 12, 2017 Category: Molecular Biology Authors: Youhyeon Hwang Source Type: research
LPI-ETSLP: lncRNA-protein interaction prediction using eigenvalue transformation-based semi-supervised link prediction
Mol. BioSyst., 2017, Advance Article DOI: 10.1039/C7MB00290D, PaperHuan Hu, Chunyu Zhu, Haixin Ai, Li Zhang, Jian Zhao, Qi Zhao, Hongsheng Liu RNA-protein interactions are essential for understanding many important cellular processes. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - July 12, 2017 Category: Molecular Biology Authors: Huan Hu Source Type: research
Identification of perturbed signaling pathways from gene expression data using information divergence
Mol. BioSyst., 2017, Advance Article DOI: 10.1039/C7MB00285H, PaperXinying Hu, Hang Wei, Haoran Zheng We propose a pathway analysis method based on information divergence and the probability distribution of the regulation capacity. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - July 12, 2017 Category: Molecular Biology Authors: Xinying Hu Source Type: research
