Structural switch from multistranded G-quadruplex to single strands as a consequence of point mutation in the promoter of human GRIN1 gene
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00360A, PaperSWATI CHAUDHARY, Mahima Kaushik, Ritushree Kukreti, Shrikant Kukreti A huge number of G-rich sequences forming quadruplexes are found in human genome, especially on telomeric regions, UTR's, and promoter regions of a number of genes. One such gene is... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - June 30, 2017 Category: Molecular Biology Authors: SWATI CHAUDHARY Source Type: research
Hydrogen sulfide donor micelles protect cardiomyocytes from ischemic cell death
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00191F, CommunicationTomoka Takatani-Nakase, Miku Katayama, Chihiro Matsui, Kenjiro Hanaoka, Andre J. van der Vlies, Koichi Takahashi, Ikuhiko Nakase, Urara Hasegawa Hydogen sulfide, an important gaseous signaling molecule in the human body, is known to protect cardiomyocytes from ischemia, a condition characterized by insufficient oxygen supply to the cells. Here we... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - June 28, 2017 Category: Molecular Biology Authors: Tomoka Takatani-Nakase Source Type: research
Molecular dynamics simulations and in vitro analysis of the CRMP2 thiol switch
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00160F, PaperDaniel Moller, Manuela Gellert, Walter Langel, Christopher Horst Lillig Collapsin response mediator protein CRMP2 (gene: DPYSL2) is crucial for neuronal development. The homotetrameric CRMP2 complex is regulated via two mechanisms, first by phosphorylation, and second by reduction and oxidation... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - June 27, 2017 Category: Molecular Biology Authors: Daniel Moller Source Type: research
Identification of Perturbed Signaling Pathway from Gene Expression Data by Using Information Divergence
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00285H, PaperXinying Hu, Hang Wei, Haoran Zheng Abnormal regulation of signaling pathways is the key causative factor in several diseases. Although many methods have been proposed to identify significantly differential pathways between two conditions via microarray gene... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - June 27, 2017 Category: Molecular Biology Authors: Xinying Hu Source Type: research
Ligand-induced conformational preorganization of loops of c-MYC G-quadruplex DNA and its implications in structure-specific drug design
Mol. BioSyst., 2017, Advance Article DOI: 10.1039/C7MB00175D, PaperS. Harikrishna, Saikiran Kotaru, P. I. Pradeepkumar Ligand binding toc-MYC G-quadruplex DNA induces conformational changes in the loops of the quadruplex.c-MYC quadruplex-specific small molecules can be designed by targeting these loop conformers. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - June 26, 2017 Category: Molecular Biology Authors: S. Harikrishna Source Type: research
Phosphorylation of a full length amyloid-[small beta] peptide modulates its amyloid aggregation, cell binding and neurotoxic properties
Mol. BioSyst., 2017, Advance Article DOI: 10.1039/C7MB00249A, PaperElaheh Jamasbi, Frances Separovic, Mohammed Akhter Hossain, Giuseppe Donato Ciccotosto Phosphorylation of A[small beta]42 promotes the formation of amyloid plaques in the brain, which lack the neurotoxic properties associated with oligomeric species causing pathogenesis in Alzheimer's disease. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - June 23, 2017 Category: Molecular Biology Authors: Elaheh Jamasbi Source Type: research
Computational analysis of histidine mutations on the structural stability of human tyrosinases leading to albinism insurgence
Mol. BioSyst., 2017, Advance Article DOI: 10.1039/C7MB00211D, PaperMubashir Hassan, Qamar Abbas, Hussain Raza, Ahmed A. Moustafa, Sung-Yum Seo Misfolding and structural alteration in proteins lead to serious malfunctions and cause various diseases in humans. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - June 22, 2017 Category: Molecular Biology Authors: Mubashir Hassan Source Type: research
Transcriptome dynamics of human pluripotent stem cell-derived contracting cardiomyocytes using an embryoid body model with fetal bovine serum
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00174F, PaperMi-Young Son, Kwang Bo Jung, Ye Seul Son, Hana Lee, Cho-Rok Jung, Janghwan Kim Cardiomyocyte (CM) differentiation techniques for generating adult-like mature CMs remain imperfect, and plausible underlying mechanisms remain unclear; however, there are a number of current protocols available. Here, to explore the... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - June 22, 2017 Category: Molecular Biology Authors: Mi-Young Son Source Type: research
LPI-ETSLP: LncRNA-protein interactions prediction using Eigenvalue Transformation-based Semi-supervised Link Prediction
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00290D, PaperHuan Hu, Chunyu Zhu, Haixin Ai, Li Zhang, Jian Zhao, Qi Zhao, Hongsheng Liu RNA-protein interactions are essential in understanding many important cellular processes. In particular, lncRNA-protein interactions play important roles in post transcriptional gene regulation, such as splicing, translation, signaling and even the... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - June 22, 2017 Category: Molecular Biology Authors: Huan Hu Source Type: research
Dissecting binding of a [small beta]-barrel membrane protein by phage display
Mol. BioSyst., 2017, Advance Article DOI: 10.1039/C7MB00163K, PaperLuz M. Meneghini, Sarvind Tripathi, Marcus A. Woodworth, Sudipta Majumdar, Thomas L. Poulos, Gregory A. Weiss Membrane proteins (MPs) contribute to a myriad of cellular functions. Phage-display of the TonB dependent transporter and MP, ShuA, allows its rapid mutagenesis for structure-function studies. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - June 19, 2017 Category: Molecular Biology Authors: Luz M. Meneghini Source Type: research
Functional roles of intrinsic disorder in CRISPR-associated protein, Cas9
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00279C, PaperZhihua Du, Vladimir N. Uversky Protein intrinsic disorder is an important characteristic commonly detected in multifunctional or RNA- and DNA-binding proteins. Due to their high conformational flexibility and solvent accessibility, intrinsically disordered proteins (IDPs) and... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - June 19, 2017 Category: Molecular Biology Authors: Zhihua Du Source Type: research
Identifying common genetic network of ADR (adverse drug reaction) clusters and developing ADR classification model
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00059F, PaperYouhyeon Hwang, Min Oh, Giup Jang, Taekeon Lee, Chihyun Park, Jaegyoon Ahn, Youngmi Yoon Adverse drug reactions (ADRs) are one of the major concerns threatening public health and have resulted in failures in drug development. Thus, predicting ADRs and discovering mechanisms underlying ADRs have... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - June 19, 2017 Category: Molecular Biology Authors: Youhyeon Hwang Source Type: research
iMulti-HumPhos: A Multi-Label Classifier for Identifying Human Phosphorylated Proteins Using Multiple Kernel Learning Based Support Vector Machine
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00180K, PaperMd. Al Mehedi Hasan, Shamim Ahmad, Md. Khademul Islam Molla Protein phosphorylation shows a potential role in regulating protein conformation and functions. As a result, identifying an uncharacterized protein sequence as phosphorylated protein is a very meaningful problem and an... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - June 16, 2017 Category: Molecular Biology Authors: Md. Al Mehedi Hasan Source Type: research
Computational investigation of the human SOD1 mutant, Cys146Arg, that directs familial amyotrophic lateral sclerosis
Mol. BioSyst., 2017, Advance Article DOI: 10.1039/C7MB00106A, PaperE. Srinivasan, R. Rajasekaran Molecular dynamics simulations along with the computational predictions used to assess the protein structural characterization as well as the conformational preferences of the monomeric native and mutant SOD1. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - June 16, 2017 Category: Molecular Biology Authors: E. Srinivasan Source Type: research
Identification of Human Flap endonuclease 1 (FEN1) inhibitors using a machine learning based consensus virtual screening
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00118E, PaperAmit Laxmikant Deshmukh, Sharat Chandra, Deependra Kumar Singh, M. I. Siddiqi, Dibyendu Banerjee Human Flap endonuclease1 (FEN1) is an enzyme that is indispensable for DNA replication and repair processes and inhibiting its Flap cleavage activity results in increased cellular sensitivity to DNA damaging... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - June 15, 2017 Category: Molecular Biology Authors: Amit Laxmikant Deshmukh Source Type: research
