Prediction of drug-pathway interaction pairs with a disease-combined LSA-PU-KNN method
Mol. BioSyst., 2017, Advance Article DOI: 10.1039/C7MB00441A, PaperFan-Shu Chen, Hui-Yan Jiang, Zhenran Jiang This paper proposes a prediction of potential associations between drugs and pathways based on a disease-related LSA-PU-KNN method. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - October 12, 2017 Category: Molecular Biology Authors: Fan-Shu Chen Source Type: research
Methods for monitoring and measurement of protein translation in time and space
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00476A, Review ArticleMaria ` Dermit, Martin Dodel, Faraz Mardakheh Regulation of protein translation constitutes a crucial step in control of gene expression. In comparison to transcriptional regulation, however, translational control has remained a significantly under-studied layer of gene expression.... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - October 12, 2017 Category: Molecular Biology Authors: Maria ` Dermit Source Type: research
Insights into human intrinsically disordered proteins from their gene expression profile
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00311K, PaperArup Panda, Debarun Acharya, Tapash Chandra Ghosh Expression level provides important clues about gene function. Previously, various efforts have been undertaken to profile human genes according to their expression level. Intrinsically disordered proteins (IDPs) do not adopt... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - October 12, 2017 Category: Molecular Biology Authors: Arup Panda Source Type: research
NARRMDA: Negative-Aware and Rating-based Recommendation algorithm for MiRNA-Disease Association prediction
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00499K, PaperLihong Peng, Ye-Qing Chen, Ning Ma, Xing Chen An increasing amount of evidence indicates that microRNAs (miRNAs) are closely related to many important biological processes and play a significant role in various human diseases. More and more researchers... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - October 11, 2017 Category: Molecular Biology Authors: Lihong Peng Source Type: research
MicroRNA-590-5p regulates cell viability, apoptosis, migration and invasion of renal cell carcinoma cell lines through targeting ARHGAP24
Mol. BioSyst., 2017, Advance Article DOI: 10.1039/C7MB00406K, PaperLei Wang, Wan-qing Wei, Zi-yu Wu, Gong-cheng Wang Renal cell carcinoma (RCC) is the leading cause of death in renal malignancies. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - October 11, 2017 Category: Molecular Biology Authors: Lei Wang Source Type: research
Pre-steady-state kinetic analysis of damage recognition by human single-strand selective monofunctional uracil-DNA glycosylase SMUG1
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00457E, PaperAlexandra Kuznetsova, Danila Iakovlev, Inna Misovets, Alexander Ishchenko, Murat Saparbaev, Nikita Kuznetsov, Olga S. Fedorova In all organisms, DNA glycosylases initiate base excision repair pathways resulting in removal of aberrant bases from DNA. Human SMUG1 belongs to the superfamily of uracil-DNA glycosylases catalyzing the hydrolysis... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - October 11, 2017 Category: Molecular Biology Authors: Alexandra Kuznetsova Source Type: research
Molecular dynamics simulations of [small beta]2-microglobulin interaction with hydrophobic surfaces
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00464H, PaperCedrix J. Dongmo Foumthuim, Alessandra Corazza, Gennaro Esposito, Federico Fogolari Hydrophobic surfaces are known to adsorb and to unfold proteins, a process that has been studied only for few proteins. Here we address the interaction of [small beta]2-microglobulin, a paradigmatic protein... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - October 9, 2017 Category: Molecular Biology Authors: Cedrix J. Dongmo Foumthuim Source Type: research
A Bayesian Approach for Estimating Protein-Protein Interactions by Integrating Structural and Non-Structural Biological Data
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00484B, PaperHafeez Ur Rehman, Inam Bari, Anwar Ali, Haroon Mahmood Abstract--- Accurate elucidation of genome wide protein-protein interactions is crucial for understanding regulatory processes of the cell. High-throughput techniques, such as yeast-2-hybrid (Y2H) assay, Co-Immunoprecipitation (co-IP), mass spectrometric (MS) protein... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - October 5, 2017 Category: Molecular Biology Authors: Hafeez Ur Rehman Source Type: research
Exploring the role of GS-GOGAT cycle in microcystin synthesis and regulation - a model based analysis
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00342K, PaperSwarnendu Banerjee, Abhishek Subramanian, Joydev Chattopadhyay, RamRup Sarkar Toxic cyanobacteria blooms populate water bodies by consuming external nutrients and releasing cyanotoxins that are detrimental for other aquatic species, producing a significant impact on the plankton ecosystem and food... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - October 5, 2017 Category: Molecular Biology Authors: Swarnendu Banerjee Source Type: research
Protein-protein[space]interaction[space]networks as a new perspective to evaluate distinct functional roles of voltage-dependent anion channel isoforms
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00434F, Review ArticleMarianna Caterino, Margherita Ruoppolo, Annalisa Mandola, Michele Costanzo, Stefania Orru, Esther Imperlini Voltage-dependent anion channels (VDACs) are a family of three mitochondrial porins and the most abundant integral membrane proteins of mitochondrial outer membrane (MOM). VDACs are known to be involved in... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - October 5, 2017 Category: Molecular Biology Authors: Marianna Caterino Source Type: research
Hybrid deterministic/stochastic simulation of complex biochemical systems
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00426E, PaperPaola Lecca, Fabio Bagagiolo, Marina Scarpa In a biological cell, cellular functions and the genetic regulatory apparatus are implemented and controlled by complex networks of chemical reactions involving genes, proteins, and enzymes. Accurate computational models are... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - September 29, 2017 Category: Molecular Biology Authors: Paola Lecca Source Type: research
Metabolomics reveal mitochondrial and fatty acid metabolism disorders that contribute to the development of DKD in T2DM patients
Mol. BioSyst., 2017, Advance Article DOI: 10.1039/C7MB00167C, PaperLing Li, Chengshi Wang, Hongliu Yang, Shuyun Liu, Yanrong Lu, Ping Fu, Jingping Liu Diabetic kidney disease (DKD) is the leading cause of ESRD; however, early intervention can greatly prevent the progression of DKD; thus, sensitive biomarkers for DKD are still required. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - September 28, 2017 Category: Molecular Biology Authors: Ling Li Source Type: research
Identification of a suitable promoter for the sigma factor of Mycobacterium tuberculosis
Mol. BioSyst., 2017, Advance Article DOI: 10.1039/C7MB00317J, PaperA. Mallick Gupta, S. Mukherjee, A. Dutta, J. Mukhopadhyay, D. Bhattacharyya, S. Mandal Promoter binding specificity is one of the important characteristics of transcription byMycobacterium tuberculosis (Mtb) sigma ([sigma]) factors, which remains unexplored due to limited structural evidence. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - September 27, 2017 Category: Molecular Biology Authors: A. Mallick Gupta Source Type: research
PANDAR: a pivotal cancer-related long non-coding RNA in human cancers
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00414A, Review ArticleJinglin Li, Zhenglong Li, Wangyang Zheng, Xinheng Li, Zhidong Wang, Yunfu Cui, Xingming Jiang Long non-coding RNAs (lncRNAs), a type of non-protein-coding RNAs that are more than 200 nucleotides in length, have been demonstrated to play a vital role in pathophysiology of human diseases,... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - September 26, 2017 Category: Molecular Biology Authors: Jinglin Li Source Type: research
The Henipavirus V protein is a prevalently unfolded protein with a zinc-finger domain involved in binding to DDB1
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00488E, PaperEdoardo Salladini, Vincent Delauzun, Sonia Longhi Henipaviruses are severe human pathogens within the Paramyxoviridae family. Beyond the P protein, the Henipavirus P gene also encodes the V protein which shares with P its N-terminal, intrinsically disordered... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - September 26, 2017 Category: Molecular Biology Authors: Edoardo Salladini Source Type: research
