Comparison of Leptospira interrogans and Leptospira biflexa genomes: analysis of potential leptospiral-host interactions
Mol. BioSyst., 2017, Advance Article DOI: 10.1039/C6MB00856A, PaperPrachi Mehrotra, Gayatri Ramakrishnan, Gunasekaran Dhandapani, Narayanaswamy Srinivasan, Madathiparambil G. Madanan Comparative analyses of leptospiral-host interactions between pathogenic and non-pathogenic leptospires aided in identifying potential mechanisms of species-specific persistence and immune clearance in human hosts. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - March 15, 2017 Category: Molecular Biology Authors: Prachi Mehrotra Source Type: research
Outstanding Reviewers for Molecular BioSystems in 2016
Mol. BioSyst., 2017, Advance Article DOI: 10.1039/C7MB90013A, Editorial We would like to take this opportunity to highlight the Outstanding Reviewers forMolecular BioSystems in 2016, as selected by the editorial team for their significant contribution to the journal. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - March 15, 2017 Category: Molecular Biology Source Type: research
The Ca2+-ATPase pump facilitates bidirectional proton transport across the sarco/endoplasmic reticulum
Mol. BioSyst., 2017, Advance Article DOI: 10.1039/C7MB00065K, OpinionL. Michel Espinoza-Fonseca We propose that the Ca2+-ATPase pump forms pores that facilitate bidirectional proton transport across the sarco/endoplasmic reticulum. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - March 14, 2017 Category: Molecular Biology Authors: L. Michel Espinoza-Fonseca Source Type: research
The nature of the conserved basic amino acid sequences found among 437 heparin binding proteins determined by network analysis
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C6MB00857G, PaperTimothy Robert Rudd, Mark D Preston, Edwin Yates In multicellular organisms, a large number of proteins interact with the polyanionic polysaccharides heparan sulphate (HS) and heparin. These interactions are usually assumed to be dominated by charge-charge interactions between... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - March 14, 2017 Category: Molecular Biology Authors: Timothy Robert Rudd Source Type: research
Molecular Dynamics Simulations Elucidate Conformational Selection and Induced Fit Mechanisms in the Binding of PD-1 and PD-L1
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00036G, PaperWenping Liu, Bing Huang, Yashu Kuang, Guangjian Liu Blockage of the interactions between immunologic checkpoint protein PD-1 and its ligand PD-L1 showed efficacy for cancer treatment. X-ray structures have captured static conformational snapshots of PD-1 and revealed that... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - March 14, 2017 Category: Molecular Biology Authors: Wenping Liu Source Type: research
Prediction of metabolic fluxes from gene expression data with Huber penalty convex optimization function
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C6MB00811A, PaperShaowu Zhang, wang-long gou, Yan Li Abstract ： As one of the critical parameter of a metabolic pathway, the metabolic flux in a metabolic network serves as an essential role in physiology and pathology. Constraint-based metabolic models... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - March 14, 2017 Category: Molecular Biology Authors: Shaowu Zhang Source Type: research
Optimal parameter values for the control of gene regulation
Mol. BioSyst., 2017, Advance Article DOI: 10.1039/C6MB00765A, PaperR. G. Brajesh, Nikhil Raj, Supreet Saini How does a transcription network arrive at the particular values of biochemical interactions defining it? To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - March 8, 2017 Category: Molecular Biology Authors: R. G. Brajesh Source Type: research
Metabolic profiling study of shikonin's cytotoxic activity in the Huh7 human hepatoma cell line
Mol. BioSyst., 2017, Advance Article DOI: 10.1039/C6MB00830E, PaperE. D. Spyrelli, A. V. Kyriazou, C. Virgiliou, A. Nakas, O. Deda, V. P. Papageorgiou, A. N. Assimopoulou, H. G. Gika Metabolic profiling employed for the first time on Huh7 cells upon treatment with shikonin could provide insight into the metabolic perturbations induced by shikonin. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - March 7, 2017 Category: Molecular Biology Authors: E. D. Spyrelli Source Type: research
The Ca2+-ATPase facilitates bidirectional proton transport across the sarco/endoplasmic reticulum
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00065K, OpinionL. Michel Espinoza-Fonseca Ca2+ transport across the sarco/endoplasmic plasmic reticulum (SR) plays an essential role in intracellular Ca2+ homeostasis, signalling, cell differentiation and muscle contractility. During SR Ca2+ uptake and release, proton fluxes... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - March 7, 2017 Category: Molecular Biology Authors: L. Michel Espinoza-Fonseca Source Type: research
Comparison of Leptospira interrogans and Leptospira biflexa genomes: Analysis on potential leptospiral-host interactions
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C6MB00856A, PaperPrachi Mehrotra, Gayatri Ramakrishnan, Gunasekaran Dhandapani, Narayanaswamy Srinivasan, Madathiparambil Gopalakrishnan Madanan A potentially life-threatening disease, Leptospirosis remains the most widespread zoonosis caused by pathogenic species of Leptospira. The pathogenic spirochaete, Leptospira interrogans, is characterized by its ability to permeate human host... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - March 3, 2017 Category: Molecular Biology Authors: Prachi Mehrotra Source Type: research
Optimal parameter values for control of gene regulation.
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C6MB00765A, PaperR G Brajesh, Nikhil Raj, Supreet Saini How does a transcription network arrive at particular values of biochemical interactions defining it? These interactions define DNA-transcription factor interaction; degradation rates of proteins; promoter strengths; and communication of the... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - February 28, 2017 Category: Molecular Biology Authors: R G Brajesh Source Type: research
How RNase HI (Escherichia coli) promoted site-selective hydrolysis works on RNA in duplex with carba-LNA and LNA substituted antisense strands in antisense strategy context
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C6MB00762G, PaperOleksandr Plashkevych, Qing Li, Jyoti Chattopadhyaya A detailed kinetic study of 36 single modified AON-RNA heteroduplexes show that a substitution of a single native nucleotide in the antisense strand (AON) by Locked Nucleic Acid (LNA) or... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - February 25, 2017 Category: Molecular Biology Authors: Oleksandr Plashkevych Source Type: research
Screening Methods for Identifying Pharmacological Chaperones
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C6MB00866F, Review ArticleMin Hyeon Shin, Hyun-Suk Lim Protein folding is crucial for most proteins to achieve their correct three-dimensional conformations and function properly. Defects in protein folding frequently caused by mutations lead to a range of protein... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - February 23, 2017 Category: Molecular Biology Authors: Min Hyeon Shin Source Type: research
Steady state statistical correlations predict bistability in reaction motifs
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00052A, PaperSuchana Chakravarty, Debashis Barik Various cellular decision making processes are regulated by bistable switches that take graded input signals and convert it to binary all-or-none responses. Traditionally a bistable switch generated by a positive... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - February 21, 2017 Category: Molecular Biology Authors: Suchana Chakravarty Source Type: research
Environmental factors and risk of aggressive prostate cancer among a population of New Zealand men - a genotypic approach
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C6MB00873A, PaperVenkatesh Vaidyanathan, Vijay Naidu, Chi Hsiu-Juei Kao, Nishi Karunasinghe, Karen S Bishop, Alice Wang, Radha Pallati, Phillip Shepherd, Jonathan Masters, Shuotun Zhu, Megan Goudie, Mohanraj Krishnan, Anower Jabed, Gareth Marlow, Ajit Narayanan, Lynette Ferguson Prostate cancer is one of the most significant male health concerns worldwide. Numerous researchers carrying out molecular diagnostics have indicated that genetic interactions with biological and behavioral factors play an... The content of this RSS Feed (c) The Royal Society of Chemistry (Sourc...
Source: RSC - Molecular Biosystems - February 21, 2017 Category: Molecular Biology Authors: Venkatesh Vaidyanathan Source Type: research
