pLoc-mPlant: predict subcellular localization of multi-location plant proteins by incorporating the optimal GO information into general PseAAC
Mol. BioSyst., 2017, Advance Article DOI: 10.1039/C7MB00267J, PaperXiang Cheng, Xuan Xiao, Kuo-Chen Chou One of the fundamental goals in cellular biochemistry is to identify the functions of proteins in the context of compartments that organize them in the cellular environment. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - July 12, 2017 Category: Molecular Biology Authors: Xiang Cheng Source Type: research
Functional roles of intrinsic disorder in CRISPR-associated protein Cas9
Mol. BioSyst., 2017, Advance Article DOI: 10.1039/C7MB00279C, PaperZhihua Du, Vladimir N. Uversky Protein intrinsic disorder is an important characteristic commonly detected in multifunctional or RNA- and DNA-binding proteins. We show here that the CRISPR-associated Cas9 proteins of different origin contain functionally important intrinsically disordered regions. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - July 11, 2017 Category: Molecular Biology Authors: Zhihua Du Source Type: research
Expediting dynamics approach to understand the influence of 14-3-3[small zeta] causing metastatic cancer through the interaction of YAP1 and [small beta]-TRCP
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00271H, PaperKamalesh D, Sriroopreddy Ramireddy, Raghuraman P, Sudandiradoss C 14-3-3[small zeta] acts as molecular switch in regulating TGF-[small beta] pathway, which turns from tumor suppressor in early stage of breast cancer to metastatic promoter in late stage. Such drift is due... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - July 11, 2017 Category: Molecular Biology Authors: Kamalesh D Source Type: research
Unveiling a VEGF-mimetic peptide sequence in the IQGAP1 protein
Mol. BioSyst., 2017, Advance Article DOI: 10.1039/C7MB00190H, PaperDomenica Capasso, Sonia Di Gaetano, Veronica Celentano, Donatella Diana, Luisa Festa, Rossella Di Stasi, Lucia De Rosa, Roberto Fattorusso, Luca D. D'Andrea A peptide able to recapitulate the VEGF effect on ECs was derived from the IQGAP1 protein sequence. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - July 7, 2017 Category: Molecular Biology Authors: Domenica Capasso Source Type: research
Identification of microRNA precursors using reduced and hybrid features
Mol. BioSyst., 2017, Advance Article DOI: 10.1039/C7MB00115K, PaperAsad Khan, Sajid Shah, Fazli Wahid, Fiaz Gul Khan, Saima Jabeen We have developed a predictor called MicroR-Pred in which the RNA sequences are formulated by a hybrid feature vector. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - July 7, 2017 Category: Molecular Biology Authors: Asad Khan Source Type: research
An efficient method to transcription factor binding sites imputation via simultaneous completion of multiple matrices with positional consistency
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00155J, PaperWei-Li Guo, De-Shuang Huang Transcription factors (TFs) are DNA-binding proteins that have a central role in regulating gene expression. Identification of DNA-binding sites of TFs is a key task in understanding transcriptional regulation, cellular... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - July 6, 2017 Category: Molecular Biology Authors: Wei-Li Guo Source Type: research
Association of cultured myotubes and fasting plasma metabolite profiles with mitochondrial dysfunction in Type 2 diabetes subjects
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00333A, PaperMohamad Hafizi Abu Bakar, Mohamad Roji Sarmidi Accumulating evidence implicates mitochondrial dysfunction-induced insulin resistance in skeletal muscle as the root cause for greatest hallmarks of type 2 diabetes (T2D). However, the identification of specific metabolite-based markers linking... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - July 5, 2017 Category: Molecular Biology Authors: Mohamad Hafizi Abu Bakar Source Type: research
Insights into the RNA binding mechanism of human L1-ORF1p: a molecular dynamics study
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00358G, PaperMuthukumaran Rajagopalan, Sangeetha Balasubramanian, Amutha Ramaswamy The recognition and binding of nucleic acids by ORF1p, an L1 retrotransposon protein, has not yet been clearly understood due to the lack of structural knowledge. The present study attempts... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - July 5, 2017 Category: Molecular Biology Authors: Muthukumaran Rajagopalan Source Type: research
DBA-induced caspase-3-dependent apoptosis occurs through mitochondrial translocation of cyt-c in rat hippocampus
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00246G, Paperwenbo Jiang, Yingying Chen, Bai Li, shuying Gao Dibromoacetic acid (DBA), a by-product of disinfection, develops in drinking water during the chlorination or ozonation process. Water intake is the main source of DBA exposure in humans, which is... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - July 5, 2017 Category: Molecular Biology Authors: wenbo Jiang Source Type: research
Metabolomics combined with pattern recognition and bioinformatics analysis methods for the development of pharmacodynamic biomarkers on liver fibrosis
Mol. BioSyst., 2017, Advance Article DOI: 10.1039/C7MB00093F, PaperJunwei Fang, Liping Wang, Yang Wang, Mingfeng Qiu, Yongyu Zhang Metabolomics combined with pattern recognition and network analysis maybe an attractive strategy for the pharmacodynamics biomarkers development on liver fibrosis. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - July 3, 2017 Category: Molecular Biology Authors: Junwei Fang Source Type: research
Tetracycline-controllable artificial microRNA-HOTAIR + EZH2 suppressed the progression of bladder cancer cells
Mol. BioSyst., 2017, Advance Article DOI: 10.1039/C7MB00202E, PaperYincong Chen, Haibiao Xie, Yifan Zou, Xiulan Lai, Lian Ma, Yuchen Liu, Jianfa Li Previous studies have suggested that EZH2 is up-regulated in bladder cancer tissues and identified it as a biomarker for poor prognosis. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - July 3, 2017 Category: Molecular Biology Authors: Yincong Chen Source Type: research
Understanding the Role of Tyrosine in Glycogenin
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00293A, CommunicationAnder Camiruaga, Imanol Usabiaga, Aran Insausti, Emilio Jose Cocinero, Iker Leon, Jose A. Fernandez We explored the molecular basis of tyrosine as the docking amino acid for the first glucose molecule during the systhesis of glucogen. The IR spectra show that the aromatic ring... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - June 30, 2017 Category: Molecular Biology Authors: Ander Camiruaga Source Type: research
An enhanced hTERT promoter-driven CRISPR/Cas9 system selectively inhibits the progression of bladder cancer cells
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00354D, PaperXinbo Huang, Chengle Zhuang, Changshui Zhuang, Tiefu Xiong, Yawen Li, Yaoting Gui The current therapies in treating tumors are lack of efficacy and specificity. Synthetic biology principles may bring some new possible methods to cure cancer. Here we present a synthetic logic... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - June 30, 2017 Category: Molecular Biology Authors: Xinbo Huang Source Type: research
C-Peptide Replacement Therapy in Type 1 Diabetes: Are We in the Trough of Disillusionment?
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00199A, Review ArticleCody W Pinger, Tiffany M Bell, Kristen Entwistle, Yueli Liu, Dana Spence Type 1 Diabetes is associated with such complications as blindness, kidney failure, and nerve damage. Replacing C-peptide, a hormone normally co-secreted with insulin, has been shown to reduce diabetes-related complications.... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - June 30, 2017 Category: Molecular Biology Authors: Cody W Pinger Source Type: research
The Antiproliferative Activity of Di-2-pyridylketone Dithiocarbamate Partly Attributed to Catalase Inhibition: Detailed the Interaction by Spectroscopic Methods
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00032D, Papercuiping Li, youxun liu, yun Fu, tengfei huang, lixia kang, changzheng li Bioactivity of drugs attributes to their interaction with biological molecules, embodied in either direct or indirect influence of enzyme activity and conformation. Di-2-pyridylketone hydrazine dithiocarbamate (DpdtC) exhibits significant antitumor activity... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - June 30, 2017 Category: Molecular Biology Authors: cuiping Li Source Type: research
