Crystal structure of Aquifex aeolicus gene product Aq1627: A putative phosphoglucosamine mutase reveals a unique C-terminal end-to-end disulfide linkage
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00182G, PaperUpasana Sridharan, Kuramitsu Seiki, Yokoyama Shigeyuki, Kumarevel Thirumananseri, Karthe Ponnuraj The Aq1627 gene from Aquifex aeolicus, a hyperthermophilic bacterium has been cloned and overexpressed in Escherichia coli. The protein was purified to homogeneity and its X-ray crystal structure was determined... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - May 17, 2017 Category: Molecular Biology Authors: Upasana Sridharan Source Type: research
Metabolomics Combined with Pattern Recognition and Bioinformatics Analysis Methods for the Pharmacodynamic Biomarkers Development on Liver Fibrosis
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00093F, PaperJunwei Fang, Liping Wang, Yang Wang, M. Qiu, Yongyu Zhang The major obstacle for the development of targeted therapies is lacking of pharmacodynamics (PD) biomarkers to provide an early read out of biological activity. As the modulation of metabolites may... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - May 17, 2017 Category: Molecular Biology Authors: Junwei Fang Source Type: research
Tumor suppressors microRNA-302d and microRNA-16 inhibit human glioblastoma multiforme by targeting NF-[small kappa]B and FGF2
Mol. BioSyst., 2017, Advance Article DOI: 10.1039/C7MB00139H, PaperFeng Wang, Lijun Yang, Jianping Sun, Jun Zheng, Lin Shi, Gengshen Zhang, Na Cui MicroRNA-302d and microRNA-16 inhibit glioblastoma multiforme by targeting NF-[small kappa]B p65 and FGF2. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - May 17, 2017 Category: Molecular Biology Authors: Feng Wang Source Type: research
Structure based in silico identification of potentially non-steroidal brassinosteroids mimics
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00214A, PaperBeilei Lei, Ningjuan Heng, Xiaoxue Dang, Jiyuan Liu, xiaojun yao, Cunli Zhang The plant steroid hormone, brassinosteroids (BRs), plays indispensable roles in cell elongation, division and plant development. To date, massive synthesis of BRs analogs and structure-activity relationship investigations have exhibit us... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - May 17, 2017 Category: Molecular Biology Authors: Beilei Lei Source Type: research
FOCuS: A metaheuristic algorithm for computing knockouts from genome-scale models for strain optimization
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00204A, PaperSarma V.R.K Mutturi Although handful tools for constraint-based flux analysis to generate knockout strains are available, most of these are either based on bilevel- MIP or its modifications. Metaheuristic approaches which are known... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - May 9, 2017 Category: Molecular Biology Authors: Sarma V.R.K Mutturi Source Type: research
Differential flap dynamics in L,D-transpeptidase2 from mycobacterium tuberculosis revealed by molecular dynamics
Mol. BioSyst., 2017, Advance Article DOI: 10.1039/C7MB00110J, PaperZeynab Fakhar, Thavendran Govender, Glenn E. M. Maguire, Gyanu Lamichhane, Ross C. Walker, Hendrik G. Kruger, Bahareh Honarparvar The implications of inhibitor binding on the flap dynamics inL,D-transpeptidase2 from mycobacterium tuberculosis. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - May 9, 2017 Category: Molecular Biology Authors: Zeynab Fakhar Source Type: research
Systematic comparison of the response properties of protein and RNA mediated gene regulatory motifs
Mol. BioSyst., 2017, Advance Article DOI: 10.1039/C6MB00808A, PaperBharat Ravi Iyengar, Beena Pillai, K. V. Venkatesh, Chetan J. Gadgil Dissection of the effect of motif structure, controller, and regulation mode identifies properties common across motifs, and others dependent more on controller nature. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - May 9, 2017 Category: Molecular Biology Authors: Bharat Ravi Iyengar Source Type: research
Metabolomic profiling and biochemical evaluation of the follicular fluid of endometriosis patients
Mol. BioSyst., 2017, Advance Article DOI: 10.1039/C7MB00181A, PaperSantonastaso Marianna, Pucciarelli Alessia, Costantini Susan, Caprio Francesca, Sorice Angela, Capone Francesca, Natella Antonella, Iardino Patrizia, Colacurci Nicola, Chiosi Emilio Integration of the metabolic profile, the inflammatory state and the cell damage in the follicular fluid of women with endometriosis. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - May 5, 2017 Category: Molecular Biology Authors: Santonastaso Marianna Source Type: research
Characterizing the structure-function relationship reveals the mode of action of a novel antimicrobial peptide, P1, from jumper ant Myrmecia pilosula
Mol. BioSyst., 2017, Advance Article DOI: 10.1039/C6MB00810K, PaperTien-Sheng Tseng, Keng-Chang Tsai, Chinpan Chen Microbial infections of antibiotic-resistant strains cause serious diseases and have a significant impact on public health worldwide, so novel antimicrobial drugs are urgently needed. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - May 5, 2017 Category: Molecular Biology Authors: Tien-Sheng Tseng Source Type: research
Reconstruction and analysis of the lncRNA-miRNA-mRNA network based on competitive endogenous RNA reveal functional lncRNAs in rheumatoid arthritis
Mol. BioSyst., 2017, Advance Article DOI: 10.1039/C7MB00094D, PaperHui Jiang, Rong Ma, Shubiao Zou, Yongzhong Wang, Zhuqing Li, Weiping Li Rheumatoid arthritis (RA) is an autoimmune disease with an unknown etiology, occurring in approximately 1.0% of general population. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - May 5, 2017 Category: Molecular Biology Authors: Hui Jiang Source Type: research
The impact of Thr91 mutation on c-Src resistance to UM-164: molecular dynamics study revealed a new opportunity for drug design
Mol. BioSyst., 2017, Advance Article DOI: 10.1039/C6MB00848H, PaperUmar Ndagi, Ndumiso N. Mhlongo, Mahmoud E. Soliman The emergence of a drug resistant non-receptor tyrosine kinase (c-Src) in triple-negative breast cancer (TNBC) remains a prime concern in relation to the burden of TNBC among people living with breast cancer and drug development. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - May 2, 2017 Category: Molecular Biology Authors: Umar Ndagi Source Type: research
Metabolomic profiling and biochemical evaluation in follicular fluid of endometriosis patients
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00181A, PaperMarianna Santonastaso, Alessia Pucciarelli, Susan Costantini, Francesca Caprio, Angela Sorice, Francesca Capone, Antonella Natellla, Patrizia Iardino, Nicola Colacurci, Emilio Chiosi The diseases are complex systems that can be studied through the integration of data deriving from different disciplines to obtain a global and reliable picture of biological phenomenon under investigation.... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - April 27, 2017 Category: Molecular Biology Authors: Marianna Santonastaso Source Type: research
Emergent properties of extracellular vesicles: a holistic approach to decode the complexity of intercellular communication networks
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00146K, Review ArticleYong Song Gho, Changjin Lee Shedding of nano-sized bilayered extracellular vesicles and extracellular vesicle-mediated intercellular communication are evolutionarily conserved biological processes. Communication between cells and the environment is an essential process in living organisms and... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - April 27, 2017 Category: Molecular Biology Authors: Yong Song Gho Source Type: research
Characterizing structure-function relationship reveals mode of action of a novel antimicrobial peptide, P1, from jumper ant Myrmecia pilosula
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C6MB00810K, PaperTien-Sheng Tseng, Keng-Chang Tsai, Chinpan Chen Microbial infections of antibiotic-resistant strains cause serious diseases and have a significant impact on public-health worldwide, so novel antimicrobial drugs are urgently needed. Insect venoms, a rich source of bioactive... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - April 25, 2017 Category: Molecular Biology Authors: Tien-Sheng Tseng Source Type: research
Characterization of the structure, dynamics and allosteric pathways of human NPP1 in its free form and substrate-bound complex from molecular modeling
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00095B, PaperXavier Barbeau, Patrick Mathieu, Jean-Francois Paquin, Patrick Lague The ectonucleotide phosphodiesterase/pyrophosphatase-1 (NPP1) is a type II transmembrane glycoprotein that regulates extracellular purine nucleotide and inorganic diphosphate levels through the hydrolysis of ATP into AMP and diphosphate. NPP1 is... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - April 25, 2017 Category: Molecular Biology Authors: Xavier Barbeau Source Type: research
