Not an Exception to the Rule: The Functional Significance of Intrinsically Disordered Protein Regions in Enzymes
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C6MB00741D, CommunicationShelly DeForte, Vladimir N. Uversky Intrinsically disordered protein regions (IDPRs) are remarkably common and have unique and important biological functions. Enzymes have long been considered an exception to the rule of protein intrinsic disorder due... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - January 12, 2017 Category: Molecular Biology Authors: Shelly DeForte Source Type: research
Changes in protein expression profiles in bovine endometrial epithelial cells exposed to E. coli LPS challenge
Mol. BioSyst., 2017, Advance Article DOI: 10.1039/C6MB00723F, PaperCristian Piras, Yongzhi Guo, Alessio Soggiu, Metasu Chanrot, Viviana Greco, Andrea Urbani, Gilles Charpigny, Luigi Bonizzi, Paola Roncada, Patrice Humblot Proteomics of the physiological response of bEECs to LPS challenge to unravel the possible implication of bacterial infection in pregnancy establishment. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - January 10, 2017 Category: Molecular Biology Authors: Cristian Piras Source Type: research
Network pharmacology-based virtual screening of natural products from Clerodendrum species for identification of novel anti-cancer therapeutics
Mol. BioSyst., 2017, Advance Article DOI: 10.1039/C6MB00807K, PaperBarbi Gogoi, Dhrubajyoti Gogoi, Yumnam Silla, Bibhuti Bhushan Kakoti, Brijmohan Singh Bhau In the present work, latest network pharmacological approach has been used for the screening of natural anticancer compounds fromClerodendrum species. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - January 10, 2017 Category: Molecular Biology Authors: Barbi Gogoi Source Type: research
Inference of Cancer Mechanisms through Computational Systems Analysis
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C6MB00672H, PaperZhen Qi, Eberhard O. Voit Large amounts of metabolomics data have been accumulated to study metabolic alterations in cancer that allow cancer cells to synthesize molecular materials necessary for cell growth and proliferation. Although metabolic... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - January 10, 2017 Category: Molecular Biology Authors: Zhen Qi Source Type: research
A systems approach for elucidation of crucial genes and network constituents of cervical intraepithelial neoplasia 1(CIN1)
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C6MB00615A, PaperShikha Suman, Ashutosh Mishra, Anurag Kulshrestha Cervical intra-epithelial neoplasia 1 (CIN1) is a pre-cancerous cervical cancer condition characterized by changes in the squamous cells of the cervix. Early detection may facilitate treatment as CIN1 may increase... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - January 10, 2017 Category: Molecular Biology Authors: Shikha Suman Source Type: research
The DNA target determines the dimerization partner selected by bHLHZ-like hybrid proteins AhRJun and ArntFos
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C6MB00795C, PaperIchiro Inamoto, Gang Chen, Jumi Shin The molecular basis of protein-partner selection and DNA binding of the basic helix-loop-helix (bHLH) and basic region-leucine zipper (bZIP) superfamilies of dimeric transcription factors is fundamental toward understanding gene regulation.... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - January 10, 2017 Category: Molecular Biology Authors: Ichiro Inamoto Source Type: research
The functional consequences and prognostic value of dosage sensitivity in ovarian cancer
Mol. BioSyst., 2017, Advance Article DOI: 10.1039/C6MB00625F, PaperZichuang Yan, Yongjing Liu, Yunzhen Wei, Ning Zhao, Qiang Zhang, Cheng Wu, Zhiqiang Chang, Yan Xu Copy number alteration (CNA) represents an important class of genetic variations that may contribute to tumorigenesis, tumor growth and metastatic spread. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - January 9, 2017 Category: Molecular Biology Authors: Zichuang Yan Source Type: research
Topologically inferring pathway activity for precise survival outcome prediction: breast cancer as a case
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C6MB00757K, PaperWei Liu, Wei Wang, Guohua Tian, Wenming Xie, Li Lei, Jiujin Liu, Wanxun Huang, Liyan Xu, Enmin Li Accurately predicting the survival outcome of patients is of great importance in clinical cancer research. In the past decade, building survival prediction models based on gene expression data has received... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - January 9, 2017 Category: Molecular Biology Authors: Wei Liu Source Type: research
Soluble epoxide hydrolase inhibitor might prevent ischemic arrhythmias via microRNA-1 repression in primary neonatal mouse ventricular myocytes
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C6MB00824K, PaperQiong Liu, Xuan Zhao, Ran Peng, Mi Wang, Wang Zhao, Yajun Gui, Caixiu Liao, Danyan Xu Abstract Background: Ischemic arrhythmias are the main causes of sudden cardiac death. It has been reported that soluble epoxide hydrolase inhibitors (sEHis) could prevent arrhythmias; however, the underlying molecular mechanisms... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - January 7, 2017 Category: Molecular Biology Authors: Qiong Liu Source Type: research
Metabolic profiling of a myalgic encephalomyelitis/chronic fatigue syndrome discovery cohort reveals disturbances in fatty acid and lipid metabolism
Mol. BioSyst., 2017, Advance Article DOI: 10.1039/C6MB00600K, PaperArnaud Germain, David Ruppert, Susan M. Levine, Maureen R. Hanson This work exposes disturbances in major metabolic pathways while providing a prospective path both for diagnosis and underlying ME/CFS/SEID mechanisms. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - January 6, 2017 Category: Molecular Biology Authors: Arnaud Germain Source Type: research
An andrographolide derivative AGP-26b exhibiting anti-angiogenic activity in HUVECs and zebrafish via blocking VEGFA/VEGFR2 signaling pathway
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C6MB00641H, PaperBin Huang, Yuran Peng, Jingjing Li, Shang Li, Yicheng Sun, Decai Wang, Judy Yuet-Wa Chan, Hui Dong Yu, G.P. Leung, Maggie Pui Man Hoi, Guo-Chun Zhou, Simon Ming-Yuen Lee The aims of this study is to investigate the anti-angiogenic properties of Andrographolide derivatives AGP-26a (12[small beta]-isomer), AGP-26b (12[small alpha]-isomer) and AGP-26 (4:1 mixture of AGP-26a and AGP-26b) in vitro and in... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - January 5, 2017 Category: Molecular Biology Authors: Bin Huang Source Type: research
In Silico Identification of Human Bile Salt Export Pump (ABCB11) Inhibitors Associated with Cholestatic Drug-Induced Liver Injury
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C6MB00744A, PaperLili Xi, Jia Yao, Yuhui Wei, Xinan Wu, Xiaojun Yao, Huanxiang Liu, Shuyan Li Drug-induced liver injury (DILI) is one of the major causes of drug attrition and failure. Currently, there is increasing evidence that direct inhibition of human bile salt export pump (BSEP/ABCB11)... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - January 5, 2017 Category: Molecular Biology Authors: Lili Xi Source Type: research
Metabolomics and proteomics technologies to explore the herbal preparation affecting metabolic disorders using high resolution mass spectrometry
Mol. BioSyst., 2017, Advance Article DOI: 10.1039/C6MB00677A, CommunicationAihua Zhang, Xiaohang Zhou, Hongwei Zhao, Shiyu Zou, Chung Wah Ma, Qi Liu, Hui Sun, Liang Liu, Xijun Wang An integrative metabolomics and proteomics approach can provide novel insights in the understanding of biological systems. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - January 3, 2017 Category: Molecular Biology Authors: Aihua Zhang Source Type: research
Biochemical effects of venlafaxine on astrocytes as revealed by 1H NMR-based metabolic profiling
Mol. BioSyst., 2017, Advance Article DOI: 10.1039/C6MB00651E, PaperLu Sun, Liang Fang, Bin Lian, Jin-Jun Xia, Chan-juan Zhou, Ling Wang, Qiang Mao, Xin-Fa Wang, Xue Gong, Zi-Hong Liang, Shun-Jie Bai, Li Liao, Yu Wu, Peng Xie As a serotonin-norepinephrine reuptake inhibitor [SNRI], venlafaxine is one of the most commonly prescribed clinical antidepressants, with a broad range of antidepressant effects. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - January 3, 2017 Category: Molecular Biology Authors: Lu Sun Source Type: research
Metabolic profiling of a myalgic encephalomyelitis/chronic fatigue syndrome discovery cohort reveals disturbances in fatty acid and lipid metabolism
Mol. BioSyst., 2016, Accepted Manuscript DOI: 10.1039/C6MB00600K, PaperArnaud Germain, David Ruppert, Susan M Levine, Maureen R Hanson Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) remains a continuum spectrum disease without biomarkers or simple objective tests, and therefore relies on a diagnosis from a set of symptoms to link the... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - December 23, 2016 Category: Molecular Biology Authors: Arnaud Germain Source Type: research
