A Novel computational model based on super-disease and miRNA for potential miRNA-disease association prediction
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C6MB00853D, PaperXing Chen, Zhi-Chao Jiang, Di Xie, De-Shuang Huang, Qi Zhao, Gui-Ying Yan, Zhu-Hong You In recent years, more and more studies have indicated that microRNAs (miRNAs) play critical roles in various complex human diseases and could be regarded as important biomarkers for cancer detection... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - April 25, 2017 Category: Molecular Biology Authors: Xing Chen Source Type: research
Reconstruction and analysis of lncRNA-miRNA-mRNA network based on competitive endogenous RNA reveal functional lncRNAs in rheumatoid arthritis
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00094D, PaperHui Jiang, Rong Ma, Shubiao Zou, Zhuqing Li , Weiping Li Rheumatoid arthritis (RA) is an autoimmune disease with an unknown etiology, occurring in approximately 1.0% of general population. More and more studies have suggested that long non-coding RNAs (lncRNAs) could... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - April 25, 2017 Category: Molecular Biology Authors: Hui Jiang Source Type: research
GeneSPIDER - Gene regulatory network inference benchmarking with controlled network and data properties
We present GeneSPIDER--a Matlab... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - April 25, 2017 Category: Molecular Biology Authors: Andreas Tjarnberg Source Type: research
Microarray profiling and co-expression network analysis of the lncRNAs and mRNAs associated with acute leukemia in adults
This study is the first to explore genome-wide lncRNA expression and co-expression with mRNA patterns in AML and ALL using microarray technology. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - April 21, 2017 Category: Molecular Biology Authors: Hui Cheng Source Type: research
Generation and characterization of the blood transcriptome of Macaca thibetana and comparative analysis with M. mulatta
Mol. BioSyst., 2017, Advance Article DOI: 10.1039/C6MB00771F, PaperPeng Li, Lianming Du, Wujiao Li, Zhenxin Fan, Daiwen Zeng, Hui Chen, Liang Zhou, Yong Yi, Na Yang, Kefeng Dou, Bisong Yue, Jing Li Transcriptome profiles provide a large transcript sequence data set for genomic study, particularly in organisms that have no accurate genome data published. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - April 21, 2017 Category: Molecular Biology Authors: Peng Li Source Type: research
The multi-output incoherent feedforward loop constituted by the transcriptional regulators LasR and RsaL confers robustness to a subset of quorum sensing genes in Pseudomonas aeruginosa
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00040E, PaperRoslen Bondi, Francesca Longo, Marco Messina, Francesca D'Angelo, Paolo Visca, Livia Leoni, Giordano Rampioni Quorum sensing (QS) is an intercellular communication system which controls virulence-related phenotypes in the human pathogenPseudomonas aeruginosa. LasR is the QS receptor protein which responds to the signal molecule... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - April 21, 2017 Category: Molecular Biology Authors: Roslen Bondi Source Type: research
Effect of nucleobase change on cytosine deamination through DNA photo-cross-linking reaction via 3-cyanovinylcarbazole nucleoside
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00082K, PaperSiddhant Sethi, Minako Ooe, Takashi Sakamoto, Kenzo Fujimoto Photo-chemical deamination of cytosine using 3-cyanovinylcarbazole nucleoside (CNVK) mediated photo-crosslinking is a technique for site-directed mutagenesis. Using the technique in vivo requires the elimination of high-temperature incubation step and rather... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - April 21, 2017 Category: Molecular Biology Authors: Siddhant Sethi Source Type: research
An integrated anti-arrhythmic target network of a Chinese medicine compound, Wenxin Keli, revealed by combined machine learning and molecular pathway analysis
Mol. BioSyst., 2017, Advance Article DOI: 10.1039/C7MB00003K, PaperTaiyi Wang, Ming Lu, Qunqun Du, Xi Yao, Peng Zhang, Xiaonan Chen, Weiwei Xie, Zheng Li, Yuling Ma, Yan Zhu Deciphering the compound Wenxin Keli's anti-arrhythmic pharmacological mechanism by integrating network pharmacology and experimental verification methods. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - April 18, 2017 Category: Molecular Biology Authors: Taiyi Wang Source Type: research
An all-atom molecular dynamics study of the anti-interferon signaling of Ebola virus: interaction mechanisms of EBOV VP24 binding to Karyopherin alpha5
Mol. BioSyst., 2017, Advance Article DOI: 10.1039/C7MB00136C, PaperJing-Na Ding, Yan-Jun Zhang, Hui Zhong, Cheng-Cheng Ao, Jing Li, Ju-Guang Han Mutations of Q184/N185/H186, R137/T138/Q139, R398 and R396 residues lead to significant loss of binding affinity of VP24-KPNA5. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - April 18, 2017 Category: Molecular Biology Authors: Jing-Na Ding Source Type: research
Metabolic Profiling of asthma in mice and the interventional effects of SPA using Liquid Chromatography and Q-TOF Mass Spectrometry
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00025A, PaperLi Su, Lei Shi, Jian Liu, Lifei Huang, Yi Huang, Xiaomeng Nie Asthma is a chronic inflammatory lung disease lead to 250,000 deaths annually. It is need to better understand asthma by identifying new pathogenic molecules. We conducted a liquid-chromatography with time-of-flight... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - April 13, 2017 Category: Molecular Biology Authors: Li Su Source Type: research
Integrating multiple omics data for the discovery of potential Beclin-1 interactions in breast cancer
Mol. BioSyst., 2017, Advance Article DOI: 10.1039/C6MB00653A, PaperYi Chen, Xuan Wang, Guan Wang, Zhaozhi Li, Jinjin Wang, Lingyu Huang, Ziyi Qin, Xiang Yuan, Zhong Cheng, Shu Zhang, Yiqiong Yin, Jun He The genes and their three omics are computed to related to breast cancer using LASSO, a method for integrating multiple data. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - April 12, 2017 Category: Molecular Biology Authors: Yi Chen Source Type: research
Anticancer effects of novel resveratrol analogues on human ovarian cancer cells
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00128B, Paperdaniele vergara, Stefania De Domenico, Andrea Tinelli, Eleonora Stanca, Loretta L. del Mercato, ANNA MARIA GIUDETTI, Pasquale Simeone, Guazzelli Nicola, Marco Lessi, Chiara Manzini, Angelo Santino, Fabio Bellina, Michele Maffia Resveratrol, a naturally occurring phytoalexin, has long been known to have an important regulatory role of key functions in cell physiology. This multifunctional role of resveratrol is explained by its... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - April 11, 2017 Category: Molecular Biology Authors: daniele vergara Source Type: research
A Structural Bioinformatics investigation on protein-DNA complexes delineates their modes of interaction
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00071E, PaperSimone Gardini, Simone Furini, Annalisa Santucci, Neri Niccolai Lifetimes of protein-DNA adducts are strictly related to the various protein functions. This feature must be encoded by the amino acids located at protein-DNA interface. The large number of structurally... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - April 11, 2017 Category: Molecular Biology Authors: Simone Gardini Source Type: research
A metabolomic study on high-risk stroke patients determines low levels of serum lysine metabolites: a retrospective cohort study
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C6MB00732E, PaperYeseung Lee , Adnan Khan, Seri Hong, Sun Ha Jee, Y. Park Identification of changes in serum metabolites during cerebral ischemia is an important approach for early diagnosis of thrombotic stroke. Herein, we highlight novel biomarkers for early diagnosis of patients at... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - April 11, 2017 Category: Molecular Biology Authors: Yeseung Lee Source Type: research
Aggregation behavior of novel heptamethine cyanine dyes upon their binding to native and fibrillar lysozyme
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00185A, PaperKateryna Vus, Ulyana Tarabara, Atanas Kurutos, Olga Ryzhova, Galyna Gorbenko, Valeriya Trusova, Nikolai Gadjev, Todor Deligeorgiev Two newly synthesized symmetrical heptamethine cyanine dyes, AK7-5 and AK7-6, absorbing in the region of low autofluorescence of biological samples, have been tested for their ability to detect proteins aggregated... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - April 4, 2017 Category: Molecular Biology Authors: Kateryna Vus Source Type: research
