The characteristic landscape of lncRNAs classified by RBP-lncRNA interactions across 10 cancers
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00144D, PaperQiang Zhang, Yunzhen Wei, Zichuang Yan, Cheng Wu, Zhiqiang Chang, Yinling Zhu, Kun Li, Yan Xu RNA-binding proteins (RBPs) are key regulators of gene expression. Some long non-coding RNAs (lncRNAs) affect gene expression by interacting with RBPs. However, whether it influences the biological characteristic of lncRNAs... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - March 31, 2017 Category: Molecular Biology Authors: Qiang Zhang Source Type: research
Microarray profiling and co-expression network analysis of lncRNAs and mRNAs associated with acute leukemia in adult
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C6MB00874G, PaperHui Cheng, Chongmei Huang, Yang Wang, Xiaoxia Hu, Xiaoqian Xu, Xianmin Song, Gusheng Tang, Li Chen, Jianmin Yang Acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) of adult are common acute leukemia and have poor outcome with 5-years low survival despite high rates of complete remission (CR)... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - March 31, 2017 Category: Molecular Biology Authors: Hui Cheng Source Type: research
New insights into polyene macrolide biosynthesis in Couchioplanes caeruleus
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00112F, PaperJames Sheehan, Cormac D Murphy, Patrick Caffrey Couchioplanes caeruleus DSM43634 synthesises 67-121C, an aromatic heptaene macrolide that contains a mannosyl-mycosaminyl disaccharide. An improved draft genome sequence was used to obtain the biosynthetic gene cluster for this antifungal.... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - March 31, 2017 Category: Molecular Biology Authors: James Sheehan Source Type: research
Inhibition of the MurA enzyme in Fusobacterium nucleatum by potential inhibitors identified through computational and in vitro approaches
Mol. BioSyst., 2017, Advance Article DOI: 10.1039/C7MB00074J, PaperAmit Kumar, Rajagopalan Saranathan, K. Prashanth, Basant K. Tiwary, Ramadas Krishna Inhibition of MurA in open conformation by orientin and in closed conformation by quercetin-3-O-D-glucuronide with efficient inhibitory constant values. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - March 30, 2017 Category: Molecular Biology Authors: Amit Kumar Source Type: research
Structural modeling of the AhR:ARNT complex in the bHLH-PASA-PASB region elucidates the key determinants of dimerization
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00005G, PaperDario Corrada, Michael Denison, Laura Bonati Elucidation of the dimerization process of the Aryl hydrocarbon Receptor (AhR) with the AhR Nuclear Translocator (ARNT) is crucial for understanding the mechanisms underlying the AhR functional activity, including mediation... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - March 30, 2017 Category: Molecular Biology Authors: Dario Corrada Source Type: research
Systematic comparison of the response properties of protein and RNA mediated gene regulatory motifs.
We present a framework enabling dissection of the effects of motif structure (feedback or feedforward), nature of the controller (RNA or protein), and regulation mode (transcriptional, posttranscriptional, or translational) on... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - March 30, 2017 Category: Molecular Biology Authors: Bharat Ravi Iyengar Source Type: research
Small Molecule Induced Poly(A) Single Strand to Self-Structure Conformational Switching: Evidence for the Prominent Role of H-bonding Interactions
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00031F, PaperSabyasachi Chatterjee, Gopinatha Suresh Kumar All messenger RNAs (mRNA) have a polyadenylic acid tail that is added during the post transcriptional RNA processing. Investigations on the structure-function and interaction of polyadenylic acid is an important... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - March 29, 2017 Category: Molecular Biology Authors: Sabyasachi Chatterjee Source Type: research
Antibodies to H2a and H2b histones from the sera of HIV-infected patients catalyze site-specific degradation of these histones
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00042A, PaperSvetlana V. Baranova, Pavel S. Dmitrenok, Nikita V. Ivanisenko, Valentina N. Buneva, Georgy Alexandrovich Nevinsky Histones and their post-translational modifications have key roles in chromatin remodeling and gene transcription. Besides intranuclear functions, histones act as damage-associated molecules when they are released into the extracellular space.... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - March 28, 2017 Category: Molecular Biology Authors: Svetlana V. Baranova Source Type: research
Quantitative Proteomic Characterization of Redox-dependent Post-translational Modifications on Protein Cysteines
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C6MB00861E, Review ArticleJicheng Duan, Matthew J. Gaffrey, Wei-jun Qian Protein thiols play a crucial role in redox signaling, in the regulation of enzymatic activity and protein function, and in maintaining redox homeostasis in living systems. The unique chemical reactivity... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - March 27, 2017 Category: Molecular Biology Authors: Jicheng Duan Source Type: research
Cancerous perturbations within the ERK, PI3K/Akt, and Wnt/[small beta]-catenin signaling network constitutively activate inter-pathway positive feedback loops
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C6MB00786D, PaperRahul Rao Padala, Rishabh Karnawat, Satish Bharathwaj Viswanathan, Abhishek Vijay Thakkar, ASIM BIKAS DAS Perturbations in molecular signaling pathways are a result of genetic or epigenetic alterations, which may lead to malignant transformation of cells. Despite the cellular robustness, specific genetic or epigenetic changes... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - March 25, 2017 Category: Molecular Biology Authors: Rahul Rao Padala Source Type: research
An integrated anti-arrhythmic target network of compound Chinese medicine Wenxin Keli revealed by a combined machine learning and molecular pathway analysis
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00003K, PaperTaiyi Wang, Ming Lu, Qunqun Du, Xi Yao, Peng Zhang, Xiaonan Chen, Weiwei Xie, Zheng Li, Yuling Ma, Yan Zhu Wenxin Keli (WK), a Chinese patent medicine, is known to be effective for cardiac arrhythmias and heart failure. Although a number of electrophysiological findings regarding its therapeutic effects have been... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - March 25, 2017 Category: Molecular Biology Authors: Taiyi Wang Source Type: research
Predicting protein lysine phosphoglycerylation sites by hybridizing many sequence based features
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C6MB00875E, PaperQing-Yun Chen, Jijun Tang, Pufeng Du Post-translational modification (PTM) is essential for many biological processes. Covalent and generally enzymatic modification of proteins can impact the activity of proteins. Modified proteins would have more complex structures and... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - March 25, 2017 Category: Molecular Biology Authors: Qing-Yun Chen Source Type: research
A Systematic Reconstruction and Constraint-based Analysis of Leishmania donovani Metabolic Network: Identification of Potential Antileishmanial Drug Targets
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C6MB00823B, PaperMahesh Sharma, Naeem Shaikh, Shailendra Yadav, Sushma Singh, Prabha Garg Visceral leishmaniasis, a lethal parasitic disease, is caused by protozoan parasite Leishmania donovani. Absence of effective vaccine, drug toxicity and parasite resistance necessitates the identification of novel drug targets. Reconstruction... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - March 24, 2017 Category: Molecular Biology Authors: Mahesh Sharma Source Type: research
Stereoselective binding of agonists to the [small beta]2-adrenergic receptor: insights into molecular details and thermodynamics from molecular dynamics simulations
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C6MB00814C, PaperAnita Plazinska, Wojciech Plazinski The [small beta]2-adrenergic receptor ([small beta]2-AR) is one of the most studied G-protein-coupled receptors. When interacting with ligand molecule, it exhibits the binding characteristic that is strongly dependent on ligand stereoconfiguration. In... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - March 17, 2017 Category: Molecular Biology Authors: Anita Plazinska Source Type: research
Inhibition of MurA enzyme in Fusobacterium nucleatum by potential inhibitors identified through computational and in vitro approaches
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00074J, PaperAmit Kumar, Rajagopalan Saranathan , K. Prashanth , Basant K Tiwary, Krishna Ramadas Fusobacterium nucleatum plays a key role in several diseases such as periodontitis, gingivitis, appendicitis and inflammatory bowel disease (IBD). Development of antibiotic resistance by this bacterium demands for novel therapeutic... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - March 17, 2017 Category: Molecular Biology Authors: Amit Kumar Source Type: research
