Comprehensive analysis of long non-coding RNA-mRNA co-expression patterns in thyroid cancer
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00375G, PaperYaying Du, Wenfei Xia, Jinjun Zhang, Dongyi Wan, Zhifang Yang, Xingrui Li Novel molecular-targeted treatments show great prospect for radioiodine-refractory and surgically inoperable thyroid carcinomas. While aberrations in protein-coding genes are a focus in molecular thyroid cancer medicine, the impact of oncogenes... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - August 4, 2017 Category: Molecular Biology Authors: Yaying Du Source Type: research
Coarse-grained simulations of conformational changes in the multidrug efflux transporter AcrB
Mol. BioSyst., 2017, Advance Article DOI: 10.1039/C7MB00276A, PaperYead Jewel, Jin Liu, Prashanta Dutta Deprotonation of Asp408 in the transmembrane domain induces opening of the cleft and closing of the exit in the porter domain. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - August 3, 2017 Category: Molecular Biology Authors: Yead Jewel Source Type: research
A cross-platform metabolomics workflow for volume-restricted tissue samples: application to an animal model for polycystic kidney disease
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00245A, CommunicationElena Sanchez-Lopez, Hester Happe, Evelyne Steenvoorden, Antonio L Crego, maria luisa marina, Dorien Peters, Oleg A Mayboroda Metabolic profiling provides an unbiased view of the physiological status of an organism as a "function" of the metabolic composition of a measured sample. Here, we propose a simple LC-MS... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - August 2, 2017 Category: Molecular Biology Authors: Elena Sanchez-Lopez Source Type: research
Quantitative Investigation of MDA-MB-231 Breast Cancer Cell Motility: Dependence on Epidermal Growth Factor Concentration and Its Gradient
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00390K, PaperTanzila Islam, Haluk Resat Enhanced cell motility is one of the primary features of cancer. Accumulated evidence demonstrates that Epidermal Growth Factor Receptor (EGFR) mediated pathways play an important role in breast cancer cell... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - August 2, 2017 Category: Molecular Biology Authors: Tanzila Islam Source Type: research
MALDI MS imaging investigation of the host response to visceral leishmaniasis
Mol. BioSyst., 2017, Advance Article DOI: 10.1039/C7MB00306D, PaperC. F. Jaegger, F. Negrao, D. M. Assis, K. R. A. Belaz, C. F. F. Angolini, A. M. A. P. Fernandes, V. G. Santos, A. Pimentel, D. R. Abanades, S. Giorgio, M. N. Eberlin, D. F. O. Rocha MALDI MSI and statistical analysis revealed new features of the protein/peptide profile in mouse livers infected withLeishmania infantum at different stages of the disease. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - July 31, 2017 Category: Molecular Biology Authors: C. F. Jaegger Source Type: research
2,5-Hexanedione induces autophagic death of VSC4.1 cells via a PI3K/Akt/mTOR pathway
Mol. BioSyst., 2017, Advance Article DOI: 10.1039/C7MB00001D, PaperHuai Guan, Hua Piao, Zhiqiang Qian, Xueying Zhou, Yijie Sun, Chenxue Gao, Shuangyue Li, Fengyuan Piao 2,5-Hexanedione (HD) is an important bioactive metabolite ofn-hexane, which mediates the neurotoxicity of the parent compound. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - July 28, 2017 Category: Molecular Biology Authors: Huai Guan Source Type: research
Murine cutaneous leishmaniasis investigated by MALDI mass spectrometry imaging
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00411G, PaperFernanda Negrao, Daniele Fernanda de Olivera Rocha, Carol Jaegger Franco, Francisca Janaina Soares Rocha, Marcos N. Eberlin, Selma Giorgio Imaging mass spectrometry (IMS) is recognized as a powerful tool to investigate spacial distribution of untargeted or targeted molecules of a wide variety of samples including tissue sections. Leishmania is... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - July 27, 2017 Category: Molecular Biology Authors: Fernanda Negrao Source Type: research
Dissection of the Module Networks Implementation "LemonTree": Enhancements towards Applications in Metagenomics and Translation in Autoimmune Maladies
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00248C, PaperYoutao Lu, Xiaoyuan Zhou, Christine Nardini Under the current deluge of omics, module networks distinctively emerge as methods capable not only to identify inherently coherent groups (modules), thus reducing dimensionality, but also to hypothesize cause-effect relationships... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - July 26, 2017 Category: Molecular Biology Authors: Youtao Lu Source Type: research
Flexibility and electrostatic interactions on the coupled binding-folding mechanisms of Chz.core and H2A.z-H2B complex
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00103G, PaperXu Shang, Wen-Ting Chu, Xiakun Chu, Chuanbo Liu, Liufang Xu, Jin Wang The intrinsically disordered protein (IDP) Chz.core, which is the interaction core of Chz1, shows the binding preference to histone variant H2A.z. Although there are several studies on this protein binding,... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - July 25, 2017 Category: Molecular Biology Authors: Xu Shang Source Type: research
Restoring calcium homeostasis in diabetic cardiomyocytes: An investigation through mathematical modelling
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00264E, PaperPhonindra Das, Ajay Kumar, Nandadulal Bairagi, Samrat Chatterjee Calcium homeostasis is a key factor in regulation of cardiac excitation contraction coupling. Calcium dynamics in cardiomyocyte is governed by ATP which depends on insulin dependent glucose concentration, via Glucose... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - July 24, 2017 Category: Molecular Biology Authors: Phonindra Das Source Type: research
Protein stability and dynamics influenced by ligands in extremophilic complexes - a molecular dynamics investigation
In this study, we explore the structural and dynamic adaptations of theTryptophan synthase [small alpha]-subunit in a ligand bound state in psychrophilic, mesophilic and hyperthermophilic organisms at different temperatures by MD simulations. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - July 24, 2017 Category: Molecular Biology Authors: Sara Khan Source Type: research
A multiscale agent-based framework integrated with a constraint-based metabolic network model of cancer for simulating avascular tumor growth
Mol. BioSyst., 2017, Advance Article DOI: 10.1039/C7MB00050B, PaperMehrdad Ghadiri, Mahshid Heidari, Sayed-Amir Marashi, Seyed Hasan Mousavi The integration of an agent-based framework with a constraint-based metabolic network model of cancer for simulating avascular tumor growth. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - July 24, 2017 Category: Molecular Biology Authors: Mehrdad Ghadiri Source Type: research
Rational Design of an Orthogonal Noncovalent Interaction System at the MUPP1 PDZ11 Complex Interface with CaMKII[small alpha]-derived Peptides in Human Fertilization
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00379J, PaperYi-Le Zhang, Zhao-Feng Han The recognition and association between Ca2+/calmodulin-activated protein kinase II-[small alpha] (CaMKII[small alpha]) and multi-PDZ domain protein 1 (MUPP1) plays an important role in sperm acrosome reaction and human fertilization. Previously, we demonstrated... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - July 22, 2017 Category: Molecular Biology Authors: Yi-Le Zhang Source Type: research
Effect of ageing and Single Nucleotide Polymorphisms associated with risk of aggressive prostate cancer in a New Zealand population
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00203C, PaperVenkatesh Vaidyanathan, Vijay Naidu, Nishi Karunasinghe, Chi Hsiu-Juei Kao, Radha Pallati, Anower Jabed, Gareth Marlow, Prasanna Kallingappa, Lynette Ferguson Prostate cancer is one of the most significant male health concerns worldwide, various researchers carrying out molecular diagnostics have indicated that genetic interactions with biological and behavioral factors play an... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - July 22, 2017 Category: Molecular Biology Authors: Venkatesh Vaidyanathan Source Type: research
Effects of Threshold on the Topology of Gene Co-Expression Networks
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00101K, PaperCynthia Martins Villar Couto, Cesar Henrique Comin, Luciano da Fontoura Costa Several developments regarding the analysis of gene co-expression profiles using complex network theory have been reported recently. Such approaches usually start with the construction of an unweighted gene co-expression network,... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - July 22, 2017 Category: Molecular Biology Authors: Cynthia Martins Villar Couto Source Type: research
