Dynamic properties of dipeptidyl peptidase III from Bacteroides thetaiotaomicron and the structural basis for its substrate specificity - a computational study
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00310B, PaperMarko Tomin, Sanja Tomic Dipeptidyl peptidase III (DPP III) from the human gut symbiont Bacteroides thetaiotaomicron (Bt) is the first identified prokaryotic DPP III orthologue. It has low sequence similarity to the thoroughly studied... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - September 13, 2017 Category: Molecular Biology Authors: Marko Tomin Source Type: research
Enantioselective recognition of an isomeric ligand by a biomolecule: mechanistic insights into static and dynamic enantiomeric behavior and structural flexibility
Mol. BioSyst., 2017, Advance Article DOI: 10.1039/C7MB00378A, PaperWei Peng, Fei Ding Enantioselective biorecognition is a vital trigger that results in remarkable enantiomeric differences in the biochemical behavior of chiral substances. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - September 8, 2017 Category: Molecular Biology Authors: Wei Peng Source Type: research
Correction: An integrated anti-arrhythmic target network of compound Chinese medicine Wenxin Keli revealed by combined machine learning and molecular pathway analysis
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Taiyi Wang, Ming Lu, Qunqun Du, Xi Yao, Peng Zhang, Xiaonan Chen, Weiwei Xie, Zheng Li, Yuling Ma, Yan Zhu To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - September 8, 2017 Category: Molecular Biology Authors: Taiyi Wang Source Type: research
Computational study on the origin of the cancer immunotherapeutic potential of B and T cell epitope peptides
Mol. BioSyst., 2017, Advance Article DOI: 10.1039/C7MB00219J, PaperHao Li, Nalini Schaduangrat, Saw Simeon, Chanin Nantasenamat Computational analysis of anticancer humoral and cellular immunity activating dual response epitope peptides reveals significant differences to mono-response activating peptides. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - September 7, 2017 Category: Molecular Biology Authors: Hao Li Source Type: research
Methylglyoxal attenuates insulin signaling and downregulates the enzymes involved in cholesterol biosynthesis
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00305F, PaperArati Deshmukh, Shakuntala Bai, T Aarthy, Rubina S Kazi, Reema Banarjee, Rajeshwari Rathore, MV Vijayakumar , Hirekodathakallu V Thulasiram, Manoj Kumar Bhat, Mahesh J Kulkarni Methylglyoxal (MG) is a highly reactive dicarbonyl, known to be elevated in hyperglycemic condition of diabetes and is implicated in development of diabetic complications. Therefore, the current study investigates the... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - September 7, 2017 Category: Molecular Biology Authors: Arati Deshmukh Source Type: research
Hedgehog-mesenchyme gene signature identifies bi-modal prognosis in Luminal and Basal breast cancer sub-types
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00416H, PaperWandaliz Torres-Garcia, Maribella Domenech Hedgehog signaling (Hh) has been shown to be hyper-activated in several cancers. However, active Hh signaling can promote or inhibit tumor growth, thus identification of markers beyond main canonical Hh... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - September 7, 2017 Category: Molecular Biology Authors: Wandaliz Torres-Garcia Source Type: research
A novel method for identifying potential disease-related miRNAs via disease-miRNA-target heterogeneous network
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00485K, PaperLiang Ding, Minghui Wang, Dongdong Sun, Ao Li MicroRNAs (miRNAs), as a kind of important small endogenous single-stranded non-coding RNAs, play critical roles in a large number of human diseases. However, the currently known experimental verification of the... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - September 5, 2017 Category: Molecular Biology Authors: Liang Ding Source Type: research
Real-time activity assays of [small beta]-lactamases in living bacterial cells: application to the inhibition of antibiotic-resistant E. coli strains
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00487G, PaperYing Ge, Yajun Zhou, Ke-Wu Yang, Yilin Zhang, Yang Xiang, Yuejuan Zhang The emergence of antibiotic resistance caused by [small beta]-lactamases, including serine [small beta]-lactamases (S[small beta]Ls) and metallo-[small beta]-lactamases (M[small beta]Ls), is a global public health threat. L1, a B3 subclass M[small beta]L, hydrolyzes almost all of... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - September 4, 2017 Category: Molecular Biology Authors: Ying Ge Source Type: research
Investigation of a common gene expression signature in gastrointestinal cancers using systems biology approaches
Mol. BioSyst., 2017, Advance Article DOI: 10.1039/C7MB00450H, PaperKaveh Baghaei, Nazanin Hosseinkhan, Hamid Asadzadeh Aghdaei, M. R. Zali According to GLOBOCAN 2012, the incidence and the mortality rate of colorectal, stomach and liver cancers are the highest among the total gastrointestinal (GI) cancers. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - September 4, 2017 Category: Molecular Biology Authors: Kaveh Baghaei Source Type: research
CarSite: identify carbonylated sites of human proteins based on a one-sided selection resampling method
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00363C, PaperYun Zuo, Cangzhi Jia Protein carbonylation is one of the most important biomarkers of oxidative protein damage and such protein damage is linked to various diseases and aging. Therefore, it is vital that carbonylation... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - August 31, 2017 Category: Molecular Biology Authors: Yun Zuo Source Type: research
Long non-coding RNA SNHG17 is an unfavourable prognostic factor and promotes cell proliferation by epigenetically silencing P57 in colorectal cancer
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00280G, PaperZhonghua Ma, Shengying Gu, Min Song, Changsheng Yan, Bingqing Hui, Hao Ji, Jirong Wang, Jianping Zhang, Keming Wang, Qinghong Zhao Recently, substantial evidence has demonstrated that long non-coding RNAs (lncRNAs) play critical roles in multiple cancers including colorectal cancer (CRC). Utilizing publicly available lncRNA-expression-profiling data from the Gene Expression Omnibus... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - August 31, 2017 Category: Molecular Biology Authors: Zhonghua Ma Source Type: research
An immunoinformatics approach to promiscuous peptide design for the Plasmodium falciparum erythrocyte membrane protein-1
Mol. BioSyst., 2017, Advance Article DOI: 10.1039/C7MB00332C, PaperNazam Khan, Rajender Kumar, Shakti Chauhan, Umar Farooq Plasmodium falciparum erythrocyte membrane protein-1 (Pfemp-1), a variant adhesion molecule, can act as a key component of immunity against malaria. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - August 31, 2017 Category: Molecular Biology Authors: Nazam Khan Source Type: research
Mass spectrometry based identification of galectin-3 interacting proteins potentially involved in lung melanoma metastasis
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00260B, PaperManohar Dange, Hemangi Bhonsle, Rashmi K Godbole, Shyam More, Sanjay Bane, Mahesh J Kulkarni Adhesive interactions between molecules on tumor cells and those on target organ play a key role in organ specific metastasis. Poly-N-acetyl-lactosamine (polyLacNAc) substituted N-oligosaccharides on melanoma cell surface glycoproteins promote... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - August 25, 2017 Category: Molecular Biology Authors: Manohar Dange Source Type: research
Effects of flexibility and electrostatic interactions on the coupled binding-folding mechanisms of Chz.core and H2A.z-H2B
Mol. BioSyst., 2017, Advance Article DOI: 10.1039/C7MB00103G, PaperXu Shang, Wenting Chu, Xiakun Chu, Chuanbo Liu, Liufang Xu, Jin Wang The intrinsically disordered protein (IDP) Chz.core, which is the interaction core of Chz1, shows binding preference to histone variant H2A.z. The coupled folding-binding mechanism of the complex can be quantified by the free energy landscapes. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - August 23, 2017 Category: Molecular Biology Authors: Xu Shang Source Type: research
RNA-sequencing dissects the transcriptome of polyploid cancer cells that are resistant to combined treatments of cisplatin with paclitaxel and docetaxel
Mol. BioSyst., 2017, Advance Article DOI: 10.1039/C7MB00334J, PaperQianqian Wang, Fei Lu, Rongfeng Lan RNA-sequencing was performed to identify differentially expressed genes (DEGs) that may contribute to drug resistance in cancer cells treated with combined treatments of cisplatin with paclitaxel and docetaxel. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - August 21, 2017 Category: Molecular Biology Authors: Qianqian Wang Source Type: research
