CXCR7 attenuates the TGF-[small beta]-induced endothelial-to-mesenchymal transition and pulmonary fibrosis
Mol. BioSyst., 2017, Advance Article DOI: 10.1039/C7MB00247E, PaperShuhong Guan, Jun Zhou Lung fibrosis is a progressive and often fatal lung disease characterized by fibroblast proliferation and excessive deposition of extracellular matrix in the lungs. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - August 18, 2017 Category: Molecular Biology Authors: Shuhong Guan Source Type: research
Enantioselective recognition of isomeric ligand by biomolecule: Mechanistic insights from static, dynamic enantiomeric behavior and structural flexibility
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00378A, PaperWei Peng, Fei Ding Chirality is a ubiquitously basic attribute of nature, which relate inseparably to life activity of living organisms. However, enantiomeric difference has still failed to arouse enough attention during biological evaluation... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - August 18, 2017 Category: Molecular Biology Authors: Wei Peng Source Type: research
MicroRNAs Regulate the Main Events in Rice Drought Stress Response by Manipulating the Water Supply to Shoots
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00298J, PaperEhsan Mohseni Fard, Behnam Bakhshi, Mohammad Farsi, Amin Mirshamsi Kakhki, Nava Nikpay, Mohammad Ali Ebrahimi , Mohsen Mardi, Ghasem Hosseini Salekdeh MicroRNAs (miRNAs) are small endogenous regulatory RNAs that are involved in a variety of biological processes related to proliferation, development, and response to biotic and abiotic stresses. miRNA profiles of... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - August 17, 2017 Category: Molecular Biology Authors: Ehsan Mohseni Fard Source Type: research
Comprehensive analysis of long noncoding RNA-mRNA co-expression patterns in thyroid cancer
Mol. BioSyst., 2017, Advance Article DOI: 10.1039/C7MB00375G, PaperYaying Du, Wenfei Xia, Jinjun Zhang, Dongyi Wan, Zhifang Yang, Xingrui Li Novel molecular-targeted treatments show great prospects for radioiodine-refractory and surgically inoperable thyroid carcinomas. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - August 17, 2017 Category: Molecular Biology Authors: Yaying Du Source Type: research
mRNA-miRNA bipartite network reconstruction to predict prognostic module biomarkers in colorectal cancer stage differentiation
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00400A, PaperHabib Motieghader, Morteza Kouhsar, Ali Najafi, Balal Sadeghi , Ali Masoudi-Nejad Biomarker detection is one of the most important and challenging problems in cancer studies. Recently, non-coding RNA based biomarkers such as miRNAs expression level have been used for early diagnosis... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - August 16, 2017 Category: Molecular Biology Authors: Habib Motieghader Source Type: research
Dissection of the module network implementation "LemonTree": enhancements towards applications in metagenomics and translation in autoimmune maladies
Mol. BioSyst., 2017, Advance Article DOI: 10.1039/C7MB00248C, PaperYoutao Lu, Xiaoyuan Zhou, Christine Nardini Module networks model gene regulatory relationship and LemonTree is one of its popular implementations. This work reports a comprehensive performance characterization, proposes optimal parameter settings, patches the algorithm, and expands application to the human gut-intestinal metagenome for potential application in translational medicine. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - August 15, 2017 Category: Molecular Biology Authors: Youtao Lu Source Type: research
A systems biology approach to identify microRNAs contributing to cisplatin resistance in human ovarian cancer cells
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00362E, PaperWeisha Liu, Shuyuan Wang, Shunheng Zhou, Feng Yang, Wei Jiang, Qingyuan Zhang, Lihong Wang Cisplatin (CDDP)-based chemotherapy is a standard first-line therapy for ovarian cancer. However, drug resistance remains a major obstacle to its efficacy. Recently, increasing evidences suggested that the aberrant expression of... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - August 15, 2017 Category: Molecular Biology Authors: Weisha Liu Source Type: research
An immunoinformatics approach to promiscuous peptides design for Plasmodium falciparum erythrocyte membrane protein-1
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00332C, PaperNazam khan, Rajender kumar, Shakti Chauhan, Umar Farooq Plasmodium falciparum erythrocyte membrane protein-1 (Pfemp-1) a variant adhesion molecule can acts as key component of immunity against malaria. In the current scenario of malaria vaccines, no efficient vaccines are... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - August 12, 2017 Category: Molecular Biology Authors: Nazam khan Source Type: research
Discovering potential driver genes through an integrated model of somatic mutation profiles and gene functional information
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00303J, PaperJianing Xi, Minghui Wang, Ao Li The accumulating availability of next generation sequencing data offers an opportunity to pinpoint driver genes that are causally implicated in oncogenesis through computational models. Despite the previous efforts made on... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - August 12, 2017 Category: Molecular Biology Authors: Jianing Xi Source Type: research
Impact of Phenylalanines Outside the Dimer Interface on Phosphotriesterase Stability and Function
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00196G, PaperAndrew J Olsen, Leif A Halvorsen, Ching-Yao Yang, Roni Barak Ventura, Liming Yin, P Douglas Renfrew, Richard Bonneau, Jin Kim Montclare We explore the significance of phenylalanine outside of the phosphotriesterase (PTE) dimer interface through mutagenesis studies and computational modeling. Previous studies have demonstrated that the residue-specific incorporation of para-fluorophenylalanine (pFF)... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - August 10, 2017 Category: Molecular Biology Authors: Andrew J Olsen Source Type: research
CXCR7 attenuates TGF-[small beta]-induced endothelial-to-mesenchymal transition and pulmonary fibrosis
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00247E, PaperShuhong Guan, Jun Zhou Lung fibrosis is a progressive and often fatal lung disease characterized by fibroblast proliferation and excessive deposition of extracellular matrix in the lung. Chemokine receptor CXCR7 has been shown to... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - August 10, 2017 Category: Molecular Biology Authors: Shuhong Guan Source Type: research
Role of GARP in the activation of latent TGF-[small beta]1
Mol. BioSyst., 2017, Advance Article DOI: 10.1039/C7MB00251C, Review ArticleJulie Stockis, Olivier Dedobbeleer, Sophie Lucas GARP presents latent TGF-[small beta]1 on Tregs, and is indispensable for their active TGF-[small beta]1 production as shown with anti-GARP monoclonals. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - August 10, 2017 Category: Molecular Biology Authors: Julie Stockis Source Type: research
RNA-sequencing dissects the transcriptome of polyploid cancer cells that resistant to combined treatments of cisplatin with paclitaxel and docetaxel
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00334J, PaperQianqian Wang, Fei Lu, Rongfeng Lan Overcome chemoresistance will prevent cancer relapse and contribute to clinical chemotherapy. In order to explore the underlying mechanism of chemoresistance, we firstly incubated cancer cell with a combination of cisplatin+paclitaxel... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - August 8, 2017 Category: Molecular Biology Authors: Qianqian Wang Source Type: research
Effect of ageing and single nucleotide polymorphisms associated with the risk of aggressive prostate cancer in a New Zealand population
Mol. BioSyst., 2017, Advance Article DOI: 10.1039/C7MB00203C, PaperVenkatesh Vaidyanathan, Vijay Naidu, Nishi Karunasinghe, Chi Hsiu-Juei Kao, Radha Pallati, Anower Jabed, Gareth Marlow, Prasanna Kallingappa, Lynnette R. Ferguson Prostate cancer is one of the most significant male health concerns worldwide. Various researchers carrying out molecular diagnostics have indicated that genetic interactions with biological and behavioral factors play an important role in the overall risk and prognosis of this disease. These will be discussed in details with New Zealand perspective. To cite this article before page numbers are as...
Source: RSC - Molecular Biosystems - August 7, 2017 Category: Molecular Biology Authors: Venkatesh Vaidyanathan Source Type: research
Proximity aptasensor for protein detection based on an enzyme-free amplification strategy
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00458C, CommunicationDawei Yang, Yuguo Tang, Zhenzhen Guo, Xifeng Chen, Peng Miao A novel electrochemical aptasensor for detection of trace protein is proposed based on proximity binding-induced strand displacement and hybridization chain reaction. This method is proved to be highly selective and... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - August 4, 2017 Category: Molecular Biology Authors: Dawei Yang Source Type: research
