MicroRNA precursors identification using reduced and hybrid features
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00115K, PaperAsad Khan, Sajid Shah, Fazli Wahid, Fiaz Gul khan, Saima Jabeen The MicroRNAs (also called miRNAs) are a group of short non-coding RNA molecules. They have a vital role in a gene expression of transcriptional and post-transcriptional processes. However, the abnormality... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - June 15, 2017 Category: Molecular Biology Authors: Asad Khan Source Type: research
Fragile X mental retardation protein recognizes a G quadruplex structure within the survival motor neuron domain containing 1 mRNA 5[prime or minute]-UTR
Mol. BioSyst., 2017, Advance Article DOI: 10.1039/C7MB00070G, PaperDamian S. McAninch, Ashley M. Heinaman, Cara N. Lang, Kathryn R. Moss, Gary J. Bassell, Mihaela Rita Mihailescu, Timothy L. Evans SMNDC1 mRNA adopts a 5[prime or minute]-UTR G quadruplex structure recognized specifically by FMRP, potentially affecting spliceosome assembly in FXS. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - June 14, 2017 Category: Molecular Biology Authors: Damian S. McAninch Source Type: research
An integrative machine learning strategy for improved prediction of essential genes in Escherichia coli metabolism using flux-coupled features
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00234C, PaperSutanu Nandi, Abhishek Subramanian, RamRup Sarkar Prediction of essential genes helps to identify a minimal set of genes that are absolutely required for a cell for appropriate functioning and survival. Available machine learning techniques for essential... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - June 14, 2017 Category: Molecular Biology Authors: Sutanu Nandi Source Type: research
Predicting protein-protein interactions from protein sequences by a stacked sparse autoencoder deep neural network
Mol. BioSyst., 2017, Advance Article DOI: 10.1039/C7MB00188F, PaperYan-Bin Wang, Zhu-Hong You, Xiao Li, Tong-Hai Jiang, Xing Chen, Xi Zhou, Lei Wang Protein-protein interactions (PPIs) play an important role in most of the biological processes. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - June 12, 2017 Category: Molecular Biology Authors: Yan-Bin Wang Source Type: research
Unveiling a VEGF-mimetic peptide sequence in IQGAP1 protein
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00190H, PaperDomenica Capasso, Sonia Di Gaetano, Veronica Celentano, Donatella Diana, Luisa Festa, Rossella Di Stasi, Lucia De Rosa, Roberto Fattorusso, LUCA DOMENICO D'ANDREA The ability to modulate angiogenesis by chemical tools has several important applications in different scientific fields. In the perspective of finding novel proangiogenic molecules, we searched peptide sequences with a... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - June 12, 2017 Category: Molecular Biology Authors: Domenica Capasso Source Type: research
Dissecting binding of a [small beta] -barrel membrane protein by phage display
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00163K, PaperLuz Marina Meneghini, Sarvind Mani Tripathi, Marcus Woodworth, Sudipta Majumdar, Thomas Poulos, Gregory A Weiss Membrane proteins (MPs) constitute a third of all proteomes, and contribute to a myriad of cellular functions including intercellular communication, nutrient transport and energy generation. For example, TonB-dependent transporters (TBDTs)... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - June 12, 2017 Category: Molecular Biology Authors: Luz Marina Meneghini Source Type: research
Tetracycline-controllable artificial microRNA-HOTAIR+EZH2 suppressed the progression of bladder cancer cells
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00202E, PaperYincong Chen, Haibiao Xie, Yifan zou, Xiulan Lai, Lian Ma, Yuchen Liu, Jianfa Li Previous studies have suggested that EZH2 was up-regulated in bladder cancer tissues and identified as a biomarker for poor prognosis. However, the biological functions of EZH2 in bladder cancer cells... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - June 7, 2017 Category: Molecular Biology Authors: Yincong Chen Source Type: research
Proteomic analysis reveals Xuesaitong Injection attenuates myocardial ischemia/reperfusion injury by elevating pyruvate dehydrogenase-mediated aerobic metabolism
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00140A, PaperXiaoping Zhao, Feng Zhang, Yi Wang Xuesaitong Injection (XST), mainly consisted of Panax Notoginseng saponins, has been vigorously used for treating cardio-cerebral vascular diseases. However, the underlying mechanisms of XST associated with the cardioprotective effects are... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - June 7, 2017 Category: Molecular Biology Authors: Xiaoping Zhao Source Type: research
Literature-based prediction of novel drug indications considering relationships between entities
Mol. BioSyst., 2017, Advance Article DOI: 10.1039/C7MB00020K, PaperGiup Jang, Taekeon Lee, Byung Mun Lee, Youngmi Yoon There have been many attempts to identify and develop new uses for existing drugs, which is known as drug repositioning. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - June 5, 2017 Category: Molecular Biology Authors: Giup Jang Source Type: research
Ligand Induced Conformational Preorganization of Loops of c-MYC G-Quadruplex DNA and its Implications in Structure Specific Drug Design
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00175D, PaperHarikrishna S, Saikiran Kotaru, P. I. Pradeepkumar Stabilization of G-quadruplex (G4) DNA structure in the proto-oncogene c-MYC utilizing small molecule ligands has emerged as an attractive strategy to develop anticancer therapeutics. To understand the subtle structural changes... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - June 2, 2017 Category: Molecular Biology Authors: Harikrishna S Source Type: research
The effect of global transcriptional regulators on the anaerobic fermentative metabolism of Escherichia coli
Mol. BioSyst., 2017, Advance Article DOI: 10.1039/C6MB00721J, PaperManika Kargeti, K. V. Venkatesh The study describes the role of global transcription factors in efficiently balancing the redox and also in optimally channeling the carbon towards biomass. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - June 2, 2017 Category: Molecular Biology Authors: Manika Kargeti Source Type: research
What shapes eukaryotic transcriptional bursting?
Mol. BioSyst., 2017, Advance Article DOI: 10.1039/C7MB00154A, Review ArticleDamien Nicolas, Nick E. Phillips, Felix Naef In this review, we recapitulate how certain molecular aspects of transcription influence transcriptional bursting. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - June 2, 2017 Category: Molecular Biology Authors: Damien Nicolas Source Type: research
Modeling of alcohol oxidase enzyme of Candida boidinii and in silico analysis of competitive binding of proton ionophores and FAD with enzyme.
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00287D, PaperMohammad Wahab Khan, Ayaluru Murali Alcohol oxidase (AOX) is an important Flavin adenine dinucleotide (FAD) dependent oxidoreductase which is responsible for converting the methanol into formaldehyde and hydrogen peroxide for the growth of methylotrophic yeast... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - June 2, 2017 Category: Molecular Biology Authors: Mohammad Wahab Khan Source Type: research
Computational investigation on human SOD1 mutant (Cys146Arg) that directs familial amyotrophic lateral sclerosis
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00106A, PaperSrinivasan E, Rajasekaran R Genetic substitution mutation of Cys146Arg in SOD1 protein is predominantly found in the Japanese population suffering from familial amyotrophic lateral sclerosis (FALS). A complete study on the biophysical aspects of... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - June 2, 2017 Category: Molecular Biology Authors: Srinivasan E Source Type: research
Interaction and inhibitory influence of the azo dye carmoisine on lysozyme amyloid fibrillogenesis
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00207F, PaperAnirban Basu, Gopinatha Suresh Kumar The binding of the common food colorant carmoisine and its inhibitory effect on amyloid fibrillation in lysozyme have been investigated. Since humans are increasingly exposed to various food colorants like... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - June 1, 2017 Category: Molecular Biology Authors: Anirban Basu Source Type: research
