Decoding the regulatory mechanism of Glucose and Insulin induced Phosphatidylinositol 3,4,5-Trisphosphate dynamics in [small beta]-cells
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00227K, PaperTagari Samanta, Peeyush sharma, Dwijendra Prosad Kukri, Sandip Kar In MIN6 pancreatic [small beta]-cells, glucose and insulin act in a synergistic manner to regulate the dynamics of Phosphatidylinositol (3,4,5)-trisphosphate (PIP3). However, the precise regulatory mechanism behind such an experimentally observed... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - June 1, 2017 Category: Molecular Biology Authors: Tagari Samanta Source Type: research
Phosphorylation of Full Length Amyloid-[small beta] Peptide Modulates its Amyloid Aggregation, Cell Binding and Neurotoxic Properties
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00249A, PaperElahehsadat Jamasbi, Frances Separovic, Akhter Hossain, Giuseppe Donato Ciccotosto Amyloid beta peptide (A[small beta]) is the major protein component of the amyloid plaques that are present in brains of Alzheimer's disease (AD) patients. A[small beta]42 peptide is a known neurotoxic agent... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - June 1, 2017 Category: Molecular Biology Authors: Elahehsadat Jamasbi Source Type: research
Computational analysis of histidine mutations on the structure stability of human tyrosinases leading to albinism insurgence
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00211D, Papermubashir hassan, Qamar Abbas, Reza Hussain, Ahmed A Moustafa, Sung-Yum Seo Misfolding and structural alteration in proteins lead to serious malfunctions and cause various diseases in human. Mutations at the active binding site in tyrosinase impair structural stability and cause lethal... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - June 1, 2017 Category: Molecular Biology Authors: mubashir hassan Source Type: research
Mathematical modeling reveals differential regulation of MAPK activity by phosphatase proteins in the yeast pheromone response pathway
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00213K, PaperNathan Dyjack, Cassandra Azeredo Tseng, Necmettin Yildirim To prevent indefinite cellular response to external signals, cells utilize various adaptation mechanisms. The yeast mating-response pathway is a model cellular system that exhibits adaptation to persistent external signals. This... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - May 25, 2017 Category: Molecular Biology Authors: Nathan Dyjack Source Type: research
Identification of active components in Yixinshu Capsule with protective effects against myocardial dysfunction on human induced pluripotent stem cell-derived cardiomyocytes by an integrative approach
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C6MB00813E, PaperMinyu Zhang, Hongwei Wu, Feifei Guo, Yangyang Yu, Junying Wei, Ya Geng, Shifeng Wang, Shiyou Li, Hongjun Yang Traditional Chinese medicine (TCM) preparations have significant effects on some refractory diseases, while the compositions are complex and mechanisms are unknown. Identification of the active components in the preparations is... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - May 25, 2017 Category: Molecular Biology Authors: Minyu Zhang Source Type: research
Structure-based design of novel combinatorially generated NBTIs as potential DNA gyrase inhibitors against various Staphylococcus aureus mutant strains
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00168A, PaperAnja Kolaric, Nikola Minovski Although intercalating agents such as quinolones proved their therapeutic success as antibacterials for more than 40 years, the emergence of new forms of quinolone-caused resistance in bacteria is continually growing.... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - May 23, 2017 Category: Molecular Biology Authors: Anja Kolaric Source Type: research
Analysis of association of gene variants with obesity traits in New Zealand European children at 6 years of age.
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00104E, PaperMohanraj Krishnan, John Thompson, Edwin Mitchell, Rinki Murphy, Lesley McCowan, Andrew Shelling Childhood obesity is a public health problem, which is associated with a long-term increased risk of cardiovascular disease and premature mortality. Several gene variants have previously been identified that have... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - May 23, 2017 Category: Molecular Biology Authors: Mohanraj Krishnan Source Type: research
Literature-based prediction of novel drug indications considering relationship between entities
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00020K, PaperGiup Jang, Taekeon Lee, Byung Mun Lee, Youngmi Yoon There have been many attempts to identify and develop new uses for existing drugs, which is known as drug repositioning. Among these efforts, text mining is an effective means of... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - May 23, 2017 Category: Molecular Biology Authors: Giup Jang Source Type: research
vhfRNAi: A web-platform for analysis of host genes involved in viral infections discovered by genome wide RNAi screen
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C6MB00841K, PaperAnamika Thakur, Abid Qureshi, Manoj Kumar Knockdown of host genes using high-throughput genome-wide RNA interference screens have spotted numerous host factors that affect viral infections, which would be helpful in understanding host-virus interactions. We have developed... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - May 19, 2017 Category: Molecular Biology Authors: Anamika Thakur Source Type: research
Dynamic properties of the Growth Hormone Releasing Hormone Receptor (GHRHR) and molecular determinants of GHRH binding
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00130D, PaperMinos-Timotheos Matsoukas, Georgios A Spyroulias The growth hormone-releasing hormone receptor (GHRHR), is a member of the class B GPCR subfamily. GHRH, a 44-residue neuropeptide produced in the hypothalamus, regulates the secretion of growth hormone via... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - May 19, 2017 Category: Molecular Biology Authors: Minos-Timotheos Matsoukas Source Type: research
Effect of Global Transcriptional Regulators on anaerobic fermentative metabolism of Escherichia coli
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C6MB00721J, PaperManika Kargeti, Kareenhalli Viswanath Venkatesh Global transcription factors are known to regulate the anaerobic growth of Escherichia coli on glucose. These transcription factors help the organism to sense oxygen and accordingly regulate the synthesis of... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - May 19, 2017 Category: Molecular Biology Authors: Manika Kargeti Source Type: research
Correction: Metabolomic profiling and biochemical evaluation of the follicular fluid of endometriosis patients
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Marianna Santonastaso, Alessia Pucciarelli, Susan Costantini, Francesca Caprio, Angela Sorice, Francesca Capone, Antonella Natella, Patrizia Iardino, Nicola Colacurci, Emilio Chiosi To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - May 19, 2017 Category: Molecular Biology Authors: Marianna Santonastaso Source Type: research
System analysis identifies distinct and common functional networks governed by transcription factor ASCL1, in glioma and Small Cell Lung Cancer
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C6MB00851H, PaperSainitin Donakonda, Swati Sinha, Shrinivas Nivrutti Dighe, Satyanarayana M R Rao ASCL1 is a basic Helix-Loop-Helix transcription factor (TF), which is involved in various cellular processes like neuronal development and signaling pathways. Transcriptome profiling has shown that ASCL1 overexpression plays an... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - May 19, 2017 Category: Molecular Biology Authors: Sainitin Donakonda Source Type: research
Covalent inhibition of protein tyrosine phosphatases
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00151G, Review ArticleKasi Viswanatharaju Ruddraraju, Zhong-Yin Zhang Protein tyrosine phosphatases (PTPs) are a large family of 107 signaling enzymes that catalyze the hydrolytic removal of phosphate groups from tyrosine residues in a target protein. The phosphorylation status... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - May 17, 2017 Category: Molecular Biology Authors: Kasi Viswanatharaju Ruddraraju Source Type: research
Proteomic Analysis of Prognostic Plasma Biomarkers in Peripheral Arterial Occlusive Disease
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00229G, PaperCheng-San Yang, Yu-shan Wei, Han-Lin Tsai, Ian-Seng Cheong, Shing-Jyh Chang, Hsiu-Chuan Chou, Ying-Ray Lee, Hong-Lin Chan Peripheral arterial occlusive disease (PAOD), one of major manifestations of systemic atherosclerosis, causes intermittent claudication and rest pain. Patients with PAOD not only have reduced quality of life, but also... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - May 17, 2017 Category: Molecular Biology Authors: Cheng-San Yang Source Type: research
